Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beams' array interlacing

F. Avraham Dilmanian, Pantaleo Romanelli, Zhong Zhong, Ruiliang Wang, Mark E. Wagshul, John Kalef-Ezra, Marek J. Maryanski, Eliot M. Rosen, David J. Anschel

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The tissue-sparing effect of parallel, thin (narrower than 100 μm) synchrotron-generated X-ray planar beams (microbeams) in healthy tissues including the central nervous system (CNS) is known since early 1990s. This, together with a remarkable preferential tumoricidal effect of such beam arrays observed at high doses, has been the basis for labeling the method microbeam radiation therapy (MRT). Recent studies showed that beams as thick as 0.68 mm ("thick microbeams") retain part of their sparing effect in the rat's CNS, and that two such orthogonal microbeams arrays can be interlaced to produce an unsegmented field at the target, thus producing focal targeting. We measured the half-value layer (HVL) of our 120-keV median-energy beam in water phantoms, and we irradiated stereotactically bis acrylamide nitrogen gelatin (BANG)-gel-filled phantoms, including one containing a human skull, with interlaced microbeams and imaged them with MRI. A 43-mm water HVL resulted, together with an adequately large peak-to-valley ratio of the microbeams' three-dimensional dose distribution in the vicinity of the 20 mm × 20 mm × 20 mm target deep into the skull. Furthermore, the 80-20% dose falloff was a fraction of a millimeter as predicted by Monte Carlo simulations. We conclude that clinical MRT will benefit from the use of higher beam energies than those used here, although the current energy could serve certain neurosurgical applications. Furthermore, thick microbeams particularly when interlaced present some advantages over thin microbeams in that they allow the use of higher beam energies and they could conceivably be implemented with high power orthovoltage X-ray tubes.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalEuropean Journal of Radiology
Volume68
Issue number3 SUPPL.
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

Acrylamide
Gelatin
Skull
Nitrogen
Radiotherapy
Central Nervous System
Gels
X-Rays
Synchrotrons
Water

Keywords

  • Brain
  • Microbeam
  • Microradiosurgery
  • Radiation therapy
  • Radiosurgery
  • Synchrotron X-rays

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Microbeam radiation therapy : Tissue dose penetration and BANG-gel dosimetry of thick-beams' array interlacing. / Dilmanian, F. Avraham; Romanelli, Pantaleo; Zhong, Zhong; Wang, Ruiliang; Wagshul, Mark E.; Kalef-Ezra, John; Maryanski, Marek J.; Rosen, Eliot M.; Anschel, David J.

In: European Journal of Radiology, Vol. 68, No. 3 SUPPL., 12.2008, p. 129-136.

Research output: Contribution to journalArticle

Dilmanian, FA, Romanelli, P, Zhong, Z, Wang, R, Wagshul, ME, Kalef-Ezra, J, Maryanski, MJ, Rosen, EM & Anschel, DJ 2008, 'Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beams' array interlacing', European Journal of Radiology, vol. 68, no. 3 SUPPL., pp. 129-136. https://doi.org/10.1016/j.ejrad.2008.04.055
Dilmanian, F. Avraham ; Romanelli, Pantaleo ; Zhong, Zhong ; Wang, Ruiliang ; Wagshul, Mark E. ; Kalef-Ezra, John ; Maryanski, Marek J. ; Rosen, Eliot M. ; Anschel, David J. / Microbeam radiation therapy : Tissue dose penetration and BANG-gel dosimetry of thick-beams' array interlacing. In: European Journal of Radiology. 2008 ; Vol. 68, No. 3 SUPPL. pp. 129-136.
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