Metabolie labeling of sialic acids in living animals with alkynyl sugars

Pamela V. Chang, Xing Chen, Chris Smyrniotis, Alexander Xenakis, Tianshun Hu, Carolyn R. Bertozzi, Peng Wu

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

Original languageEnglish (US)
Pages (from-to)4030-4033
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number22
DOIs
StatePublished - May 18 2009

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Chang, P. V., Chen, X., Smyrniotis, C., Xenakis, A., Hu, T., Bertozzi, C. R., & Wu, P. (2009). Metabolie labeling of sialic acids in living animals with alkynyl sugars. Angewandte Chemie - International Edition, 48(22), 4030-4033. https://doi.org/10.1002/anie.200806319