Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man

Jack H. Oppenheimer, Martin I. Surks, J. Gerald Bernstein, Crispin Smith

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 days in normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.

Original languageEnglish (US)
Pages (from-to)748-751
Number of pages4
JournalScience
Volume149
Issue number3685
StatePublished - 1965

Fingerprint

Prealbumin
Thyroxine
Iodine
Serum

ASJC Scopus subject areas

  • General

Cite this

Oppenheimer, J. H., Surks, M. I., Gerald Bernstein, J., & Smith, C. (1965). Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man. Science, 149(3685), 748-751.

Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man. / Oppenheimer, Jack H.; Surks, Martin I.; Gerald Bernstein, J.; Smith, Crispin.

In: Science, Vol. 149, No. 3685, 1965, p. 748-751.

Research output: Contribution to journalArticle

Oppenheimer, JH, Surks, MI, Gerald Bernstein, J & Smith, C 1965, 'Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man', Science, vol. 149, no. 3685, pp. 748-751.
Oppenheimer JH, Surks MI, Gerald Bernstein J, Smith C. Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man. Science. 1965;149(3685):748-751.
Oppenheimer, Jack H. ; Surks, Martin I. ; Gerald Bernstein, J. ; Smith, Crispin. / Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man. In: Science. 1965 ; Vol. 149, No. 3685. pp. 748-751.
@article{a974d90f84a04e1f9e52eabc60bbf4c4,
title = "Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man",
abstract = "The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 days in normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.",
author = "Oppenheimer, {Jack H.} and Surks, {Martin I.} and {Gerald Bernstein}, J. and Crispin Smith",
year = "1965",
language = "English (US)",
volume = "149",
pages = "748--751",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "3685",

}

TY - JOUR

T1 - Metabolism of iodine-131 - labeled thyroxine-bindlng prealbumin in man

AU - Oppenheimer, Jack H.

AU - Surks, Martin I.

AU - Gerald Bernstein, J.

AU - Smith, Crispin

PY - 1965

Y1 - 1965

N2 - The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 days in normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.

AB - The metabolism of 131I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 days in normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.

UR - http://www.scopus.com/inward/record.url?scp=0013607258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013607258&partnerID=8YFLogxK

M3 - Article

VL - 149

SP - 748

EP - 751

JO - Science

JF - Science

SN - 0036-8075

IS - 3685

ER -