Metallothioneins: Mercury species-specific induction and their potential role in attenuating neurotoxicity

Michael Aschner, Tore Syversen, Diogo O. Souza, Joao B T Rocha

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Metallothionein (MT) proteins are widespread in bacteria, fungi, plants, and eukaryotic species. They are of low molecular weight (6-7 kDa) and of the 60+ amino acid residues, 20 are cysteines. Functions attributed to MTs include the sequestration and dispersal of metal ions, primarily in zinc and copper homeostasis; regulation of the biosynthesis and activity of zinc metalloproteins, most notably zinc-dependent transcription factors; and cellular cytoprotection from reactive oxygen species, ionizing radiation, electrophilic anticancer drugs and mutagens, and metals. Observations on the abundance of MTs within the central nervous system (CNS) and the identification of a brain-specific isoform, MT-III, suggest that it might have important neurophysiological and neuromodulatory functions. Reinforced by the potential involvement of MT-III in a number of neurodegenerative disorders, the role of MTs in the CNS has become an intense focus of scientific pursuit. This manuscript represents a survey on the ability of MTs to modulate mercury neurotoxicity, a neurotoxin that has been implied to play an etiologic role in Minamata disease, erethism, and autism, just to name a few.

Original languageEnglish (US)
Pages (from-to)1468-1473
Number of pages6
JournalExperimental Biology and Medicine
Volume231
Issue number9
StatePublished - 2006
Externally publishedYes

Fingerprint

Metallothionein
Mercury
Zinc
Neurology
Nervous System Mercury Poisoning
Central Nervous System
Metals
Metalloproteins
Aptitude
Cytoprotection
Biosynthesis
Ionizing radiation
Neurotoxins
Mutagens
Autistic Disorder
Ionizing Radiation
Fungi
Neurodegenerative Diseases
Names
Metal ions

Keywords

  • Mercury
  • Metallothionein
  • Neurotoxicity

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Metallothioneins : Mercury species-specific induction and their potential role in attenuating neurotoxicity. / Aschner, Michael; Syversen, Tore; Souza, Diogo O.; Rocha, Joao B T.

In: Experimental Biology and Medicine, Vol. 231, No. 9, 2006, p. 1468-1473.

Research output: Contribution to journalArticle

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