The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 days in normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.
|Original language||English (US)|
|Number of pages||4|
|Publication status||Published - Dec 1 1965|
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