MHC class II compartment subtypes: Structure and function

Lawrence J. Stern, Ilaria Potolicchio, Laura Santambrogio

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

Reports from the past couple of years point to an emerging association of the biogenesis, composition and ultrastructural morphology of MHC class II compartments (MIICs) with their functions in antigen processing and loading. Growth factors and cytokines involved in dendritic cell maturation have been shown to regulate MIIC biogenesis, and the MHC-class-II-associated invariant chain chaperone has been reported to regulate endosomal morphology and vacuolation. Differences among ultrastructurally distinct MIICs have begun to be appreciated with regard to variation in antigen loading capacity and to polarization of MHC class II conformational variants among different compartments. Finally, the MIIC ultrastructure organizes the mechanism of MHC class II surface trafficking. Together, these findings begin to shed light on the connection between MIIC protein content, MIIC morphology and MHC class II-related antigen processing.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalCurrent Opinion in Immunology
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 1 2006

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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