TY - JOUR
T1 - MicroRNAs and atherosclerosis.
AU - Madrigal-Matute, Julio
AU - Rotllan, Noemi
AU - Aranda, Juan F.
AU - Fernández-Hernando, Carlos
N1 - Funding Information:
Acknowledgments This work was supported by Grants from the National Institutes of Health R01HL107953 and R01HL106063 (to C. Fernández-Hernando) and Ministerio de Educación [Programa Nacional de Movilidad de Recursos Humanos del Plan Nacional de I-D+i 2008–2011] (to N. R.). Figures were produced using Servier Medical Art (www.servier.com). We apologize to those whose work could not be cited owing to space limitations.
PY - 2013/5
Y1 - 2013/5
N2 - MicroRNAs (miRNAs) are small, ~22 nucleotide (nt) sequences of RNA that regulate gene expression at posttranscriptional level. These endogenous gene expression inhibitors were primarily described in cancer but recent exciting findings have also demonstrated a key role in cardiovascular diseases (CVDs), including atherosclerosis. MiRNAs control endothelial cell (EC), vascular smooth muscle cell (VSMC), and macrophage functions, and thereby regulate the progression of atherosclerosis. MiRNA expression is modulated by different stimuli involved in every stage of atherosclerosis, and conversely miRNAs modulates several pathways implicated in plaque development such as cholesterol metabolism. In the present review, we focus on the importance of miRNAs in atherosclerosis, and we further discuss their potential use as biomarkers and therapeutic targets in CVDs.
AB - MicroRNAs (miRNAs) are small, ~22 nucleotide (nt) sequences of RNA that regulate gene expression at posttranscriptional level. These endogenous gene expression inhibitors were primarily described in cancer but recent exciting findings have also demonstrated a key role in cardiovascular diseases (CVDs), including atherosclerosis. MiRNAs control endothelial cell (EC), vascular smooth muscle cell (VSMC), and macrophage functions, and thereby regulate the progression of atherosclerosis. MiRNA expression is modulated by different stimuli involved in every stage of atherosclerosis, and conversely miRNAs modulates several pathways implicated in plaque development such as cholesterol metabolism. In the present review, we focus on the importance of miRNAs in atherosclerosis, and we further discuss their potential use as biomarkers and therapeutic targets in CVDs.
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U2 - 10.1007/s11883-013-0322-z
DO - 10.1007/s11883-013-0322-z
M3 - Review article
C2 - 23512606
AN - SCOPUS:84883735147
VL - 15
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
SN - 0946-672X
IS - 5
M1 - 322
ER -
