Metal Toxicology

Ebany J. Martinez-Finley, Sam Caito, Stephanie Fretham, Pan Chen, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Metals are widespread in the environment due to their presence in the Earth's crust and their use in anthropogenic applications. Waste runoff, eruption of volcanoes and the erosion of natural deposits are the most prominent natural sources. Metals can interact with many cellular components, leading to their toxicity in human cells and causing a variety of effects ranging from neurological diseases and cancer to death. Metals have been used for centuries because of their distinct properties. In this chapter, an overview will be provided of the effects of exposure to metals on human health, and their distribution and metabolism in the body will be described. The properties of metals that determine their reactivity and deleterious biological effects will also be depicted, and their mechanisms of action, whether the disruption of cell signaling and oxidative stress or the disruption of proteins and DNA, will be explored. A description of the methodologies and technologies used to study metals and to detect their presence in biological systems will also be provided.

Original languageEnglish (US)
Title of host publicationMammalian Toxicology
PublisherWiley Blackwell
Pages171-185
Number of pages15
ISBN (Electronic)9781118683484
ISBN (Print)9781119940418
DOIs
StatePublished - Mar 27 2015
Externally publishedYes

Fingerprint

Metals
Cell signaling
Volcanoes
Oxidative stress
Biological systems
Runoff
Metabolism
Toxicity
Erosion
DNA
Deposits
Earth (planet)
Cells
Health
Proteins

Keywords

  • Administration
  • Arsenic
  • Distribution
  • Human health effects
  • Mercury
  • Metals
  • Oxidative stress
  • Zinc

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Martinez-Finley, E. J., Caito, S., Fretham, S., Chen, P., & Aschner, M. (2015). Metal Toxicology. In Mammalian Toxicology (pp. 171-185). Wiley Blackwell. https://doi.org/10.1002/9781118683484.ch8

Metal Toxicology. / Martinez-Finley, Ebany J.; Caito, Sam; Fretham, Stephanie; Chen, Pan; Aschner, Michael.

Mammalian Toxicology. Wiley Blackwell, 2015. p. 171-185.

Research output: Chapter in Book/Report/Conference proceedingChapter

Martinez-Finley, EJ, Caito, S, Fretham, S, Chen, P & Aschner, M 2015, Metal Toxicology. in Mammalian Toxicology. Wiley Blackwell, pp. 171-185. https://doi.org/10.1002/9781118683484.ch8
Martinez-Finley EJ, Caito S, Fretham S, Chen P, Aschner M. Metal Toxicology. In Mammalian Toxicology. Wiley Blackwell. 2015. p. 171-185 https://doi.org/10.1002/9781118683484.ch8
Martinez-Finley, Ebany J. ; Caito, Sam ; Fretham, Stephanie ; Chen, Pan ; Aschner, Michael. / Metal Toxicology. Mammalian Toxicology. Wiley Blackwell, 2015. pp. 171-185
@inbook{8d9f582548f543a0ab701abe9e95ed29,
title = "Metal Toxicology",
abstract = "Metals are widespread in the environment due to their presence in the Earth's crust and their use in anthropogenic applications. Waste runoff, eruption of volcanoes and the erosion of natural deposits are the most prominent natural sources. Metals can interact with many cellular components, leading to their toxicity in human cells and causing a variety of effects ranging from neurological diseases and cancer to death. Metals have been used for centuries because of their distinct properties. In this chapter, an overview will be provided of the effects of exposure to metals on human health, and their distribution and metabolism in the body will be described. The properties of metals that determine their reactivity and deleterious biological effects will also be depicted, and their mechanisms of action, whether the disruption of cell signaling and oxidative stress or the disruption of proteins and DNA, will be explored. A description of the methodologies and technologies used to study metals and to detect their presence in biological systems will also be provided.",
keywords = "Administration, Arsenic, Distribution, Human health effects, Mercury, Metals, Oxidative stress, Zinc",
author = "Martinez-Finley, {Ebany J.} and Sam Caito and Stephanie Fretham and Pan Chen and Michael Aschner",
year = "2015",
month = "3",
day = "27",
doi = "10.1002/9781118683484.ch8",
language = "English (US)",
isbn = "9781119940418",
pages = "171--185",
booktitle = "Mammalian Toxicology",
publisher = "Wiley Blackwell",

}

TY - CHAP

T1 - Metal Toxicology

AU - Martinez-Finley, Ebany J.

AU - Caito, Sam

AU - Fretham, Stephanie

AU - Chen, Pan

AU - Aschner, Michael

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Metals are widespread in the environment due to their presence in the Earth's crust and their use in anthropogenic applications. Waste runoff, eruption of volcanoes and the erosion of natural deposits are the most prominent natural sources. Metals can interact with many cellular components, leading to their toxicity in human cells and causing a variety of effects ranging from neurological diseases and cancer to death. Metals have been used for centuries because of their distinct properties. In this chapter, an overview will be provided of the effects of exposure to metals on human health, and their distribution and metabolism in the body will be described. The properties of metals that determine their reactivity and deleterious biological effects will also be depicted, and their mechanisms of action, whether the disruption of cell signaling and oxidative stress or the disruption of proteins and DNA, will be explored. A description of the methodologies and technologies used to study metals and to detect their presence in biological systems will also be provided.

AB - Metals are widespread in the environment due to their presence in the Earth's crust and their use in anthropogenic applications. Waste runoff, eruption of volcanoes and the erosion of natural deposits are the most prominent natural sources. Metals can interact with many cellular components, leading to their toxicity in human cells and causing a variety of effects ranging from neurological diseases and cancer to death. Metals have been used for centuries because of their distinct properties. In this chapter, an overview will be provided of the effects of exposure to metals on human health, and their distribution and metabolism in the body will be described. The properties of metals that determine their reactivity and deleterious biological effects will also be depicted, and their mechanisms of action, whether the disruption of cell signaling and oxidative stress or the disruption of proteins and DNA, will be explored. A description of the methodologies and technologies used to study metals and to detect their presence in biological systems will also be provided.

KW - Administration

KW - Arsenic

KW - Distribution

KW - Human health effects

KW - Mercury

KW - Metals

KW - Oxidative stress

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=84976598941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976598941&partnerID=8YFLogxK

U2 - 10.1002/9781118683484.ch8

DO - 10.1002/9781118683484.ch8

M3 - Chapter

AN - SCOPUS:84976598941

SN - 9781119940418

SP - 171

EP - 185

BT - Mammalian Toxicology

PB - Wiley Blackwell

ER -