Methods for pooling results of epidemiologic studies: The pooling project of prospective studies of diet and cancer

Stephanie A. Smith-Warner, Donna Spiegelman, John Ritz, Demetrius Albanes, W. Lawrence Beeson, Leslie Bernstein, Franco Berrino, Piet A. Van Den Brandt, Julie E. Buring, Eunyoung Cho, Graham A. Colditz, Aaron R. Folsom, Jo L. Freudenheim, Edward Giovannucci, R. Alexandra Goldbohm, Saxon Graham, Lisa Harnack, Pamela L. Horn-Ross, Vittorio Krogh, Michael F. LeitzmannMarjorie L. McCullough, Anthony B. Miller, Carmen Rodriguez, Thomas E. Rohan, Arthur Schatzkin, Roy Shore, Mikko Virtanen, Walter C. Willett, Alicja Wolk, Anne Zeleniuch-Jacquotte, Shumin M. Zhang, David J. Hunter

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

With the growing number of epidemiologic publications on the relation between dietary factors and cancer risk, pooled analyses that summarize results from multiple studies are becoming more common. Here, the authors describe the methods being used to summarize data on diet-cancer associations within the ongoing Pooling Project of Prospective Studies of Diet and Cancer, begun in 1991. In the Pooling Project, the primary data from prospective cohort studies meeting prespecified inclusion criteria are analyzed using standardized criteria for modeling of exposure, confounding, and outcome variables. In addition to evaluating main exposure-disease associations, analyses are also conducted to evaluate whether exposure-disease associations are modified by other dietary and nondietary factors or vary among population subgroups or particular cancer subtypes. Study-specific relative risks are calculated using the Cox proportional hazards model and then pooled using a random- or mixed-effects model. The study-specific estimates are weighted by the inverse of their variances in forming summary estimates. Most of the methods used in the Pooling Project may be adapted for examining associations with dietary and nondietary factors in pooled analyses of case-control studies or case-control and cohort studies combined.

Original languageEnglish (US)
Pages (from-to)1053-1064
Number of pages12
JournalAmerican Journal of Epidemiology
Volume163
Issue number11
DOIs
StatePublished - Jun 2006

Fingerprint

Epidemiologic Studies
Prospective Studies
Diet
Case-Control Studies
Neoplasms
Cohort Studies
Confounding Factors (Epidemiology)
Proportional Hazards Models
Publications
Population

Keywords

  • Cohort studies
  • Diet
  • Epidemiologic methods
  • Meta-analysis
  • Neoplasms

ASJC Scopus subject areas

  • Epidemiology

Cite this

Smith-Warner, S. A., Spiegelman, D., Ritz, J., Albanes, D., Beeson, W. L., Bernstein, L., ... Hunter, D. J. (2006). Methods for pooling results of epidemiologic studies: The pooling project of prospective studies of diet and cancer. American Journal of Epidemiology, 163(11), 1053-1064. https://doi.org/10.1093/aje/kwj127

Methods for pooling results of epidemiologic studies : The pooling project of prospective studies of diet and cancer. / Smith-Warner, Stephanie A.; Spiegelman, Donna; Ritz, John; Albanes, Demetrius; Beeson, W. Lawrence; Bernstein, Leslie; Berrino, Franco; Van Den Brandt, Piet A.; Buring, Julie E.; Cho, Eunyoung; Colditz, Graham A.; Folsom, Aaron R.; Freudenheim, Jo L.; Giovannucci, Edward; Goldbohm, R. Alexandra; Graham, Saxon; Harnack, Lisa; Horn-Ross, Pamela L.; Krogh, Vittorio; Leitzmann, Michael F.; McCullough, Marjorie L.; Miller, Anthony B.; Rodriguez, Carmen; Rohan, Thomas E.; Schatzkin, Arthur; Shore, Roy; Virtanen, Mikko; Willett, Walter C.; Wolk, Alicja; Zeleniuch-Jacquotte, Anne; Zhang, Shumin M.; Hunter, David J.

In: American Journal of Epidemiology, Vol. 163, No. 11, 06.2006, p. 1053-1064.

Research output: Contribution to journalArticle

Smith-Warner, SA, Spiegelman, D, Ritz, J, Albanes, D, Beeson, WL, Bernstein, L, Berrino, F, Van Den Brandt, PA, Buring, JE, Cho, E, Colditz, GA, Folsom, AR, Freudenheim, JL, Giovannucci, E, Goldbohm, RA, Graham, S, Harnack, L, Horn-Ross, PL, Krogh, V, Leitzmann, MF, McCullough, ML, Miller, AB, Rodriguez, C, Rohan, TE, Schatzkin, A, Shore, R, Virtanen, M, Willett, WC, Wolk, A, Zeleniuch-Jacquotte, A, Zhang, SM & Hunter, DJ 2006, 'Methods for pooling results of epidemiologic studies: The pooling project of prospective studies of diet and cancer', American Journal of Epidemiology, vol. 163, no. 11, pp. 1053-1064. https://doi.org/10.1093/aje/kwj127
Smith-Warner, Stephanie A. ; Spiegelman, Donna ; Ritz, John ; Albanes, Demetrius ; Beeson, W. Lawrence ; Bernstein, Leslie ; Berrino, Franco ; Van Den Brandt, Piet A. ; Buring, Julie E. ; Cho, Eunyoung ; Colditz, Graham A. ; Folsom, Aaron R. ; Freudenheim, Jo L. ; Giovannucci, Edward ; Goldbohm, R. Alexandra ; Graham, Saxon ; Harnack, Lisa ; Horn-Ross, Pamela L. ; Krogh, Vittorio ; Leitzmann, Michael F. ; McCullough, Marjorie L. ; Miller, Anthony B. ; Rodriguez, Carmen ; Rohan, Thomas E. ; Schatzkin, Arthur ; Shore, Roy ; Virtanen, Mikko ; Willett, Walter C. ; Wolk, Alicja ; Zeleniuch-Jacquotte, Anne ; Zhang, Shumin M. ; Hunter, David J. / Methods for pooling results of epidemiologic studies : The pooling project of prospective studies of diet and cancer. In: American Journal of Epidemiology. 2006 ; Vol. 163, No. 11. pp. 1053-1064.
@article{800c946792bf41cbaf3204a4cd5de658,
title = "Methods for pooling results of epidemiologic studies: The pooling project of prospective studies of diet and cancer",
abstract = "With the growing number of epidemiologic publications on the relation between dietary factors and cancer risk, pooled analyses that summarize results from multiple studies are becoming more common. Here, the authors describe the methods being used to summarize data on diet-cancer associations within the ongoing Pooling Project of Prospective Studies of Diet and Cancer, begun in 1991. In the Pooling Project, the primary data from prospective cohort studies meeting prespecified inclusion criteria are analyzed using standardized criteria for modeling of exposure, confounding, and outcome variables. In addition to evaluating main exposure-disease associations, analyses are also conducted to evaluate whether exposure-disease associations are modified by other dietary and nondietary factors or vary among population subgroups or particular cancer subtypes. Study-specific relative risks are calculated using the Cox proportional hazards model and then pooled using a random- or mixed-effects model. The study-specific estimates are weighted by the inverse of their variances in forming summary estimates. Most of the methods used in the Pooling Project may be adapted for examining associations with dietary and nondietary factors in pooled analyses of case-control studies or case-control and cohort studies combined.",
keywords = "Cohort studies, Diet, Epidemiologic methods, Meta-analysis, Neoplasms",
author = "Smith-Warner, {Stephanie A.} and Donna Spiegelman and John Ritz and Demetrius Albanes and Beeson, {W. Lawrence} and Leslie Bernstein and Franco Berrino and {Van Den Brandt}, {Piet A.} and Buring, {Julie E.} and Eunyoung Cho and Colditz, {Graham A.} and Folsom, {Aaron R.} and Freudenheim, {Jo L.} and Edward Giovannucci and Goldbohm, {R. Alexandra} and Saxon Graham and Lisa Harnack and Horn-Ross, {Pamela L.} and Vittorio Krogh and Leitzmann, {Michael F.} and McCullough, {Marjorie L.} and Miller, {Anthony B.} and Carmen Rodriguez and Rohan, {Thomas E.} and Arthur Schatzkin and Roy Shore and Mikko Virtanen and Willett, {Walter C.} and Alicja Wolk and Anne Zeleniuch-Jacquotte and Zhang, {Shumin M.} and Hunter, {David J.}",
year = "2006",
month = "6",
doi = "10.1093/aje/kwj127",
language = "English (US)",
volume = "163",
pages = "1053--1064",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Methods for pooling results of epidemiologic studies

T2 - The pooling project of prospective studies of diet and cancer

AU - Smith-Warner, Stephanie A.

AU - Spiegelman, Donna

AU - Ritz, John

AU - Albanes, Demetrius

AU - Beeson, W. Lawrence

AU - Bernstein, Leslie

AU - Berrino, Franco

AU - Van Den Brandt, Piet A.

AU - Buring, Julie E.

AU - Cho, Eunyoung

AU - Colditz, Graham A.

AU - Folsom, Aaron R.

AU - Freudenheim, Jo L.

AU - Giovannucci, Edward

AU - Goldbohm, R. Alexandra

AU - Graham, Saxon

AU - Harnack, Lisa

AU - Horn-Ross, Pamela L.

AU - Krogh, Vittorio

AU - Leitzmann, Michael F.

AU - McCullough, Marjorie L.

AU - Miller, Anthony B.

AU - Rodriguez, Carmen

AU - Rohan, Thomas E.

AU - Schatzkin, Arthur

AU - Shore, Roy

AU - Virtanen, Mikko

AU - Willett, Walter C.

AU - Wolk, Alicja

AU - Zeleniuch-Jacquotte, Anne

AU - Zhang, Shumin M.

AU - Hunter, David J.

PY - 2006/6

Y1 - 2006/6

N2 - With the growing number of epidemiologic publications on the relation between dietary factors and cancer risk, pooled analyses that summarize results from multiple studies are becoming more common. Here, the authors describe the methods being used to summarize data on diet-cancer associations within the ongoing Pooling Project of Prospective Studies of Diet and Cancer, begun in 1991. In the Pooling Project, the primary data from prospective cohort studies meeting prespecified inclusion criteria are analyzed using standardized criteria for modeling of exposure, confounding, and outcome variables. In addition to evaluating main exposure-disease associations, analyses are also conducted to evaluate whether exposure-disease associations are modified by other dietary and nondietary factors or vary among population subgroups or particular cancer subtypes. Study-specific relative risks are calculated using the Cox proportional hazards model and then pooled using a random- or mixed-effects model. The study-specific estimates are weighted by the inverse of their variances in forming summary estimates. Most of the methods used in the Pooling Project may be adapted for examining associations with dietary and nondietary factors in pooled analyses of case-control studies or case-control and cohort studies combined.

AB - With the growing number of epidemiologic publications on the relation between dietary factors and cancer risk, pooled analyses that summarize results from multiple studies are becoming more common. Here, the authors describe the methods being used to summarize data on diet-cancer associations within the ongoing Pooling Project of Prospective Studies of Diet and Cancer, begun in 1991. In the Pooling Project, the primary data from prospective cohort studies meeting prespecified inclusion criteria are analyzed using standardized criteria for modeling of exposure, confounding, and outcome variables. In addition to evaluating main exposure-disease associations, analyses are also conducted to evaluate whether exposure-disease associations are modified by other dietary and nondietary factors or vary among population subgroups or particular cancer subtypes. Study-specific relative risks are calculated using the Cox proportional hazards model and then pooled using a random- or mixed-effects model. The study-specific estimates are weighted by the inverse of their variances in forming summary estimates. Most of the methods used in the Pooling Project may be adapted for examining associations with dietary and nondietary factors in pooled analyses of case-control studies or case-control and cohort studies combined.

KW - Cohort studies

KW - Diet

KW - Epidemiologic methods

KW - Meta-analysis

KW - Neoplasms

UR - http://www.scopus.com/inward/record.url?scp=33745608452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745608452&partnerID=8YFLogxK

U2 - 10.1093/aje/kwj127

DO - 10.1093/aje/kwj127

M3 - Article

C2 - 16624970

AN - SCOPUS:33745608452

VL - 163

SP - 1053

EP - 1064

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 11

ER -