Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues

Habibullah Peerzada, Jay A. Gandhi, Allan J. Guimaraes, Joshua D. Nosanchuk, Luis R. Martinez

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Methamphetamine (METH) is a potent and highly addictive central nervous system (CNS) stimulant. Additionally, METH adversely impacts immunological responses, which might contribute to the higher rate and more rapid progression of certain infections in drug abusers. However no studies have shown the impact of METH on inflammation within specific organs, cellular participation and cytokine production. Using a murine model of METH administration, we demonstrated that METH modifies, with variable degrees, leukocyte recruitment and alters cellular mediators in the lungs, liver, spleen and kidneys of mice. Our findings demonstrate the pleotropic effects of METH on the immune response within diverse tissues. These alterations have profound implications on tissue homeostasis and the capacity of the host to respond to diverse insults, including invading pathogens.

Original languageEnglish (US)
Pages (from-to)1063-1068
Number of pages6
JournalImmunobiology
Volume218
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • Cytokines
  • Leukocytes
  • Methamphetamine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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