Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM2.5 exposure in mice

Jian Cui, You Fu, Runze Lu, Yuan Bi, Li Zhang, Chengcheng Zhang, Michael Aschner, Xiaobo Li, Rui Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Reproductive epidemiological studies have suggested associations between perinatal exposure to fine particulate matter (PM2.5) and adverse birth outcomes. To explore the effects of early prenatal exposure to PM2.5 on subsequent generations, pregnant mice were exposed to PM2.5 or filtered clean air in whole body dynamic exposure chambers for 14 consecutive days from gestation day (GD) 1.5 to GD15.5. Neurobehavioral tests showed that spontaneous locomotion and exploratory behaviors in the offspring were significantly enhanced in the open field test. Meanwhile, metabolomics analysis suggested activation of dopamine pathway while inhibition of glycine pathway in murine brains. Administration of the DRD4 antagonist, clozapine; or supplementation of glycine receptor agonist, taurine, to mice offspring attenuated the locomotor hyperactivities to levels indistinguishable from controls. These data provide strong evidence that maternal exposure to air pollution might increase the risk for neural disorders in the offspring during critical periods of brain development.

Original languageEnglish (US)
Pages (from-to)687-695
Number of pages9
JournalEcotoxicology and Environmental Safety
Volume169
DOIs
StatePublished - Mar 1 2019

Fingerprint

Maternal Exposure
Metabolomics
Amino acids
Brain
Activation analysis
Glycine Receptors
Activation Analysis
Exploratory Behavior
Particulate Matter
Clozapine
Taurine
Air Pollution
Locomotion
Air pollution
Glycine
Epidemiologic Studies
Dopamine
Air
Parturition
Pregnancy

Keywords

  • Locomotor activity
  • Maternal exposure
  • Metabolomics
  • PM

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM2.5 exposure in mice. / Cui, Jian; Fu, You; Lu, Runze; Bi, Yuan; Zhang, Li; Zhang, Chengcheng; Aschner, Michael; Li, Xiaobo; Chen, Rui.

In: Ecotoxicology and Environmental Safety, Vol. 169, 01.03.2019, p. 687-695.

Research output: Contribution to journalArticle

Cui, Jian ; Fu, You ; Lu, Runze ; Bi, Yuan ; Zhang, Li ; Zhang, Chengcheng ; Aschner, Michael ; Li, Xiaobo ; Chen, Rui. / Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM2.5 exposure in mice. In: Ecotoxicology and Environmental Safety. 2019 ; Vol. 169. pp. 687-695.
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