Metals and Neurodegeneration

Pan Chen, Mahfuzur Rahman Miah, Michael Aschner

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain-Barré disease, Gulf War syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and Wilson's disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.

Original languageEnglish (US)
Article number7431.1
JournalF1000Research
Volume5
DOIs
StatePublished - 2016

Fingerprint

Metals
Persian Gulf Syndrome
Hepatolenticular Degeneration
Poisons
Huntington Disease
Amyotrophic Lateral Sclerosis
Nervous System Diseases
Oxidative stress
Human Body
Synaptic Transmission
Nervous System
Multiple Sclerosis
Neurology
Names
Parkinson Disease
Epidemiologic Studies
Alzheimer Disease
Gene expression
Oxidative Stress
Antioxidants

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Metals and Neurodegeneration. / Chen, Pan; Miah, Mahfuzur Rahman; Aschner, Michael.

In: F1000Research, Vol. 5, 7431.1, 2016.

Research output: Contribution to journalArticle

Chen, Pan ; Miah, Mahfuzur Rahman ; Aschner, Michael. / Metals and Neurodegeneration. In: F1000Research. 2016 ; Vol. 5.
@article{9d8ee83f73924b7184ffdf58f1c2859b,
title = "Metals and Neurodegeneration",
abstract = "Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain-Barr{\'e} disease, Gulf War syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and Wilson's disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.",
author = "Pan Chen and Miah, {Mahfuzur Rahman} and Michael Aschner",
year = "2016",
doi = "10.12688/f1000research.7431.1",
language = "English (US)",
volume = "5",
journal = "F1000Research",
issn = "2046-1402",
publisher = "F1000 Research Ltd.",

}

TY - JOUR

T1 - Metals and Neurodegeneration

AU - Chen, Pan

AU - Miah, Mahfuzur Rahman

AU - Aschner, Michael

PY - 2016

Y1 - 2016

N2 - Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain-Barré disease, Gulf War syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and Wilson's disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.

AB - Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain-Barré disease, Gulf War syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and Wilson's disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.

UR - http://www.scopus.com/inward/record.url?scp=84964692730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964692730&partnerID=8YFLogxK

U2 - 10.12688/f1000research.7431.1

DO - 10.12688/f1000research.7431.1

M3 - Article

AN - SCOPUS:84964692730

VL - 5

JO - F1000Research

JF - F1000Research

SN - 2046-1402

M1 - 7431.1

ER -