Metal ions have a great effect on the function of the central nervous system. Exposure to abnormal concentrations of essential metals, such as manganese, copper, and iron, or heavy metals, such as cadmium, lead, and mercury, will trigger neurotoxicity. Mounting evidence implicated metal neurotoxicity in the progress of neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, etc. Autophagy plays a significant role in maintaining cellular homeostasis and protects cells from varying insults, including misfolded and aggregated proteins and damaged organelles, which is particularly crucial in neuronal survival. Autophagy has also been found to affect neurotoxicity induced by exposure to metals. This review examines current literature on the role of metals in the mechanisms of disease pathogenesis among common neurodegenerative disorders and role of autophagy in metal-induced neurotoxicity.
|Original language||English (US)|
|Title of host publication||Biometals in Neurodegenerative Diseases|
|Subtitle of host publication||Mechanisms and Therapeutics|
|Number of pages||22|
|State||Published - Apr 28 2017|
- Neurodegenerative disease
ASJC Scopus subject areas