Methylmercury neurotoxicity: Why are some cells more vulnerable than others?

Parvinder Kaur, Michael Aschner, Tore Syversen

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Methylmercury (MeHg) is a ubiquitous environmental contaminant which produces well-defined neuropathologic alterations in the central nervous system. The cerebellum and visual cortex are the two primary targets of MeHg-induced neurotoxicity in both humans and mammals, and these targets are also reflected in the clinical symptoms. In the cerebellum, granule cells are extremely sensitive to MeHg-induced neurotoxicity, whereas neighboring Purkinje cells are spared, although they accumulate as much or more MeHg as compared to the cerebellar granule cells. The current review discusses several innate characteristics of each of these two cell types which may contribute to the differential selectivity of MeHg.

Original languageEnglish (US)
Title of host publicationMethylmercury and Neurotoxicity
PublisherSpringer US
Pages241-258
Number of pages18
ISBN (Electronic)9781461423836
ISBN (Print)9781461423829
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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    Kaur, P., Aschner, M., & Syversen, T. (2012). Methylmercury neurotoxicity: Why are some cells more vulnerable than others? In Methylmercury and Neurotoxicity (pp. 241-258). Springer US. https://doi.org/10.1007/978-1-4614-2383-6_13