Metastasis

Tumor cells becoming MENAcing

Frank Gertler, John S. Condeelis

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

During breast cancer metastasis cells emigrate from the primary tumor to the bloodstream, and this carries them to distant sites where they infiltrate and sometimes form metastases within target organs. These cells must penetrate the dense extracellular matrix comprising the basement membrane of the mammary duct/acinus and migrate toward blood and lymphatic vessels, processes that mammary tumor cells execute primarily using epidermal growth factor (EGF)-dependent protrusive and migratory activity. Here, we focus on how the actin regulatory protein Mena affects EGF-elicited movement, invasion and metastasis. Recent findings indicate that, in invasive migratory tumor cells, Mena isoforms that endow heightened sensitivity to EGF and increased protrusive and migratory abilities are upregulated, whereas other isoforms are selectively downregulated. This change in Mena isoform expression enables tumor cells to invade in response to otherwise benign EGF stimulus levels and could offer an opportunity to identify metastatic risk in patients.

Original languageEnglish (US)
Pages (from-to)81-90
Number of pages10
JournalTrends in Cell Biology
Volume21
Issue number2
DOIs
StatePublished - Feb 2011

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Epidermal Growth Factor
Neoplasm Metastasis
Protein Isoforms
Neoplasms
Breast Neoplasms
Lymphatic Vessels
Basement Membrane
Extracellular Matrix
Blood Vessels
Actins
Breast
Down-Regulation
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Metastasis : Tumor cells becoming MENAcing. / Gertler, Frank; Condeelis, John S.

In: Trends in Cell Biology, Vol. 21, No. 2, 02.2011, p. 81-90.

Research output: Contribution to journalArticle

Gertler, Frank ; Condeelis, John S. / Metastasis : Tumor cells becoming MENAcing. In: Trends in Cell Biology. 2011 ; Vol. 21, No. 2. pp. 81-90.
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