microRNA regulation in megakaryocytopoiesis

Huiyuan Li, Haifeng Zhao, Donghai Wang, Renchi Yang

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Megakaryocytopoiesis is governed by a complex network of haematopoietic growth factors that regulate the different stages of the process, in which haematopoietic stem cells undergo megakaryocytic lineage commitment, proliferation, maturation, and functional activation to produce platelets. MicroRNAs (miRNA) are a class of about 22-nucleotide noncoding RNAs that have been highly conserved during evolution and play a significant role in haematopoiesis, including differentiation and lineage commitment of megakaryocyte. This review summarizes the miRNAs which have changed expression during megakaryocytopoiesis, and their positive and negative functions on megakaryocytic differentiation. In addition, the abnormal miRNA expression profiles in megakaryocytic disorders are reviewed.

Original languageEnglish (US)
Pages (from-to)298-307
Number of pages10
JournalBritish Journal of Haematology
Volume155
Issue number3
DOIs
StatePublished - Nov 1 2011

Keywords

  • Megakaryocytopoiesis
  • MicroRNA

ASJC Scopus subject areas

  • Hematology

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