Methylation status of cKi-ras and MHC genes in rat pituitary glands during aging and tumorigenesis

P. E. Slagboom, A. G. Uitterlinden, Jan Vijg

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Abstract

Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalAging - Clinical and Experimental Research
Volume3
Issue number2
StatePublished - 1991
Externally publishedYes

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Pituitary Gland
Major Histocompatibility Complex
Methylation
Carcinogenesis
Sequence Homology
Genes
Neoplasms

ASJC Scopus subject areas

  • Aging

Cite this

Methylation status of cKi-ras and MHC genes in rat pituitary glands during aging and tumorigenesis. / Slagboom, P. E.; Uitterlinden, A. G.; Vijg, Jan.

In: Aging - Clinical and Experimental Research, Vol. 3, No. 2, 1991, p. 141-146.

Research output: Contribution to journalArticle

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