Metabolic syndrome and smoking are associated with future development of advanced chronic kidney disease in older adults

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Abstract

Introduction: Metabolic syndrome (MetS) and smoking have been identified as risk factors for chronic kidney disease (CKD) in cross-sectional studies in various age groups, but longitudinal data on progression of CKD in older adults are limited. Our objectives were to examine whether MetS and its components and smoking predict the onset of CKD stage 3b (CKD-3b) in older adults. Methods: A subset of participants of the Einstein Aging Study who were free of diabetes, dementia, and CKD-3b at enrollment were included in this analysis. CKD-3b was defined as an estimated glomerular filtration rate 2. Cox proportional hazards models were used in these analyses. Results: In total, 413 ≥70-year-old individuals were eligible for this study. 65.4% were female and 26.6% were black. 22.3% of the participants had MetS at baseline, 4.4% were active smokers, and 6.1% developed CKD-3b over a mean of 4 years of follow-up. MetS and smoking independently predicted incident CKD in our fully adjusted model (hazard ratio 3.65, 95% CI 1.20-10.60, p = 0.022; hazard ratio 29.69, 95% CI 4.47-197.23, p = 0.000). Conclusion: MetS and smoking are associated with an increased incidence of CKD-3b. These risk factors are modifiable, easily identified and prevented through better health care practice and early diagnosis.

Original languageEnglish (US)
Pages (from-to)108-115
Number of pages8
JournalCardioRenal Medicine
Volume6
Issue number2
DOIs
StatePublished - 2015

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Chronic Renal Insufficiency
Smoking
Proportional Hazards Models
Glomerular Filtration Rate
Dementia
Early Diagnosis
Age Groups
Cross-Sectional Studies
Delivery of Health Care
Incidence

Keywords

  • Chronic kidney disease
  • Metabolic syndrome
  • Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Urology

Cite this

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title = "Metabolic syndrome and smoking are associated with future development of advanced chronic kidney disease in older adults",
abstract = "Introduction: Metabolic syndrome (MetS) and smoking have been identified as risk factors for chronic kidney disease (CKD) in cross-sectional studies in various age groups, but longitudinal data on progression of CKD in older adults are limited. Our objectives were to examine whether MetS and its components and smoking predict the onset of CKD stage 3b (CKD-3b) in older adults. Methods: A subset of participants of the Einstein Aging Study who were free of diabetes, dementia, and CKD-3b at enrollment were included in this analysis. CKD-3b was defined as an estimated glomerular filtration rate 2. Cox proportional hazards models were used in these analyses. Results: In total, 413 ≥70-year-old individuals were eligible for this study. 65.4{\%} were female and 26.6{\%} were black. 22.3{\%} of the participants had MetS at baseline, 4.4{\%} were active smokers, and 6.1{\%} developed CKD-3b over a mean of 4 years of follow-up. MetS and smoking independently predicted incident CKD in our fully adjusted model (hazard ratio 3.65, 95{\%} CI 1.20-10.60, p = 0.022; hazard ratio 29.69, 95{\%} CI 4.47-197.23, p = 0.000). Conclusion: MetS and smoking are associated with an increased incidence of CKD-3b. These risk factors are modifiable, easily identified and prevented through better health care practice and early diagnosis.",
keywords = "Chronic kidney disease, Metabolic syndrome, Smoking",
author = "Zammit, {Andrea R.} and Katz, {Mindy Joy} and Derby, {Carol A.} and Markus Bitzer and Lipton, {Richard B.}",
year = "2015",
doi = "10.1159/000441624",
language = "English (US)",
volume = "6",
pages = "108--115",
journal = "CardioRenal Medicine",
issn = "1664-3828",
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TY - JOUR

T1 - Metabolic syndrome and smoking are associated with future development of advanced chronic kidney disease in older adults

AU - Zammit, Andrea R.

AU - Katz, Mindy Joy

AU - Derby, Carol A.

AU - Bitzer, Markus

AU - Lipton, Richard B.

PY - 2015

Y1 - 2015

N2 - Introduction: Metabolic syndrome (MetS) and smoking have been identified as risk factors for chronic kidney disease (CKD) in cross-sectional studies in various age groups, but longitudinal data on progression of CKD in older adults are limited. Our objectives were to examine whether MetS and its components and smoking predict the onset of CKD stage 3b (CKD-3b) in older adults. Methods: A subset of participants of the Einstein Aging Study who were free of diabetes, dementia, and CKD-3b at enrollment were included in this analysis. CKD-3b was defined as an estimated glomerular filtration rate 2. Cox proportional hazards models were used in these analyses. Results: In total, 413 ≥70-year-old individuals were eligible for this study. 65.4% were female and 26.6% were black. 22.3% of the participants had MetS at baseline, 4.4% were active smokers, and 6.1% developed CKD-3b over a mean of 4 years of follow-up. MetS and smoking independently predicted incident CKD in our fully adjusted model (hazard ratio 3.65, 95% CI 1.20-10.60, p = 0.022; hazard ratio 29.69, 95% CI 4.47-197.23, p = 0.000). Conclusion: MetS and smoking are associated with an increased incidence of CKD-3b. These risk factors are modifiable, easily identified and prevented through better health care practice and early diagnosis.

AB - Introduction: Metabolic syndrome (MetS) and smoking have been identified as risk factors for chronic kidney disease (CKD) in cross-sectional studies in various age groups, but longitudinal data on progression of CKD in older adults are limited. Our objectives were to examine whether MetS and its components and smoking predict the onset of CKD stage 3b (CKD-3b) in older adults. Methods: A subset of participants of the Einstein Aging Study who were free of diabetes, dementia, and CKD-3b at enrollment were included in this analysis. CKD-3b was defined as an estimated glomerular filtration rate 2. Cox proportional hazards models were used in these analyses. Results: In total, 413 ≥70-year-old individuals were eligible for this study. 65.4% were female and 26.6% were black. 22.3% of the participants had MetS at baseline, 4.4% were active smokers, and 6.1% developed CKD-3b over a mean of 4 years of follow-up. MetS and smoking independently predicted incident CKD in our fully adjusted model (hazard ratio 3.65, 95% CI 1.20-10.60, p = 0.022; hazard ratio 29.69, 95% CI 4.47-197.23, p = 0.000). Conclusion: MetS and smoking are associated with an increased incidence of CKD-3b. These risk factors are modifiable, easily identified and prevented through better health care practice and early diagnosis.

KW - Chronic kidney disease

KW - Metabolic syndrome

KW - Smoking

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