Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

P. E. Slagboom, A. G. Uitterlinden, J. Vijg

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Abstract

Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalAging Clinical and Experimental Research
Volume3
Issue number2
DOIs
Publication statusPublished - Jun 1991
Externally publishedYes

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Keywords

  • Aging
  • DNA methylation
  • MHC
  • cKi-ras
  • pituitary gland tumor

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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