Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury study

M. B. Bracken, M. J. Shepard, K. G. Hellenbrand, W. F. Collins, L. S. Leo, D. F. Freeman, F. C. Wagner, Eugene S. Flamm, H. M. Eisenberg, J. H. Goodman

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

A multi-center double-blind randomized clinical trial was conducted by the National Acute Spinal Cord Injury Study Group to examine the efficacy of high-dose methylprednisolone (1000-mg blous and 1000 mg daily thereafter for 10 days) compared with that of a standard dose (100-mg bolus and 100 mg daily for 10 days). No significant difference was observed in neurological recovery of motor function, pinprick response, or touch sensation 1 year after injury between the two treatment groups, after adjustment for other potentially confounding factors. Analyses that specifically took into account the patients' total steroid dose and relative weight confirmed the lack of a steroid treatment effect. The case fatality rate was 10.7% during the 1st year after injury, and this was not associated with the steroid treatment protocol or the patient's gender. Deaths did occur significantly more frequently among patients who were completely (15.3%) and partially (8.6%) plegic than among those who were paretic (2.5%, p=0.0005), and among patients aged 50 years or older (38.6%, p=0.0001).

Original languageEnglish (US)
Pages (from-to)704-713
Number of pages10
JournalJournal of Neurosurgery
Volume63
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

Methylprednisolone
Spinal Cord Injuries
Steroids
Recovery of Function
Wounds and Injuries
Touch
Clinical Protocols
Randomized Controlled Trials
Weights and Measures
Mortality
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Bracken, M. B., Shepard, M. J., Hellenbrand, K. G., Collins, W. F., Leo, L. S., Freeman, D. F., ... Goodman, J. H. (1985). Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury study. Journal of Neurosurgery, 63(5), 704-713.

Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury study. / Bracken, M. B.; Shepard, M. J.; Hellenbrand, K. G.; Collins, W. F.; Leo, L. S.; Freeman, D. F.; Wagner, F. C.; Flamm, Eugene S.; Eisenberg, H. M.; Goodman, J. H.

In: Journal of Neurosurgery, Vol. 63, No. 5, 1985, p. 704-713.

Research output: Contribution to journalArticle

Bracken, MB, Shepard, MJ, Hellenbrand, KG, Collins, WF, Leo, LS, Freeman, DF, Wagner, FC, Flamm, ES, Eisenberg, HM & Goodman, JH 1985, 'Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury study', Journal of Neurosurgery, vol. 63, no. 5, pp. 704-713.
Bracken, M. B. ; Shepard, M. J. ; Hellenbrand, K. G. ; Collins, W. F. ; Leo, L. S. ; Freeman, D. F. ; Wagner, F. C. ; Flamm, Eugene S. ; Eisenberg, H. M. ; Goodman, J. H. / Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury study. In: Journal of Neurosurgery. 1985 ; Vol. 63, No. 5. pp. 704-713.
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