Microbial transformation of widely used pharmaceutical and personal care product compounds

Abigail W. Porter; Sarah J. Wolfson; Max Häggblom; Lily Y. Youn

doi:10.12688/f1000research.21827.1

Microbial transformation of widely used pharmaceutical and personal care product compounds

Abigail W. Porter, Sarah J. Wolfson, Max Häggblom, Lily Y. Youn

Systems & Computational Biology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.:.

Original language	English (US)
Article number	130
Journal	F1000Research
Volume	9
DOIs	https://doi.org/10.12688/f1000research.21827.1
State	Published - 2020

Keywords

Anaerobic O-demethylation
Anaerobic o-methylation
Biotransformation
Pharmaceutical biodegradation

ASJC Scopus subject areas

General Immunology and Microbiology
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.12688/f1000research.21827.1

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title = "Microbial transformation of widely used pharmaceutical and personal care product compounds",

abstract = "Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.:.",

keywords = "Anaerobic O-demethylation, Anaerobic o-methylation, Biotransformation, Pharmaceutical biodegradation",

author = "Porter, {Abigail W.} and Wolfson, {Sarah J.} and Max H{\"a}ggblom and Youn, {Lily Y.}",

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year = "2020",

doi = "10.12688/f1000research.21827.1",

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journal = "F1000Research",

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T1 - Microbial transformation of widely used pharmaceutical and personal care product compounds

AU - Porter, Abigail W.

AU - Wolfson, Sarah J.

AU - Häggblom, Max

AU - Youn, Lily Y.

PY - 2020

Y1 - 2020

N2 - Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.:.

AB - Pharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation.:.

KW - Anaerobic O-demethylation

KW - Anaerobic o-methylation

KW - Biotransformation

KW - Pharmaceutical biodegradation

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M3 - Review article

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SN - 2046-1402

VL - 9

JO - F1000Research

JF - F1000Research

M1 - 130

ER -

Microbial transformation of widely used pharmaceutical and personal care product compounds

Abstract

Keywords

ASJC Scopus subject areas

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