Methylmercury neurotoxicity: Why are some cells more vulnerable than others?

Parvinder Kaur, Michael Aschner, Tore Syversen

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Methylmercury (MeHg) is a ubiquitous environmental contaminant which produces well-defined neuropathologic alterations in the central nervous system. The cerebellum and visual cortex are the two primary targets of MeHg-induced neurotoxicity in both humans and mammals, and these targets are also reflected in the clinical symptoms. In the cerebellum, granule cells are extremely sensitive to MeHg-induced neurotoxicity, whereas neighboring Purkinje cells are spared, although they accumulate as much or more MeHg as compared to the cerebellar granule cells. The current review discusses several innate characteristics of each of these two cell types which may contribute to the differential selectivity of MeHg.

Original languageEnglish (US)
Title of host publicationMethylmercury and Neurotoxicity
PublisherSpringer US
Pages241-258
Number of pages18
ISBN (Electronic)9781461423836
ISBN (Print)9781461423829
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Cerebellum
Purkinje Cells
Visual Cortex
Mammals
Central Nervous System

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Kaur, P., Aschner, M., & Syversen, T. (2012). Methylmercury neurotoxicity: Why are some cells more vulnerable than others? In Methylmercury and Neurotoxicity (pp. 241-258). Springer US. https://doi.org/10.1007/978-1-4614-2383-6_13

Methylmercury neurotoxicity : Why are some cells more vulnerable than others? / Kaur, Parvinder; Aschner, Michael; Syversen, Tore.

Methylmercury and Neurotoxicity. Springer US, 2012. p. 241-258.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kaur, P, Aschner, M & Syversen, T 2012, Methylmercury neurotoxicity: Why are some cells more vulnerable than others? in Methylmercury and Neurotoxicity. Springer US, pp. 241-258. https://doi.org/10.1007/978-1-4614-2383-6_13
Kaur, Parvinder ; Aschner, Michael ; Syversen, Tore. / Methylmercury neurotoxicity : Why are some cells more vulnerable than others?. Methylmercury and Neurotoxicity. Springer US, 2012. pp. 241-258
@inbook{7beca41e2c6e45a48341d3a82ab84794,
title = "Methylmercury neurotoxicity: Why are some cells more vulnerable than others?",
abstract = "Methylmercury (MeHg) is a ubiquitous environmental contaminant which produces well-defined neuropathologic alterations in the central nervous system. The cerebellum and visual cortex are the two primary targets of MeHg-induced neurotoxicity in both humans and mammals, and these targets are also reflected in the clinical symptoms. In the cerebellum, granule cells are extremely sensitive to MeHg-induced neurotoxicity, whereas neighboring Purkinje cells are spared, although they accumulate as much or more MeHg as compared to the cerebellar granule cells. The current review discusses several innate characteristics of each of these two cell types which may contribute to the differential selectivity of MeHg.",
author = "Parvinder Kaur and Michael Aschner and Tore Syversen",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/978-1-4614-2383-6_13",
language = "English (US)",
isbn = "9781461423829",
pages = "241--258",
booktitle = "Methylmercury and Neurotoxicity",
publisher = "Springer US",

}

TY - CHAP

T1 - Methylmercury neurotoxicity

T2 - Why are some cells more vulnerable than others?

AU - Kaur, Parvinder

AU - Aschner, Michael

AU - Syversen, Tore

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Methylmercury (MeHg) is a ubiquitous environmental contaminant which produces well-defined neuropathologic alterations in the central nervous system. The cerebellum and visual cortex are the two primary targets of MeHg-induced neurotoxicity in both humans and mammals, and these targets are also reflected in the clinical symptoms. In the cerebellum, granule cells are extremely sensitive to MeHg-induced neurotoxicity, whereas neighboring Purkinje cells are spared, although they accumulate as much or more MeHg as compared to the cerebellar granule cells. The current review discusses several innate characteristics of each of these two cell types which may contribute to the differential selectivity of MeHg.

AB - Methylmercury (MeHg) is a ubiquitous environmental contaminant which produces well-defined neuropathologic alterations in the central nervous system. The cerebellum and visual cortex are the two primary targets of MeHg-induced neurotoxicity in both humans and mammals, and these targets are also reflected in the clinical symptoms. In the cerebellum, granule cells are extremely sensitive to MeHg-induced neurotoxicity, whereas neighboring Purkinje cells are spared, although they accumulate as much or more MeHg as compared to the cerebellar granule cells. The current review discusses several innate characteristics of each of these two cell types which may contribute to the differential selectivity of MeHg.

UR - http://www.scopus.com/inward/record.url?scp=84922290719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922290719&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-2383-6_13

DO - 10.1007/978-1-4614-2383-6_13

M3 - Chapter

AN - SCOPUS:84922290719

SN - 9781461423829

SP - 241

EP - 258

BT - Methylmercury and Neurotoxicity

PB - Springer US

ER -