Metals and Autophagy in Neurotoxicity

Peng Su; Michael Aschner; Jingyuan Chen; Wenjing Luo

doi:10.1016/B978-0-12-804562-6.00019-1

Metals and Autophagy in Neurotoxicity

Peng Su, Michael Aschner, Jingyuan Chen, Wenjing Luo

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Metal ions have a great effect on the function of the central nervous system. Exposure to abnormal concentrations of essential metals, such as manganese, copper, and iron, or heavy metals, such as cadmium, lead, and mercury, will trigger neurotoxicity. Mounting evidence implicated metal neurotoxicity in the progress of neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, etc. Autophagy plays a significant role in maintaining cellular homeostasis and protects cells from varying insults, including misfolded and aggregated proteins and damaged organelles, which is particularly crucial in neuronal survival. Autophagy has also been found to affect neurotoxicity induced by exposure to metals. This review examines current literature on the role of metals in the mechanisms of disease pathogenesis among common neurodegenerative disorders and role of autophagy in metal-induced neurotoxicity.

Original language	English (US)
Title of host publication	Biometals in Neurodegenerative Diseases
Subtitle of host publication	Mechanisms and Therapeutics
Publisher	Elsevier Inc.
Pages	377-398
Number of pages	22
ISBN (Electronic)	9780128045633
ISBN (Print)	9780128045626
DOIs	https://doi.org/10.1016/B978-0-12-804562-6.00019-1
State	Published - Apr 28 2017

Keywords

Autophagy
Metals
Neurodegenerative disease

ASJC Scopus subject areas

General Neuroscience
General Medicine

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10.1016/B978-0-12-804562-6.00019-1

Cite this

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AU - Luo, Wenjing

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Metals and Autophagy in Neurotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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