Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection

Christina M. Wyatt, Donald R. Hoover, Qiuhu Shi, Eric Seaberg, Catherine Wei, Phyllis C. Tien, Roksana Karim, Jason Lazar, Mary A. Young, Mardge H. Cohen, Paul E. Klotman, Kathryn Anastos

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Objectives: Prevalence of microalbuminuria is increased in patients with HIV. Microalbuminuria is associated with increased mortality in other populations, including diabetics, for whom microalbuminuria testing is standard of care. We investigated whether microalbuminuria is associated with mortality in HIV-infected women not receiving antiretroviral therapy. Methods: Urinalysis for proteinuria and semiquantitative testing for microalbuminuria were performed in specimens from 2 consecutive visits in 1547 HIV-infected women enrolled in the Women's Interagency HIV Study in 1994-1995. Time to death was modeled using proportional hazards analysis. Results: Compared with women without albuminuria, the hazard ratio (HR) for all-cause mortality was increased in women with 1 (HR: 3.4; 95% CI: 2.2 to 5.2) or 2 specimens positive for either proteinuria or microalbuminuria (HR: 3.9; 95% CI: 2.1 to 7.0). The highest risk was observed in women with both specimens positive for proteinuria (HR: 5.8; 95% CI: 3.4 to 9.8). The association between albuminuria and all-cause mortality risk remained significant after adjustment for demographics, HIV disease severity, and related comorbidities. Similar results were obtained for AIDS death. Conclusions: We identified a graded relationship between albuminuria and the risk of all-cause and AIDS mortality.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume55
Issue number1
DOIs
StatePublished - Sep 1 2010

Keywords

  • HIV
  • Microalbuminuria
  • Mortality
  • Proteinuria

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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