Metals and Autophagy in Neurotoxicity

Peng Su, Michael Aschner, Jingyuan Chen, Wenjing Luo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Metal ions have a great effect on the function of the central nervous system. Exposure to abnormal concentrations of essential metals, such as manganese, copper, and iron, or heavy metals, such as cadmium, lead, and mercury, will trigger neurotoxicity. Mounting evidence implicated metal neurotoxicity in the progress of neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, etc. Autophagy plays a significant role in maintaining cellular homeostasis and protects cells from varying insults, including misfolded and aggregated proteins and damaged organelles, which is particularly crucial in neuronal survival. Autophagy has also been found to affect neurotoxicity induced by exposure to metals. This review examines current literature on the role of metals in the mechanisms of disease pathogenesis among common neurodegenerative disorders and role of autophagy in metal-induced neurotoxicity.

Original languageEnglish (US)
Title of host publicationBiometals in Neurodegenerative Diseases
Subtitle of host publicationMechanisms and Therapeutics
PublisherElsevier Inc.
Pages377-398
Number of pages22
ISBN (Electronic)9780128045633
ISBN (Print)9780128045626
DOIs
Publication statusPublished - Apr 28 2017

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Keywords

  • Autophagy
  • Metals
  • Neurodegenerative disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Su, P., Aschner, M., Chen, J., & Luo, W. (2017). Metals and Autophagy in Neurotoxicity. In Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics (pp. 377-398). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804562-6.00019-1