Metabolic syndrome and inflammatory biomarkers

A community-based cross-sectional study at the Framingham Heart Study

Dhayana Dallmeier, Martin G. Larson, Ramachandran S. Vasan, John F. Keaney, Joao Daniel T. Fontes, James B. Meigs, Caroline S. Fox, Emelia J. Benjamin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Prior studies reported conflicting findings on the association between metabolic syndrome and inflammatory biomarkers. We tested the cross-sectional associations between metabolic syndrome and nine inflammatory markers. Methods. We measured C-reactive protein, CD40 ligand, interleukin-6, intercellular adhesion molecule-1, monocyte chemoattractant protein-1, osteoprotegerin, P-selectin, tumor necrosis factor-alpha, and tumor necrosis factor receptor-2 in 2570 Framingham Offspring Study participants free of diabetes and cardiovascular disease at examination 7. Metabolic syndrome was defined by National Cholesterol Education Program criteria. We performed multivariable linear regressions for each biomarker with metabolic syndrome as the exposure adjusting for age, sex, smoking, aspirin use, and hormone replacement. We subsequently added to the models components of the metabolic syndrome as continuous traits plus lipid lowering and hypertension treatments. We considered P < 0.05 as statistically significant. Results: Metabolic syndrome was present in 984 (38%) participants and was statistically significantly associated with each biomarker (all P < 0.02) except osteoprotegerin. After adjusting for its component variables, the metabolic syndrome was associated only with P-selectin (1.06 fold higher in metabolic syndrome, 95% CI 1.02, 1.10, p = 0.005). Conclusions: Metabolic syndrome was associated with multiple inflammatory biomarkers. However, adjusting for each of its components eliminated the association with most inflammatory markers, except P-selectin. Our results suggest that the relation between metabolic syndrome and inflammation is largely accounted for by its components.

Original languageEnglish (US)
Article number28
JournalDiabetology and Metabolic Syndrome
Volume4
Issue number1
DOIs
StatePublished - 2012
Externally publishedYes

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Cross-Sectional Studies
Biomarkers
P-Selectin
Osteoprotegerin
Receptors, Tumor Necrosis Factor, Type II
CD40 Ligand
Chemokine CCL2
Intercellular Adhesion Molecule-1
C-Reactive Protein
Aspirin
Linear Models
Interleukin-6
Cardiovascular Diseases
Tumor Necrosis Factor-alpha
Smoking
Cholesterol
Hormones
Hypertension
Inflammation
Lipids

Keywords

  • Body mass index
  • Inflammatory biomarkers
  • Insulin resistance
  • Metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Metabolic syndrome and inflammatory biomarkers : A community-based cross-sectional study at the Framingham Heart Study. / Dallmeier, Dhayana; Larson, Martin G.; Vasan, Ramachandran S.; Keaney, John F.; Fontes, Joao Daniel T.; Meigs, James B.; Fox, Caroline S.; Benjamin, Emelia J.

In: Diabetology and Metabolic Syndrome, Vol. 4, No. 1, 28, 2012.

Research output: Contribution to journalArticle

Dallmeier, Dhayana ; Larson, Martin G. ; Vasan, Ramachandran S. ; Keaney, John F. ; Fontes, Joao Daniel T. ; Meigs, James B. ; Fox, Caroline S. ; Benjamin, Emelia J. / Metabolic syndrome and inflammatory biomarkers : A community-based cross-sectional study at the Framingham Heart Study. In: Diabetology and Metabolic Syndrome. 2012 ; Vol. 4, No. 1.
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