Abstract
Methamphetamine (METH) is a potent and highly addictive central nervous system (CNS) stimulant. Additionally, METH adversely impacts immunological responses, which might contribute to the higher rate and more rapid progression of certain infections in drug abusers. However no studies have shown the impact of METH on inflammation within specific organs, cellular participation and cytokine production. Using a murine model of METH administration, we demonstrated that METH modifies, with variable degrees, leukocyte recruitment and alters cellular mediators in the lungs, liver, spleen and kidneys of mice. Our findings demonstrate the pleotropic effects of METH on the immune response within diverse tissues. These alterations have profound implications on tissue homeostasis and the capacity of the host to respond to diverse insults, including invading pathogens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1063-1068 |
| Number of pages | 6 |
| Journal | Immunobiology |
| Volume | 218 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2013 |
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Keywords
- Cytokines
- Leukocytes
- Methamphetamine
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Hematology
Cite this
Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues. / Peerzada, Habibullah; Gandhi, Jay A.; Guimaraes, Allan J.; Nosanchuk, Joshua D.; Martinez, Luis R.
In: Immunobiology, Vol. 218, No. 8, 08.2013, p. 1063-1068.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues
AU - Peerzada, Habibullah
AU - Gandhi, Jay A.
AU - Guimaraes, Allan J.
AU - Nosanchuk, Joshua D.
AU - Martinez, Luis R.
PY - 2013/8
Y1 - 2013/8
N2 - Methamphetamine (METH) is a potent and highly addictive central nervous system (CNS) stimulant. Additionally, METH adversely impacts immunological responses, which might contribute to the higher rate and more rapid progression of certain infections in drug abusers. However no studies have shown the impact of METH on inflammation within specific organs, cellular participation and cytokine production. Using a murine model of METH administration, we demonstrated that METH modifies, with variable degrees, leukocyte recruitment and alters cellular mediators in the lungs, liver, spleen and kidneys of mice. Our findings demonstrate the pleotropic effects of METH on the immune response within diverse tissues. These alterations have profound implications on tissue homeostasis and the capacity of the host to respond to diverse insults, including invading pathogens.
AB - Methamphetamine (METH) is a potent and highly addictive central nervous system (CNS) stimulant. Additionally, METH adversely impacts immunological responses, which might contribute to the higher rate and more rapid progression of certain infections in drug abusers. However no studies have shown the impact of METH on inflammation within specific organs, cellular participation and cytokine production. Using a murine model of METH administration, we demonstrated that METH modifies, with variable degrees, leukocyte recruitment and alters cellular mediators in the lungs, liver, spleen and kidneys of mice. Our findings demonstrate the pleotropic effects of METH on the immune response within diverse tissues. These alterations have profound implications on tissue homeostasis and the capacity of the host to respond to diverse insults, including invading pathogens.
KW - Cytokines
KW - Leukocytes
KW - Methamphetamine
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UR - http://www.scopus.com/inward/citedby.url?scp=84878615644&partnerID=8YFLogxK
U2 - 10.1016/j.imbio.2013.02.001
DO - 10.1016/j.imbio.2013.02.001
M3 - Article
C2 - 23518444
AN - SCOPUS:84878615644
VL - 218
SP - 1063
EP - 1068
JO - Immunobiology
JF - Immunobiology
SN - 0171-2985
IS - 8
ER -