TY - JOUR
T1 - Metastasis
T2 - Tumor cells becoming MENAcing
AU - Gertler, Frank
AU - Condeelis, John
N1 - Funding Information:
This work is supported by grants from the National Cancer Institute (CA100324, CA150344, CA113395, CA126511) to J.C. and from the National Institutes of Health (GM58801), the Integrated Cancer Biology Program (1-U54-CA11296), and by funds from the Ludwig Center for Metastasis Research at MIT to F.B.G. We thank Shannon Alford and Stephanie Gupton for contributing the images in Figure 2 , and Scott Hansen and Dyche Mullins for sharing results prior to publication.
PY - 2011/2
Y1 - 2011/2
N2 - During breast cancer metastasis cells emigrate from the primary tumor to the bloodstream, and this carries them to distant sites where they infiltrate and sometimes form metastases within target organs. These cells must penetrate the dense extracellular matrix comprising the basement membrane of the mammary duct/acinus and migrate toward blood and lymphatic vessels, processes that mammary tumor cells execute primarily using epidermal growth factor (EGF)-dependent protrusive and migratory activity. Here, we focus on how the actin regulatory protein Mena affects EGF-elicited movement, invasion and metastasis. Recent findings indicate that, in invasive migratory tumor cells, Mena isoforms that endow heightened sensitivity to EGF and increased protrusive and migratory abilities are upregulated, whereas other isoforms are selectively downregulated. This change in Mena isoform expression enables tumor cells to invade in response to otherwise benign EGF stimulus levels and could offer an opportunity to identify metastatic risk in patients.
AB - During breast cancer metastasis cells emigrate from the primary tumor to the bloodstream, and this carries them to distant sites where they infiltrate and sometimes form metastases within target organs. These cells must penetrate the dense extracellular matrix comprising the basement membrane of the mammary duct/acinus and migrate toward blood and lymphatic vessels, processes that mammary tumor cells execute primarily using epidermal growth factor (EGF)-dependent protrusive and migratory activity. Here, we focus on how the actin regulatory protein Mena affects EGF-elicited movement, invasion and metastasis. Recent findings indicate that, in invasive migratory tumor cells, Mena isoforms that endow heightened sensitivity to EGF and increased protrusive and migratory abilities are upregulated, whereas other isoforms are selectively downregulated. This change in Mena isoform expression enables tumor cells to invade in response to otherwise benign EGF stimulus levels and could offer an opportunity to identify metastatic risk in patients.
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U2 - 10.1016/j.tcb.2010.10.001
DO - 10.1016/j.tcb.2010.10.001
M3 - Review article
C2 - 21071226
AN - SCOPUS:79151474408
SN - 0962-8924
VL - 21
SP - 81
EP - 90
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -