TY - JOUR
T1 - Metabolic syndrome and risk of endometrial cancer in postmenopausal women
T2 - a prospective study
AU - Arthur, Rhonda S.
AU - Kabat, Geoffrey C.
AU - Kim, Mimi Y.
AU - Wild, Robert A.
AU - Shadyab, Aladdin H.
AU - Wactawski-Wende, Jean
AU - Ho, Gloria Y.F.
AU - Reeves, Katherine W.
AU - Kuller, Lewis H.
AU - Luo, Juhua
AU - Beebe-Dimmer, Jennifer
AU - Simon, Michael S.
AU - Strickler, Howard
AU - Wassertheil-Smoller, Sylvia
AU - Rohan, Thomas E.
N1 - Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2019/4/15
Y1 - 2019/4/15
N2 - Background: Obesity is a strong risk factor for endometrial cancer, but it is unclear whether metabolic syndrome (MetS) contributes to endometrial cancer risk over and above the contribution of obesity. Methods: We examined the association of MetS and its components with risk of endometrial cancer in a sub-cohort of 24,210 women enrolled in the Women’s Health Initiative cohort study. Two variants of the National Cholesterol Education Program Adult Treatment Panel III definition of the MetS were used: one including and one excluding waist circumference (WC). Cox proportional hazards models were used to estimate the association of the study exposures with disease risk. Results: When WC was included in the definition, MetS showed an approximately two-fold increase in endometrial cancer risk (HR 2.20; 95% CI 1.61–3.02); however, when WC was excluded, MetS was no longer associated with risk. We also observed that women with hyperglycemia, dyslipidemia and hypertension, in combination, had almost a twofold increased risk of endometrial cancer, independent of WC (HR 1.94; 95% CI 1.09, 3.46). Glucose, and, in particular, WC and body mass index were also positively associated with risk. Conclusions: Our findings suggest that MetS may predict risk of endometrial cancer independent of obesity among women with the remaining four Mets components.
AB - Background: Obesity is a strong risk factor for endometrial cancer, but it is unclear whether metabolic syndrome (MetS) contributes to endometrial cancer risk over and above the contribution of obesity. Methods: We examined the association of MetS and its components with risk of endometrial cancer in a sub-cohort of 24,210 women enrolled in the Women’s Health Initiative cohort study. Two variants of the National Cholesterol Education Program Adult Treatment Panel III definition of the MetS were used: one including and one excluding waist circumference (WC). Cox proportional hazards models were used to estimate the association of the study exposures with disease risk. Results: When WC was included in the definition, MetS showed an approximately two-fold increase in endometrial cancer risk (HR 2.20; 95% CI 1.61–3.02); however, when WC was excluded, MetS was no longer associated with risk. We also observed that women with hyperglycemia, dyslipidemia and hypertension, in combination, had almost a twofold increased risk of endometrial cancer, independent of WC (HR 1.94; 95% CI 1.09, 3.46). Glucose, and, in particular, WC and body mass index were also positively associated with risk. Conclusions: Our findings suggest that MetS may predict risk of endometrial cancer independent of obesity among women with the remaining four Mets components.
KW - Abdominal adiposity
KW - Endometrial cancer
KW - Metabolic syndrome
KW - Obesity
KW - Postmenopausal women
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U2 - 10.1007/s10552-019-01139-5
DO - 10.1007/s10552-019-01139-5
M3 - Article
C2 - 30788634
AN - SCOPUS:85061925576
SN - 0957-5243
VL - 30
SP - 355
EP - 363
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 4
ER -
