MicroRNA and leukemia: Tiny molecule, great function

Haifeng Zhao; Donghai Wang; Weiting Du; Dongsheng Gu; Renchi Yang

doi:10.1016/j.critrevonc.2009.05.001

MicroRNA and leukemia: Tiny molecule, great function

Haifeng Zhao, Donghai Wang, Weiting Du, Dongsheng Gu, Renchi Yang

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted messenger RNAs (mRNAs). It is known that aberrant microRNA expression can play a vital role in the pathology of leukemia, thus microRNAs have rapidly emerged as potential targets for therapeutics. This review focuses on recent researches on the important roles of microRNAs in the pathogenesis of leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL).

Original language	English (US)
Pages (from-to)	149-155
Number of pages	7
Journal	Critical Reviews in Oncology/Hematology
Volume	74
Issue number	3
DOIs	https://doi.org/10.1016/j.critrevonc.2009.05.001
State	Published - Jun 2010
Externally published	Yes

Keywords

Acute lymphoblastic leukemia
Acute myeloid leukemia
Chronic lymphocytic leukemia
Chronic myeloid leukemia
MicroRNA

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.critrevonc.2009.05.001

Cite this

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title = "MicroRNA and leukemia: Tiny molecule, great function",

abstract = "MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted messenger RNAs (mRNAs). It is known that aberrant microRNA expression can play a vital role in the pathology of leukemia, thus microRNAs have rapidly emerged as potential targets for therapeutics. This review focuses on recent researches on the important roles of microRNAs in the pathogenesis of leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL).",

keywords = "Acute lymphoblastic leukemia, Acute myeloid leukemia, Chronic lymphocytic leukemia, Chronic myeloid leukemia, MicroRNA",

author = "Haifeng Zhao and Donghai Wang and Weiting Du and Dongsheng Gu and Renchi Yang",

note = "Funding Information: This work was supported in part by grants of National Natural Science Foundation of China (30670900), Ministry of Education of China (20060023038), and Ministry of Health (200802031). ",

year = "2010",

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T1 - MicroRNA and leukemia

T2 - Tiny molecule, great function

AU - Zhao, Haifeng

AU - Wang, Donghai

AU - Du, Weiting

AU - Gu, Dongsheng

AU - Yang, Renchi

N1 - Funding Information: This work was supported in part by grants of National Natural Science Foundation of China (30670900), Ministry of Education of China (20060023038), and Ministry of Health (200802031).

PY - 2010/6

Y1 - 2010/6

N2 - MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted messenger RNAs (mRNAs). It is known that aberrant microRNA expression can play a vital role in the pathology of leukemia, thus microRNAs have rapidly emerged as potential targets for therapeutics. This review focuses on recent researches on the important roles of microRNAs in the pathogenesis of leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL).

AB - MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted messenger RNAs (mRNAs). It is known that aberrant microRNA expression can play a vital role in the pathology of leukemia, thus microRNAs have rapidly emerged as potential targets for therapeutics. This review focuses on recent researches on the important roles of microRNAs in the pathogenesis of leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL).

KW - Acute lymphoblastic leukemia

KW - Acute myeloid leukemia

KW - Chronic lymphocytic leukemia

KW - Chronic myeloid leukemia

KW - MicroRNA

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MicroRNA and leukemia: Tiny molecule, great function

Abstract

Keywords

ASJC Scopus subject areas

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