Microglial nodule encephalitis: Limited CNS infection despite disseminated systemic cryptococcosis

M. Edelman; M. C. Birkenhauer; J. J. Steinberg; D. W. Dickson; A. Casadevall; S. C. Lee

Microglial nodule encephalitis: Limited CNS infection despite disseminated systemic cryptococcosis

M. Edelman, M. C. Birkenhauer, J. J. Steinberg, D. W. Dickson, A. Casadevall, S. C. Lee

Research output: Contribution to journal › Article › peer-review

Abstract

A 28-year-old patient with AIDS was found at autopsy to have disseminated cryptococcal infection involving the lungs, spleen, lymph nodes, kidneys, gastrointestinal tract, thyroid, bone marrow, and liver. Despite widespread organ dissemination the patient did not have clinical or pathological evidence of meningitis. Microscopic examination of the brain showed cryptococci limited to the brainstem and basal ganglia; microglial nodules with multinucleate giant cells, a histological hallmark of HIV-1 encephalitis, were shown to contain Cryptococcus neoformans. This feature may suggest a form of synergism between HIV-1 and Cryptococcus neoformans. This case demonstrates an unusual form of cryptococcal neurotropism with limited CNS involvement.

Original language	English (US)
Pages (from-to)	30-33
Number of pages	4
Journal	Clinical Neuropathology
Volume	15
Issue number	1
State	Published - 1996
Externally published	Yes

Keywords

AIDS
Cryptococcus neoformans
HIV-1
Invasive mycosis
Meningitis
Polysaccharide

ASJC Scopus subject areas

Pathology and Forensic Medicine
Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Microglial nodule encephalitis: Limited CNS infection despite disseminated systemic cryptococcosis",

abstract = "A 28-year-old patient with AIDS was found at autopsy to have disseminated cryptococcal infection involving the lungs, spleen, lymph nodes, kidneys, gastrointestinal tract, thyroid, bone marrow, and liver. Despite widespread organ dissemination the patient did not have clinical or pathological evidence of meningitis. Microscopic examination of the brain showed cryptococci limited to the brainstem and basal ganglia; microglial nodules with multinucleate giant cells, a histological hallmark of HIV-1 encephalitis, were shown to contain Cryptococcus neoformans. This feature may suggest a form of synergism between HIV-1 and Cryptococcus neoformans. This case demonstrates an unusual form of cryptococcal neurotropism with limited CNS involvement.",

keywords = "AIDS, Cryptococcus neoformans, HIV-1, Invasive mycosis, Meningitis, Polysaccharide",

author = "M. Edelman and Birkenhauer, {M. C.} and Steinberg, {J. J.} and Dickson, {D. W.} and A. Casadevall and Lee, {S. C.}",

year = "1996",

language = "English (US)",

volume = "15",

pages = "30--33",

journal = "Clinical Neuropathology",

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TY - JOUR

T1 - Microglial nodule encephalitis

T2 - Limited CNS infection despite disseminated systemic cryptococcosis

AU - Edelman, M.

AU - Birkenhauer, M. C.

AU - Steinberg, J. J.

AU - Dickson, D. W.

AU - Casadevall, A.

AU - Lee, S. C.

PY - 1996

Y1 - 1996

N2 - A 28-year-old patient with AIDS was found at autopsy to have disseminated cryptococcal infection involving the lungs, spleen, lymph nodes, kidneys, gastrointestinal tract, thyroid, bone marrow, and liver. Despite widespread organ dissemination the patient did not have clinical or pathological evidence of meningitis. Microscopic examination of the brain showed cryptococci limited to the brainstem and basal ganglia; microglial nodules with multinucleate giant cells, a histological hallmark of HIV-1 encephalitis, were shown to contain Cryptococcus neoformans. This feature may suggest a form of synergism between HIV-1 and Cryptococcus neoformans. This case demonstrates an unusual form of cryptococcal neurotropism with limited CNS involvement.

AB - A 28-year-old patient with AIDS was found at autopsy to have disseminated cryptococcal infection involving the lungs, spleen, lymph nodes, kidneys, gastrointestinal tract, thyroid, bone marrow, and liver. Despite widespread organ dissemination the patient did not have clinical or pathological evidence of meningitis. Microscopic examination of the brain showed cryptococci limited to the brainstem and basal ganglia; microglial nodules with multinucleate giant cells, a histological hallmark of HIV-1 encephalitis, were shown to contain Cryptococcus neoformans. This feature may suggest a form of synergism between HIV-1 and Cryptococcus neoformans. This case demonstrates an unusual form of cryptococcal neurotropism with limited CNS involvement.

KW - AIDS

KW - Cryptococcus neoformans

KW - HIV-1

KW - Invasive mycosis

KW - Meningitis

KW - Polysaccharide

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M3 - Article

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AN - SCOPUS:0030049858

SN - 0722-5091

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Microglial nodule encephalitis: Limited CNS infection despite disseminated systemic cryptococcosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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