Abstract
Reports from the past couple of years point to an emerging association of the biogenesis, composition and ultrastructural morphology of MHC class II compartments (MIICs) with their functions in antigen processing and loading. Growth factors and cytokines involved in dendritic cell maturation have been shown to regulate MIIC biogenesis, and the MHC-class-II-associated invariant chain chaperone has been reported to regulate endosomal morphology and vacuolation. Differences among ultrastructurally distinct MIICs have begun to be appreciated with regard to variation in antigen loading capacity and to polarization of MHC class II conformational variants among different compartments. Finally, the MIIC ultrastructure organizes the mechanism of MHC class II surface trafficking. Together, these findings begin to shed light on the connection between MIIC protein content, MIIC morphology and MHC class II-related antigen processing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 64-69 |
| Number of pages | 6 |
| Journal | Current Opinion in Immunology |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2006 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
MHC class II compartment subtypes : Structure and function. / Stern, Lawrence J.; Potolicchio, Ilaria; Santambrogio, Laura.
In: Current Opinion in Immunology, Vol. 18, No. 1, 02.2006, p. 64-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MHC class II compartment subtypes
T2 - Structure and function
AU - Stern, Lawrence J.
AU - Potolicchio, Ilaria
AU - Santambrogio, Laura
PY - 2006/2
Y1 - 2006/2
N2 - Reports from the past couple of years point to an emerging association of the biogenesis, composition and ultrastructural morphology of MHC class II compartments (MIICs) with their functions in antigen processing and loading. Growth factors and cytokines involved in dendritic cell maturation have been shown to regulate MIIC biogenesis, and the MHC-class-II-associated invariant chain chaperone has been reported to regulate endosomal morphology and vacuolation. Differences among ultrastructurally distinct MIICs have begun to be appreciated with regard to variation in antigen loading capacity and to polarization of MHC class II conformational variants among different compartments. Finally, the MIIC ultrastructure organizes the mechanism of MHC class II surface trafficking. Together, these findings begin to shed light on the connection between MIIC protein content, MIIC morphology and MHC class II-related antigen processing.
AB - Reports from the past couple of years point to an emerging association of the biogenesis, composition and ultrastructural morphology of MHC class II compartments (MIICs) with their functions in antigen processing and loading. Growth factors and cytokines involved in dendritic cell maturation have been shown to regulate MIIC biogenesis, and the MHC-class-II-associated invariant chain chaperone has been reported to regulate endosomal morphology and vacuolation. Differences among ultrastructurally distinct MIICs have begun to be appreciated with regard to variation in antigen loading capacity and to polarization of MHC class II conformational variants among different compartments. Finally, the MIIC ultrastructure organizes the mechanism of MHC class II surface trafficking. Together, these findings begin to shed light on the connection between MIIC protein content, MIIC morphology and MHC class II-related antigen processing.
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UR - http://www.scopus.com/inward/citedby.url?scp=30044439442&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2005.11.005
DO - 10.1016/j.coi.2005.11.005
M3 - Article
C2 - 16337363
AN - SCOPUS:30044439442
VL - 18
SP - 64
EP - 69
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 1
ER -