Metabolic acidosis and the progression of chronic kidney disease

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56 Scopus citations


Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the treatment of acidosis with oral alkali can slow the progression of kidney disease.

Original languageEnglish (US)
Article number55
JournalBMC Nephrology
Issue number1
StatePublished - Apr 3 2014


  • Aldosterone
  • Alkali
  • Ammonia
  • Bicarbonate
  • Complement
  • Dietary acid
  • Endothelin
  • Net endogenous acid production
  • Sodium bicarbonate

ASJC Scopus subject areas

  • Nephrology


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