Methylxanthines and benign proliferative epithelial disorders of the breast in women

Thomas E. Rohan, M. G. Cook, A. J. Mcmichael

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Rohan T E (CSIRO Division of Human Nutrition, Kintore Avenue, Adelaide, South Australia 5000), Cook M G and McMichael A J. Methylxathines and benign proliferative epithelial disorders of the breast in women. International Journal of Epidemiology 1989, 18: 626-633.The relationship between methylxanthine intake (caffeine, theobromine and theophylline) and risk of benign proliferative epithelial disorders (BPED) of the breast was examined in a case-control study conducted in Adelaide, South Australia. The study involved 383 cases with biopsy-confirmed BPED, 192 controls whose biopsy did not show epithelial proliferation, and 383 unbiopsied community controls individually matched to cases on age and area of residence. Overall, there was relatively little variation in risk of BPED with total methylxanthine intake, or with intake of caffeine or theophylline, while there was a positive association between theobromine intake and risk of BPED, but only when cases were compared with biopsy controls. Total methylxanthine intake was positively associated with risk of BPED showing severe atypia, but the trend in risk was statistically significant only when community controls formed the comparison group. These data do not provide strong support for an association between methylxanthine intake and risk of BPED.

Original languageEnglish (US)
Pages (from-to)626-633
Number of pages8
JournalInternational Journal of Epidemiology
Volume18
Issue number3
DOIs
StatePublished - Sep 1989
Externally publishedYes

Fingerprint

Disorder
Breast
Biopsy
Theobromine
Caffeine
South Australia
Theophylline
Epidemiology
Nutrition
Case-control Study
methylxanthine
Case-Control Studies
Proliferation
Division

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Epidemiology

Cite this

Methylxanthines and benign proliferative epithelial disorders of the breast in women. / Rohan, Thomas E.; Cook, M. G.; Mcmichael, A. J.

In: International Journal of Epidemiology, Vol. 18, No. 3, 09.1989, p. 626-633.

Research output: Contribution to journalArticle

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