MicroRNAs and atherosclerosis.

Julio Madrigal-Matute, Noemi Rotllan, Juan F. Aranda, Carlos Fernández-Hernando

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

MicroRNAs (miRNAs) are small, ~22 nucleotide (nt) sequences of RNA that regulate gene expression at posttranscriptional level. These endogenous gene expression inhibitors were primarily described in cancer but recent exciting findings have also demonstrated a key role in cardiovascular diseases (CVDs), including atherosclerosis. MiRNAs control endothelial cell (EC), vascular smooth muscle cell (VSMC), and macrophage functions, and thereby regulate the progression of atherosclerosis. MiRNA expression is modulated by different stimuli involved in every stage of atherosclerosis, and conversely miRNAs modulates several pathways implicated in plaque development such as cholesterol metabolism. In the present review, we focus on the importance of miRNAs in atherosclerosis, and we further discuss their potential use as biomarkers and therapeutic targets in CVDs.

Original languageEnglish (US)
Article number322
JournalUnknown Journal
Volume15
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Madrigal-Matute, J., Rotllan, N., Aranda, J. F., & Fernández-Hernando, C. (2013). MicroRNAs and atherosclerosis. Unknown Journal, 15(5), [322]. https://doi.org/10.1007/s11883-013-0322-z