Metastatic squamous cell carcinoma in a northern brown bandicoot (Isoodon macrourus)

Amanda P. Beck, Amy L. Shima, Mark D. Bennett, Linda K. Johnson

Research output: Contribution to journalArticle

Abstract

Aside from a handful of notable exceptions, neoplasia is not reported as a major cause of mortality in wild animal populations and often goes undetected. For northern brown bandicoots specifically, there are few reported tumors in the literature and on file in the Australian Registry of Wildlife Health. This report describes a case of squamous cell carcinoma in a northern brown bandicoot (Isoodon macrourus), with metastases to the draining lymph nodes and lung. This neoplasm consisted predominantly of well-differentiated squamous cells and multifocal keratin pearls, with areas possibly consistent with epithelial to mesenchymal transition, as identified by positive immunohistochemical staining by both pancytokeratin (AE1/AE3) and vimentin. Additional investigations were negative for bandicoot papillomatosis carcinomatosis viruses.

Original languageEnglish (US)
Article number10
JournalVeterinary Sciences
Volume4
Issue number1
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Fingerprint

squamous cell carcinoma
Squamous Cell Carcinoma
neoplasms
Neoplasms
papilloma
Wild Animals
Epithelial-Mesenchymal Transition
pearls
keratin
vimentin
Papilloma
Vimentin
wild animals
Keratins
metastasis
lymph nodes
Registries
wildlife
Lymph Nodes
Epithelial Cells

Keywords

  • Epithelial to mesenchymal transition
  • Immunohistochemistry
  • Isoodon macrourus
  • Neoplasia
  • Northern brown bandicoot
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Metastatic squamous cell carcinoma in a northern brown bandicoot (Isoodon macrourus). / Beck, Amanda P.; Shima, Amy L.; Bennett, Mark D.; Johnson, Linda K.

In: Veterinary Sciences, Vol. 4, No. 1, 10, 01.03.2017.

Research output: Contribution to journalArticle

Beck, Amanda P. ; Shima, Amy L. ; Bennett, Mark D. ; Johnson, Linda K. / Metastatic squamous cell carcinoma in a northern brown bandicoot (Isoodon macrourus). In: Veterinary Sciences. 2017 ; Vol. 4, No. 1.
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