Metabolie labeling of sialic acids in living animals with alkynyl sugars

Pamela V. Chang, Xing Chen, Chris Smyrniotis, Alexander Xenakis, Tianshun Hu, Carolyn R. Bertozzi, Peng Wu

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

Original languageEnglish (US)
Pages (from-to)4030-4033
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number22
DOIs
StatePublished - May 18 2009

Fingerprint

Sialic Acids
Glycoproteins
Sugars
Labeling
Animals
Tissue
Acids
Biomarkers
Pathogens
Labels
mannosamine

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Chang, P. V., Chen, X., Smyrniotis, C., Xenakis, A., Hu, T., Bertozzi, C. R., & Wu, P. (2009). Metabolie labeling of sialic acids in living animals with alkynyl sugars. Angewandte Chemie - International Edition, 48(22), 4030-4033. https://doi.org/10.1002/anie.200806319

Metabolie labeling of sialic acids in living animals with alkynyl sugars. / Chang, Pamela V.; Chen, Xing; Smyrniotis, Chris; Xenakis, Alexander; Hu, Tianshun; Bertozzi, Carolyn R.; Wu, Peng.

In: Angewandte Chemie - International Edition, Vol. 48, No. 22, 18.05.2009, p. 4030-4033.

Research output: Contribution to journalArticle

Chang, PV, Chen, X, Smyrniotis, C, Xenakis, A, Hu, T, Bertozzi, CR & Wu, P 2009, 'Metabolie labeling of sialic acids in living animals with alkynyl sugars', Angewandte Chemie - International Edition, vol. 48, no. 22, pp. 4030-4033. https://doi.org/10.1002/anie.200806319
Chang PV, Chen X, Smyrniotis C, Xenakis A, Hu T, Bertozzi CR et al. Metabolie labeling of sialic acids in living animals with alkynyl sugars. Angewandte Chemie - International Edition. 2009 May 18;48(22):4030-4033. https://doi.org/10.1002/anie.200806319
Chang, Pamela V. ; Chen, Xing ; Smyrniotis, Chris ; Xenakis, Alexander ; Hu, Tianshun ; Bertozzi, Carolyn R. ; Wu, Peng. / Metabolie labeling of sialic acids in living animals with alkynyl sugars. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 22. pp. 4030-4033.
@article{3d891c3396b04411a2866bc1754cbd96,
title = "Metabolie labeling of sialic acids in living animals with alkynyl sugars",
abstract = "Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.",
author = "Chang, {Pamela V.} and Xing Chen and Chris Smyrniotis and Alexander Xenakis and Tianshun Hu and Bertozzi, {Carolyn R.} and Peng Wu",
year = "2009",
month = "5",
day = "18",
doi = "10.1002/anie.200806319",
language = "English (US)",
volume = "48",
pages = "4030--4033",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "22",

}

TY - JOUR

T1 - Metabolie labeling of sialic acids in living animals with alkynyl sugars

AU - Chang, Pamela V.

AU - Chen, Xing

AU - Smyrniotis, Chris

AU - Xenakis, Alexander

AU - Hu, Tianshun

AU - Bertozzi, Carolyn R.

AU - Wu, Peng

PY - 2009/5/18

Y1 - 2009/5/18

N2 - Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

AB - Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl) mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

UR - http://www.scopus.com/inward/record.url?scp=66149187132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149187132&partnerID=8YFLogxK

U2 - 10.1002/anie.200806319

DO - 10.1002/anie.200806319

M3 - Article

VL - 48

SP - 4030

EP - 4033

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 22

ER -