Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'

Yunping Qiu; Minjun Chen; Mingming Su; Guoxiang Xie; Xin Li; Mingmei Zhou; Aihua Zhao; Jian Jiang; Wei Jia

doi:10.1186/1749-8546-3-3

Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'

Yunping Qiu, Minjun Chen, Mingming Su, Guoxiang Xie, Xin Li, Mingmei Zhou, Aihua Zhao, Jian Jiang, Wei Jia

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear. Methods: Using GC-MS-based metabolic profiling, we investigated the metabolic responses to Herba Cistanches intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'. Results: The metabolic profiles of the rats after hydrocortisone injection deviated from the pre-dose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of Herba Cistanches returned to the pre-dose state on day 10. Conclusion: The intervention of Herba Cistanches caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.

Original language	English (US)
Article number	3
Journal	Chinese Medicine
Volume	3
DOIs	https://doi.org/10.1186/1749-8546-3-3
State	Published - Mar 10 2008
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Complementary and alternative medicine

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title = "Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'",

abstract = "Background: Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear. Methods: Using GC-MS-based metabolic profiling, we investigated the metabolic responses to Herba Cistanches intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'. Results: The metabolic profiles of the rats after hydrocortisone injection deviated from the pre-dose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of Herba Cistanches returned to the pre-dose state on day 10. Conclusion: The intervention of Herba Cistanches caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.",

author = "Yunping Qiu and Minjun Chen and Mingming Su and Guoxiang Xie and Xin Li and Mingmei Zhou and Aihua Zhao and Jian Jiang and Wei Jia",

note = "Funding Information: The authors wish to thank Yumin Liu, Jingjing Gu, Yuan He and Congying Guo for their assistance with the GC-MS analysis and animal experiments. This study was financially supported by the Young Faculty Grant from Shanghai Jiao Tong University (No. A2816A), Shanghai Leading Academic Discipline Project (No. T0301) and the National Natural Science Fund (No. 30572286).",

year = "2008",

month = mar,

day = "10",

doi = "10.1186/1749-8546-3-3",

language = "English (US)",

volume = "3",

journal = "Chinese Medicine",

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T1 - Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'

AU - Qiu, Yunping

AU - Chen, Minjun

AU - Su, Mingming

AU - Xie, Guoxiang

AU - Li, Xin

AU - Zhou, Mingmei

AU - Zhao, Aihua

AU - Jiang, Jian

AU - Jia, Wei

N1 - Funding Information: The authors wish to thank Yumin Liu, Jingjing Gu, Yuan He and Congying Guo for their assistance with the GC-MS analysis and animal experiments. This study was financially supported by the Young Faculty Grant from Shanghai Jiao Tong University (No. A2816A), Shanghai Leading Academic Discipline Project (No. T0301) and the National Natural Science Fund (No. 30572286).

PY - 2008/3/10

Y1 - 2008/3/10

N2 - Background: Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear. Methods: Using GC-MS-based metabolic profiling, we investigated the metabolic responses to Herba Cistanches intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'. Results: The metabolic profiles of the rats after hydrocortisone injection deviated from the pre-dose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of Herba Cistanches returned to the pre-dose state on day 10. Conclusion: The intervention of Herba Cistanches caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.

AB - Background: Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear. Methods: Using GC-MS-based metabolic profiling, we investigated the metabolic responses to Herba Cistanches intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'. Results: The metabolic profiles of the rats after hydrocortisone injection deviated from the pre-dose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of Herba Cistanches returned to the pre-dose state on day 10. Conclusion: The intervention of Herba Cistanches caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.

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Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'

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