Methylphenidate analogs with behavioral differences interact differently with arginine residues on the dopamine transporter in rat striatum

Trent J. Volz, Nicole L. Bjorklund, James O. Schenk

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The methylphenidate analogs N-methyl-4-methyl-methylphenidate and N-benzylmethylphenidate are believed to interact differently with the dopamine transporter (DAT) in vitro and in vivo. Herein, we report that methylphenidate and N-methyl-4-methyl-methylphenidate, but not N-benzylmethylphenidate, protect the rat striatal DAT from the arginine-selective chemical modifying agent, phenylglyoxal. This suggests that methylphenidate and N-methyl-4-methyl- methylphenidate, but not N-benzylmethylphenidate, interact with the guanidine groups of arginine residues in the DAT of rat striatum. This differential interaction may, at least in part, explain the in vitro and in vivo differences between N-methyl-4-methyl-methylphenidate and N-benzylmethylphenidate.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalSynapse
Volume57
Issue number3
DOIs
StatePublished - Sep 1 2005

Keywords

  • Binding site
  • Phenylglyoxal
  • Rotating disk electrode voltammetry

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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