Meta-analysis of long-term outcomes of percutaneous coronary intervention or coronary artery bypass graft surgery in coronary artery disease patients with multi-vessel and/or left main stem disease

Tongwen Sun, Youdong Wan, Ziqi Liu, Shuguang Zhang, Fangxia Guan, Rui Yao, Li Zhang, Ling Li, Jinying Zhang, Quancheng Kan

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the long-term outcomes of coronary artery disease patients with left main stem and/or multi-vessel disease receiving percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG).

Methods: PubMed, EM Base, Cochrane central register of controlled trials were searched to identify randomized controlled trials concerning the long-term outcomes of PCI and CABG in coronary artery disease patients with left main stem and/or multi-vessel disease before May 2013. Keywords included "angioplasty", "coronary", "coronary artery bypass surgery" and "stent". The data were analyzed by ST ATA 12.0.

Results: Six randomized controlled trials (5 071 patients) were enrolled for analyses. Five years all-cause mortality (RR = 1.13, 95% CI-.0. 88-1. 44, P =0. 35), incidence of myocardial infarction (RR= 1.20, 95%CI:0. 69-2. 07, P = 0. 53), and angina (RR = 1. 17,95% CI:0. 88-1. 57, P=0. 28) were similar between PCI and CABG groups. Major adverse cardiac and cerebrovascular event (RR = 1. 85, 95% CI-. 1. 38-2. 48, P < 0. 01) and repeat revascularization (RR = 3. 48, 95% CI: 2. 20-5. 53, P < 0. 01) were significantly higher in PCI compared to CABG.

Conclusions: The present analysis suggests that 5 years all-cause mortality is similar between PCI and CABG strategies. However, PCI is associated with higher major adverse cardiac and cerebrovascular event and repeat revascularization rate compared to CABG in patients with unprotected left main stem and/or multi-vessel disease.

Original languageEnglish (US)
Pages (from-to)693-698
Number of pages6
JournalChinese Journal of Cardiology
Volume42
Issue number8
DOIs
StatePublished - Aug 24 2014
Externally publishedYes

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Percutaneous Coronary Intervention
Coronary Artery Bypass
Meta-Analysis
Coronary Artery Disease
Transplants
Randomized Controlled Trials
Mortality
Angioplasty
PubMed
Stents
Myocardial Infarction
Incidence

Keywords

  • Angioplasty transluminal percutaneous coronary
  • Cardiac surgical procedures
  • Meta-analysis

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Meta-analysis of long-term outcomes of percutaneous coronary intervention or coronary artery bypass graft surgery in coronary artery disease patients with multi-vessel and/or left main stem disease. / Sun, Tongwen; Wan, Youdong; Liu, Ziqi; Zhang, Shuguang; Guan, Fangxia; Yao, Rui; Zhang, Li; Li, Ling; Zhang, Jinying; Kan, Quancheng.

In: Chinese Journal of Cardiology, Vol. 42, No. 8, 24.08.2014, p. 693-698.

Research output: Contribution to journalArticle

Sun, Tongwen ; Wan, Youdong ; Liu, Ziqi ; Zhang, Shuguang ; Guan, Fangxia ; Yao, Rui ; Zhang, Li ; Li, Ling ; Zhang, Jinying ; Kan, Quancheng. / Meta-analysis of long-term outcomes of percutaneous coronary intervention or coronary artery bypass graft surgery in coronary artery disease patients with multi-vessel and/or left main stem disease. In: Chinese Journal of Cardiology. 2014 ; Vol. 42, No. 8. pp. 693-698.
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T1 - Meta-analysis of long-term outcomes of percutaneous coronary intervention or coronary artery bypass graft surgery in coronary artery disease patients with multi-vessel and/or left main stem disease

AU - Sun, Tongwen

AU - Wan, Youdong

AU - Liu, Ziqi

AU - Zhang, Shuguang

AU - Guan, Fangxia

AU - Yao, Rui

AU - Zhang, Li

AU - Li, Ling

AU - Zhang, Jinying

AU - Kan, Quancheng

PY - 2014/8/24

Y1 - 2014/8/24

N2 - Objective: To evaluate the long-term outcomes of coronary artery disease patients with left main stem and/or multi-vessel disease receiving percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG).Methods: PubMed, EM Base, Cochrane central register of controlled trials were searched to identify randomized controlled trials concerning the long-term outcomes of PCI and CABG in coronary artery disease patients with left main stem and/or multi-vessel disease before May 2013. Keywords included "angioplasty", "coronary", "coronary artery bypass surgery" and "stent". The data were analyzed by ST ATA 12.0.Results: Six randomized controlled trials (5 071 patients) were enrolled for analyses. Five years all-cause mortality (RR = 1.13, 95% CI-.0. 88-1. 44, P =0. 35), incidence of myocardial infarction (RR= 1.20, 95%CI:0. 69-2. 07, P = 0. 53), and angina (RR = 1. 17,95% CI:0. 88-1. 57, P=0. 28) were similar between PCI and CABG groups. Major adverse cardiac and cerebrovascular event (RR = 1. 85, 95% CI-. 1. 38-2. 48, P < 0. 01) and repeat revascularization (RR = 3. 48, 95% CI: 2. 20-5. 53, P < 0. 01) were significantly higher in PCI compared to CABG.Conclusions: The present analysis suggests that 5 years all-cause mortality is similar between PCI and CABG strategies. However, PCI is associated with higher major adverse cardiac and cerebrovascular event and repeat revascularization rate compared to CABG in patients with unprotected left main stem and/or multi-vessel disease.

AB - Objective: To evaluate the long-term outcomes of coronary artery disease patients with left main stem and/or multi-vessel disease receiving percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG).Methods: PubMed, EM Base, Cochrane central register of controlled trials were searched to identify randomized controlled trials concerning the long-term outcomes of PCI and CABG in coronary artery disease patients with left main stem and/or multi-vessel disease before May 2013. Keywords included "angioplasty", "coronary", "coronary artery bypass surgery" and "stent". The data were analyzed by ST ATA 12.0.Results: Six randomized controlled trials (5 071 patients) were enrolled for analyses. Five years all-cause mortality (RR = 1.13, 95% CI-.0. 88-1. 44, P =0. 35), incidence of myocardial infarction (RR= 1.20, 95%CI:0. 69-2. 07, P = 0. 53), and angina (RR = 1. 17,95% CI:0. 88-1. 57, P=0. 28) were similar between PCI and CABG groups. Major adverse cardiac and cerebrovascular event (RR = 1. 85, 95% CI-. 1. 38-2. 48, P < 0. 01) and repeat revascularization (RR = 3. 48, 95% CI: 2. 20-5. 53, P < 0. 01) were significantly higher in PCI compared to CABG.Conclusions: The present analysis suggests that 5 years all-cause mortality is similar between PCI and CABG strategies. However, PCI is associated with higher major adverse cardiac and cerebrovascular event and repeat revascularization rate compared to CABG in patients with unprotected left main stem and/or multi-vessel disease.

KW - Angioplasty transluminal percutaneous coronary

KW - Cardiac surgical procedures

KW - Meta-analysis

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