Metallothioneins in brain - The role in physiology and pathology

Michael Aschner, M. G. Cherian, C. D. Klaassen, R. D. Palmiter, J. C. Erickson, A. I. Bush

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

A symposium on the role of brain metallothioneins (MTs) in physiology and pathology was held at the 1996 Annual Society of Toxicology Meeting in Anaheim, California. The objectives of this symposium were to: (1) review the physiologic function of MTs, (2) examine the distribution of brain MTs with particular emphasis on cell-specific localization (neurons vs neuroglia), (3) discuss MT gene responsiveness upon toxic insult with metals, and (4) discuss the potential role of MTs in the etiology of neurodegenerative disorders. Dr. Cherian discussed the biochemical properties of the MTs, emphasizing structural similarities and differences between the MTs. Dr. Klaassen addressed the expression and distribution of the MTs in brains with special reference to the cell-specific localization of MTs. Dr. Aschner provided data illustrating a potential role for MTs in attenuating the cytotoxicity caused by methylmercury (MeHg) in cultured neonatal astrocytes. Dr. Palmiter discussed the properties of MT-III and the increased sensitivity of MT-III knockout mice to kainate-induced seizures. Cerebral zinc metabolism, its relationship to MT homeostasis, and its pathogenic potential in Alzheimer's disease was addressed by Dr. Bush.

Original languageEnglish (US)
Pages (from-to)229-242
Number of pages14
JournalToxicology and Applied Pharmacology
Volume142
Issue number2
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Metallothionein
Physiology
Pathology
Brain
Kainic Acid
Poisons
Cytotoxicity
Metabolism
Knockout Mice
Neuroglia
Astrocytes
Neurodegenerative Diseases
Neurons
Zinc
Alzheimer Disease
Seizures
Homeostasis
Genes
Metals
growth inhibitory factor

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Aschner, M., Cherian, M. G., Klaassen, C. D., Palmiter, R. D., Erickson, J. C., & Bush, A. I. (1997). Metallothioneins in brain - The role in physiology and pathology. Toxicology and Applied Pharmacology, 142(2), 229-242. https://doi.org/10.1006/taap.1996.8054

Metallothioneins in brain - The role in physiology and pathology. / Aschner, Michael; Cherian, M. G.; Klaassen, C. D.; Palmiter, R. D.; Erickson, J. C.; Bush, A. I.

In: Toxicology and Applied Pharmacology, Vol. 142, No. 2, 1997, p. 229-242.

Research output: Contribution to journalArticle

Aschner, M, Cherian, MG, Klaassen, CD, Palmiter, RD, Erickson, JC & Bush, AI 1997, 'Metallothioneins in brain - The role in physiology and pathology', Toxicology and Applied Pharmacology, vol. 142, no. 2, pp. 229-242. https://doi.org/10.1006/taap.1996.8054
Aschner, Michael ; Cherian, M. G. ; Klaassen, C. D. ; Palmiter, R. D. ; Erickson, J. C. ; Bush, A. I. / Metallothioneins in brain - The role in physiology and pathology. In: Toxicology and Applied Pharmacology. 1997 ; Vol. 142, No. 2. pp. 229-242.
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