Methanol

L. G. Costa, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Methanol (methyl alcohol) has multiple uses, but human poisoning usually occurs as a result of ingesting adulterated wines or liquors. Methanol is converted by alcohol and aldehyde dehydrogenases to formaldehyde and formic acid, respectively; the latter is thought to be responsible for methanol toxicity, which includes metabolic acidosis, visual system toxicity with possible blindness, and other neurological disturbances. Treatment of poisoning consists of inhibiting or delaying methanol metabolism by the use of fomepizole or ethanol. Species with low susceptibility to methanol neurotoxicity (e.g., rodents) can effectively convert formic acid to carbon dioxide.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages1
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

Keywords

  • Ethanol
  • Fomepizole
  • Formaldehyde
  • Formic acid
  • Metabolic acidosis
  • Methanol
  • Methyl alcohol
  • Retina
  • Visual system toxicity

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Methanol'. Together they form a unique fingerprint.

  • Cite this

    Costa, L. G., & Aschner, M. (2014). Methanol. In Encyclopedia of the Neurological Sciences Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00265-7