Metabolic Syndrome in Hispanic Youth: Results from the Hispanic Community Children's Health Study/Study of Latino Youth

Samantha A. Reina, Maria M. Llabre, Denise C. Vidot, Carmen R. Isasi, Krista Perreira, Mercedes Carnethon, Christina M. Parrinello, Linda C. Gallo, Guadalupe X. Ayala, Alan Delamater

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, is being diagnosed in youth. Specific diagnostic criteria used to define MetS influence prevalence estimates and populations considered at risk for cardiovascular disease. The National Cholesterol Education Program's Adult Treatment Panel III (ATP), the World Health Organization (WHO), and the International Diabetes Federation (IDF) provide three MetS definitions used in medical research. This study examined concordance among these definitions in 1137 children 10-16 years of age, who participated in the Hispanic Community Children's Health Study/Study of Latino Youth. Methods: Prevalence of MetS and of individual components was estimated using SAS. Mplus was used to test a single-factor model of MetS components (triglycerides, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, waist circumference, and fasting glucose). Results: The ATP definition identified most MetS cases in 10-15 (N = 19, 4.7%) and 16-year-old girls (N = 3, 7.3%). The IDF definition identified most cases of MetS in 10-15 (N = 16, 3.1%) and 16-year-old boys (N = 2, 2.8%). Fewest cases of MetS were identified with the WHO definition across age and sex groups. Conclusion: Only one participant was classified as having MetS across all three definitions. Confirmatory factor analysis indicated fasting glucose and systolic blood pressure did not reliably cluster with other risk factors that define MetS in Hispanic/Latino adolescents. We conclude that prevalence estimates of MetS in youth are unstable across current criteria, calling into question the accuracy of defining and diagnosing MetS in youth.

Original languageEnglish (US)
Pages (from-to)400-406
Number of pages7
JournalMetabolic Syndrome and Related Disorders
Volume15
Issue number8
DOIs
StatePublished - Oct 1 2017

Fingerprint

Hispanic Americans
Blood Pressure
Child Health
Fasting
Glucose
Waist Circumference
HDL Cholesterol
Statistical Factor Analysis
Biomedical Research
Triglycerides
Cardiovascular Diseases
Age Groups
Cholesterol
Education

Keywords

  • diagnosis
  • Hispanic/Latino
  • metabolic syndrome
  • youth

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Metabolic Syndrome in Hispanic Youth : Results from the Hispanic Community Children's Health Study/Study of Latino Youth. / Reina, Samantha A.; Llabre, Maria M.; Vidot, Denise C.; Isasi, Carmen R.; Perreira, Krista; Carnethon, Mercedes; Parrinello, Christina M.; Gallo, Linda C.; Ayala, Guadalupe X.; Delamater, Alan.

In: Metabolic Syndrome and Related Disorders, Vol. 15, No. 8, 01.10.2017, p. 400-406.

Research output: Contribution to journalArticle

Reina, SA, Llabre, MM, Vidot, DC, Isasi, CR, Perreira, K, Carnethon, M, Parrinello, CM, Gallo, LC, Ayala, GX & Delamater, A 2017, 'Metabolic Syndrome in Hispanic Youth: Results from the Hispanic Community Children's Health Study/Study of Latino Youth', Metabolic Syndrome and Related Disorders, vol. 15, no. 8, pp. 400-406. https://doi.org/10.1089/met.2017.0054
Reina, Samantha A. ; Llabre, Maria M. ; Vidot, Denise C. ; Isasi, Carmen R. ; Perreira, Krista ; Carnethon, Mercedes ; Parrinello, Christina M. ; Gallo, Linda C. ; Ayala, Guadalupe X. ; Delamater, Alan. / Metabolic Syndrome in Hispanic Youth : Results from the Hispanic Community Children's Health Study/Study of Latino Youth. In: Metabolic Syndrome and Related Disorders. 2017 ; Vol. 15, No. 8. pp. 400-406.
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abstract = "Background: Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, is being diagnosed in youth. Specific diagnostic criteria used to define MetS influence prevalence estimates and populations considered at risk for cardiovascular disease. The National Cholesterol Education Program's Adult Treatment Panel III (ATP), the World Health Organization (WHO), and the International Diabetes Federation (IDF) provide three MetS definitions used in medical research. This study examined concordance among these definitions in 1137 children 10-16 years of age, who participated in the Hispanic Community Children's Health Study/Study of Latino Youth. Methods: Prevalence of MetS and of individual components was estimated using SAS. Mplus was used to test a single-factor model of MetS components (triglycerides, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, waist circumference, and fasting glucose). Results: The ATP definition identified most MetS cases in 10-15 (N = 19, 4.7{\%}) and 16-year-old girls (N = 3, 7.3{\%}). The IDF definition identified most cases of MetS in 10-15 (N = 16, 3.1{\%}) and 16-year-old boys (N = 2, 2.8{\%}). Fewest cases of MetS were identified with the WHO definition across age and sex groups. Conclusion: Only one participant was classified as having MetS across all three definitions. Confirmatory factor analysis indicated fasting glucose and systolic blood pressure did not reliably cluster with other risk factors that define MetS in Hispanic/Latino adolescents. We conclude that prevalence estimates of MetS in youth are unstable across current criteria, calling into question the accuracy of defining and diagnosing MetS in youth.",
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AU - Perreira, Krista

AU - Carnethon, Mercedes

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N2 - Background: Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, is being diagnosed in youth. Specific diagnostic criteria used to define MetS influence prevalence estimates and populations considered at risk for cardiovascular disease. The National Cholesterol Education Program's Adult Treatment Panel III (ATP), the World Health Organization (WHO), and the International Diabetes Federation (IDF) provide three MetS definitions used in medical research. This study examined concordance among these definitions in 1137 children 10-16 years of age, who participated in the Hispanic Community Children's Health Study/Study of Latino Youth. Methods: Prevalence of MetS and of individual components was estimated using SAS. Mplus was used to test a single-factor model of MetS components (triglycerides, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, waist circumference, and fasting glucose). Results: The ATP definition identified most MetS cases in 10-15 (N = 19, 4.7%) and 16-year-old girls (N = 3, 7.3%). The IDF definition identified most cases of MetS in 10-15 (N = 16, 3.1%) and 16-year-old boys (N = 2, 2.8%). Fewest cases of MetS were identified with the WHO definition across age and sex groups. Conclusion: Only one participant was classified as having MetS across all three definitions. Confirmatory factor analysis indicated fasting glucose and systolic blood pressure did not reliably cluster with other risk factors that define MetS in Hispanic/Latino adolescents. We conclude that prevalence estimates of MetS in youth are unstable across current criteria, calling into question the accuracy of defining and diagnosing MetS in youth.

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