TY - JOUR
T1 - MicroPET/SPECT/CT imaging of small animal models of disease
AU - Koba, Wade
AU - Jelicks, Linda A.
AU - Fine, Eugene J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2013/2
Y1 - 2013/2
N2 - For the greater part of the last century, basic science research has been limited to in vitro studies of cellular processes and ex vivo tissue examination from suitable animal models of disease. In the last three decades, however, new techniques have been developed that permit the imaging of live animals using X-rays, radiotracer emissions, magnetic resonance signals, sound waves and optical fluorescence, and bioluminescence. The objective of this review is to provide a broad overview of common animal imaging modalities, with a focus on positron emission tomography (PET), single photon emission computed tomography (SPECT), and computed tomography (CT). Important examples, benefits, and limits of microPET/SPECT/CT technologies in current use, and their central role in improving our understanding of biological behavior and in facilitating the development of treatments from bench to bedside are included.
AB - For the greater part of the last century, basic science research has been limited to in vitro studies of cellular processes and ex vivo tissue examination from suitable animal models of disease. In the last three decades, however, new techniques have been developed that permit the imaging of live animals using X-rays, radiotracer emissions, magnetic resonance signals, sound waves and optical fluorescence, and bioluminescence. The objective of this review is to provide a broad overview of common animal imaging modalities, with a focus on positron emission tomography (PET), single photon emission computed tomography (SPECT), and computed tomography (CT). Important examples, benefits, and limits of microPET/SPECT/CT technologies in current use, and their central role in improving our understanding of biological behavior and in facilitating the development of treatments from bench to bedside are included.
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U2 - 10.1016/j.ajpath.2012.09.025
DO - 10.1016/j.ajpath.2012.09.025
M3 - Short survey
C2 - 23219729
AN - SCOPUS:84872733477
SN - 0002-9440
VL - 182
SP - 319
EP - 324
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 2
ER -