Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man

Jack H. Oppenheimer, Martin I. Surks, J. Gerald Bernstein, Crispin Smith

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Abstract

The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 days in normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.

Original languageEnglish (US)
Pages (from-to)748-751
Number of pages4
JournalScience
Volume149
Issue number3685
Publication statusPublished - Dec 1 1965

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Cite this

Oppenheimer, J. H., Surks, M. I., Gerald Bernstein, J., & Smith, C. (1965). Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man. Science, 149(3685), 748-751.