Methanol

L. G. Costa, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Methanol (methyl alcohol) has multiple uses, but human poisoning usually occurs as a result of ingesting adulterated wines or liquors. Methanol is converted by alcohol and aldehyde dehydrogenases to formaldehyde and formic acid, respectively; the latter is thought to be responsible for methanol toxicity, which includes metabolic acidosis, visual system toxicity with possible blindness, and other neurological disturbances. Treatment of poisoning consists of inhibiting or delaying methanol metabolism by the use of fomepizole or ethanol. Species with low susceptibility to methanol neurotoxicity (e.g., rodents) can effectively convert formic acid to carbon dioxide.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages1
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

Fingerprint

Methanol
formic acid
Poisoning
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
Wine
Blindness
Acidosis
Carbon Dioxide
Formaldehyde
Rodentia
Ethanol

Keywords

  • Ethanol
  • Fomepizole
  • Formaldehyde
  • Formic acid
  • Metabolic acidosis
  • Methanol
  • Methyl alcohol
  • Retina
  • Visual system toxicity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Costa, L. G., & Aschner, M. (2014). Methanol. In Encyclopedia of the Neurological Sciences Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00265-7

Methanol. / Costa, L. G.; Aschner, Michael.

Encyclopedia of the Neurological Sciences. Elsevier Inc., 2014.

Research output: Chapter in Book/Report/Conference proceedingChapter

Costa, LG & Aschner, M 2014, Methanol. in Encyclopedia of the Neurological Sciences. Elsevier Inc. https://doi.org/10.1016/B978-0-12-385157-4.00265-7
Costa LG, Aschner M. Methanol. In Encyclopedia of the Neurological Sciences. Elsevier Inc. 2014 https://doi.org/10.1016/B978-0-12-385157-4.00265-7
Costa, L. G. ; Aschner, Michael. / Methanol. Encyclopedia of the Neurological Sciences. Elsevier Inc., 2014.
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