TY - JOUR
T1 - Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man
AU - Oppenheimer, Jack H.
AU - Surks, Martin I.
AU - Gerald Bernstein, J.
AU - Smith, Crispin
PY - 1965
Y1 - 1965
N2 - The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 days in normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.
AB - The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 days in normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.
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U2 - 10.1126/science.149.3685.748
DO - 10.1126/science.149.3685.748
M3 - Article
C2 - 14330531
AN - SCOPUS:0013607258
SN - 0036-8075
VL - 149
SP - 748
EP - 751
JO - Science
JF - Science
IS - 3685
ER -