Metabolic acidosis and the progression of chronic kidney disease

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the treatment of acidosis with oral alkali can slow the progression of kidney disease.

Original languageEnglish (US)
Article number55
JournalBMC Nephrology
Volume15
Issue number1
DOIs
StatePublished - Apr 3 2014

Fingerprint

Acidosis
Chronic Renal Insufficiency
Kidney Diseases
Alkalies
Disease Progression
Acids

Keywords

  • Aldosterone
  • Alkali
  • Ammonia
  • Bicarbonate
  • Complement
  • Dietary acid
  • Endothelin
  • Net endogenous acid production
  • Sodium bicarbonate

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

Metabolic acidosis and the progression of chronic kidney disease. / Chen, Wei; Abramowitz, Matthew K.

In: BMC Nephrology, Vol. 15, No. 1, 55, 03.04.2014.

Research output: Contribution to journalArticle

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