Methodology in anti-emetic trials

Richard J. Gralla, R. A. Clark, M. G. Kris, L. B. Tyson

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Major progress in the ability to control chemotherapy-induced emesis has been made over the past 10 years. One of the several factors contributing to this improved control has been the development of accurate assessment methodology. The application of proper study methodology fostered the identification of active single agents and led to the formation of effective anti-emetic combinations. In this communication, important areas in anti-emetic study evaluation will be outlined. Proper methodology includes selection of agents or regimens that have a good rationale for study. Patient, chemotherapy, and anti-emetic factors must be controlled or standardised in good trial design, and the evaluation techniques for determining the amount of emesis or of nausea must be performed using reliable and valid methods. The statistical design employed and number of patients entered in the trial should be determined based on achievable and relevant goals.

Original languageEnglish (US)
JournalEuropean Journal of Cancer
Volume27
Issue numberSUPPL. 1
StatePublished - 1991
Externally publishedYes

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Antiemetics
Vomiting
Drug Therapy
Nausea

ASJC Scopus subject areas

  • Cancer Research

Cite this

Gralla, R. J., Clark, R. A., Kris, M. G., & Tyson, L. B. (1991). Methodology in anti-emetic trials. European Journal of Cancer, 27(SUPPL. 1).

Methodology in anti-emetic trials. / Gralla, Richard J.; Clark, R. A.; Kris, M. G.; Tyson, L. B.

In: European Journal of Cancer, Vol. 27, No. SUPPL. 1, 1991.

Research output: Contribution to journalArticle

Gralla, RJ, Clark, RA, Kris, MG & Tyson, LB 1991, 'Methodology in anti-emetic trials', European Journal of Cancer, vol. 27, no. SUPPL. 1.
Gralla RJ, Clark RA, Kris MG, Tyson LB. Methodology in anti-emetic trials. European Journal of Cancer. 1991;27(SUPPL. 1).
Gralla, Richard J. ; Clark, R. A. ; Kris, M. G. ; Tyson, L. B. / Methodology in anti-emetic trials. In: European Journal of Cancer. 1991 ; Vol. 27, No. SUPPL. 1.
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