Metallothionein and autism

Sarah E. Owens, Marshall L. Summar, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Autism is a complex disorder with both genetic and environmental factors. Metal disturbances have been reported in autistic individuals. In particular, exposure to ethylmercury (EtHg) in the vaccine preservative thimerosal and exposure to methylmercury (MeHg) through fish consumption have been implicated as environmental contributors to the autism spectrum disorder (ASD) phenotype. Metallothioneins (MTs) are small sulfhydryl (-SH)-rich metal-binding proteins that have important functions in metal homeostasis and protection against metalinduced toxicity. MT1 and MT2 have a high affinity for toxic heavy metals and are induced following mercury (Hg) exposure. It has been suggested that altered or dysfunctional MTs could enhance susceptibility to Hg-induced toxicity, and that alterations in Hg metabolism may contribute to the neurodevelopmental phenotypes present in ASD. One proposed treatment of autism is to attempt to restore MT function; however, there is no evidence in the peer-reviewed literature that MT restoration is an effective treatment for autistic symptoms. To date, there is no evidence for the efficacy of MT in ameliorating MeHg-or EtHg-induced neurotoxicity. Currently, there is nothing in the literature that suggests altered MT homeostasis is a contributing factor to the development of autism.

Original languageEnglish (US)
Title of host publicationMetallothioneins in Biochemistry and Pathology
PublisherWorld Scientific Publishing Co.
Pages93-116
Number of pages24
ISBN (Print)9789812778949, 9812778934, 9789812778932
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Keywords

  • Autism
  • Ethylmercury
  • Mercury
  • Metallothionein
  • Metals
  • Methylmercury

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Metallothionein and autism'. Together they form a unique fingerprint.

  • Cite this

    Owens, S. E., Summar, M. L., & Aschner, M. (2008). Metallothionein and autism. In Metallothioneins in Biochemistry and Pathology (pp. 93-116). World Scientific Publishing Co.. https://doi.org/10.1142/9789812778949_0005