Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation

Celestino Sardu, Giovanni Carreras, Spyridon Katsanos, Vasileios Kamperidis, Maria Caterina Pace, Maria Beatrice Passavanti, Ilaria Fava, Pasquale Paolisso, Gorizio Pieretti, Giovanni Francesco Nicoletti, Gaetano Santulli, Giuseppe Paolisso, Raffaele Marfella

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31 Scopus citations

Abstract

Background: The purpose of this study was to investigate the impact of metabolic syndrome (MS) on outcome of catheter ablation (CA) for treatment of frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT), left ventricular outflow tract (LVOT) or coronary cusps (CUSPs), in patients with normal ventricular systolic function and absence of cardiac structural disease. Methods: In this multicentre prospective study we evaluated 90 patients with frequent PVCs originating from RVOT (n = 68), LVOT (n = 19) or CUSPs (n = 3), treated with CA. According to baseline diagnosis they were divided in patients with MS (n = 24) or without MS (n = 66). The study endpoint was a composite of recurrence of acute or delayed outflow tract ventricular arrhythmia: acute spontaneous or inducible outflow tract ventricular arrhythmia recurrence or recurrence of outflow tract PVCs in holter monitoring at follow up. Results: Patients with MS compared to patients without MS showed a higher acute post-procedural recurrence of outflow tract PVCs (n = 8, 66.6%, vs. n = 6, 9.0%, p = 0.005). At a mean follow up of 35 (17-43) months survival free of recurrence of outflow tract PVCs was lower in patients with baseline MS compared to patients without MS diagnosis (log-rank test, p < 0.001). In cox regression analysis, only MS was independently associated with study endpoint (HR = 9.655, 95% CI 3.000-31.0.68 , p < 0.001). Conclusions: MS is associated with a higher recurrence rate of outflow tract PVCs after CA in patients without structural heart disease.

Original languageEnglish (US)
Article number176
JournalBMC Cardiovascular Disorders
Volume14
Issue number1
DOIs
StatePublished - Dec 6 2014
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Sardu, C., Carreras, G., Katsanos, S., Kamperidis, V., Pace, M. C., Passavanti, M. B., Fava, I., Paolisso, P., Pieretti, G., Nicoletti, G. F., Santulli, G., Paolisso, G., & Marfella, R. (2014). Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation. BMC Cardiovascular Disorders, 14(1), [176]. https://doi.org/10.1186/1471-2261-14-176