Metabolic requirements for the maintenance of self-renewing stem cells

Keisuke Ito, Toshio Suda

Research output: Contribution to journalReview article

444 Scopus citations

Abstract

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency. Studies of genetically-engineered mouse models and recent advances in metabolomic analysis, particularly in haematopoietic stem cells, have deepened our understanding of the contribution made by metabolic cues to the regulation of stem cell self-renewal. Many types of stem cells heavily rely on anaerobic glycolysis, and stem cell function is also regulated by bioenergetic signalling, the AKT-mTOR pathway, Gln metabolism and fatty acid metabolism. As maintenance of a stem cell pool requires a finely-tuned balance between self-renewal and differentiation, investigations into the molecular mechanisms and metabolic pathways underlying these decisions hold great therapeutic promise.

Original languageEnglish (US)
Pages (from-to)243-256
Number of pages14
JournalNature Reviews Molecular Cell Biology
Volume15
Issue number4
DOIs
StatePublished - Apr 2014

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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