Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

P. E. Slagboom; A. G. Uitterlinden; J. Vijg

doi:10.1007/BF03323991

Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

P. E. Slagboom, A. G. Uitterlinden, J. Vijg

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)

Original language	English (US)
Pages (from-to)	141-146
Number of pages	6
Journal	Aging Clinical and Experimental Research
Volume	3
Issue number	2
DOIs	https://doi.org/10.1007/BF03323991
State	Published - Jun 1991
Externally published	Yes

Keywords

Aging
DNA methylation
MHC
cKi-ras
pituitary gland tumor

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF03323991

Cite this

@article{8094f62c300c4df99dcb0831ef9704be,

title = "Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis",

abstract = "Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)",

keywords = "Aging, DNA methylation, MHC, cKi-ras, pituitary gland tumor",

author = "Slagboom, {P. E.} and Uitterlinden, {A. G.} and J. Vijg",

year = "1991",

month = jun,

doi = "10.1007/BF03323991",

language = "English (US)",

volume = "3",

pages = "141--146",

journal = "Aging Clinical and Experimental Research",

issn = "1594-0667",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

AU - Slagboom, P. E.

AU - Uitterlinden, A. G.

AU - Vijg, J.

PY - 1991/6

Y1 - 1991/6

N2 - Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)

AB - Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)

KW - Aging

KW - DNA methylation

KW - MHC

KW - cKi-ras

KW - pituitary gland tumor

UR - http://www.scopus.com/inward/record.url?scp=0025916065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025916065&partnerID=8YFLogxK

U2 - 10.1007/BF03323991

DO - 10.1007/BF03323991

M3 - Article

C2 - 1911902

AN - SCOPUS:0025916065

SN - 1594-0667

VL - 3

SP - 141

EP - 146

JO - Aging Clinical and Experimental Research

JF - Aging Clinical and Experimental Research

IS - 2

ER -

Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this