MicroRNA and leukemia: Tiny molecule, great function

Haifeng Zhao, Donghai Wang, Weiting Du, Dongsheng Gu, Renchi Yang

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted messenger RNAs (mRNAs). It is known that aberrant microRNA expression can play a vital role in the pathology of leukemia, thus microRNAs have rapidly emerged as potential targets for therapeutics. This review focuses on recent researches on the important roles of microRNAs in the pathogenesis of leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL).

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Volume74
Issue number3
DOIs
StatePublished - Jun 1 2010

Keywords

  • Acute lymphoblastic leukemia
  • Acute myeloid leukemia
  • Chronic lymphocytic leukemia
  • Chronic myeloid leukemia
  • MicroRNA

ASJC Scopus subject areas

  • Hematology
  • Oncology

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