Metabolic profiling reveals therapeutic effects of Herba Cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'

Yunping Qiu, Minjun Chen, Mingming Su, Guoxiang Xie, Xin Li, Mingmei Zhou, Aihua Zhao, Jian Jiang, Wei Jia

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background: Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear. Methods: Using GC-MS-based metabolic profiling, we investigated the metabolic responses to Herba Cistanches intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'. Results: The metabolic profiles of the rats after hydrocortisone injection deviated from the pre-dose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of Herba Cistanches returned to the pre-dose state on day 10. Conclusion: The intervention of Herba Cistanches caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.

Original languageEnglish (US)
Article number3
JournalChinese Medicine
Volume3
DOIs
StatePublished - Mar 10 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Complementary and alternative medicine

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