Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Meian He, Min Xu, Ben Zhang, Jun Liang, Peng Chen, Jong Young Lee, Todd A. Johnson, Huaixing Li, Xiaobo Yang, Juncheng Dai, Liming Liang, Lixuan Gui, Qibin Qi, Jinyan Huang, Yanping Li, Linda S. Adair, Tin Aung, Qiuyin Cai, Ching Yu Cheng, Myeong Chan ChoYoon Shin Cho, Minjie Chu, Bin Cui, Yu Tang Gao, Min Jin Go, Dongfeng Gu, Weiqiong Gu, Huan Guo, Yongchen Hao, Jie Hong, Zhibin Hu, Yanling Hu, Jianfeng Huang, Joo Yeon Hwang, Mohammad Kamran Ikram, Guangfu Jin, Dae Hee Kang, Chiea Chuen Khor, Bong Jo Kim, Hung Tae Kim, Michiaki Kubo, Jeannette Lee, Juyoung Lee, Nanette R. Lee, Ruoying Li, Jun Li, Jian Jun Liu, Jirong Longe, Wei Lu, Xiangfeng Lu, Xiaoping Miao, Yukinori Okada, Rick Twee Hee Ong, Gaokun Qiu, Mark Seielstad, Xueling Sim, Huaidong Song, Fumihiko Takeuchi, Toshihiro Tanaka, Phil R. Taylor, Laiyuan Wang, Weiqing Wang, Yiqin Wang, Chen Wu, Ying Wu, Yong Bing Xiang, Ken Yamamoto, Handong Yang, Ming Liao, Mitsuhiro Yokota, Terri Young, Xiaomin Zhang, Norihiro Kato, Qing K. Wang, Wei Zheng, Frank B. Hu, Dongxin Lin, Hongbing Shen, Yik Ying Teo, Zengnan Mo, Tien Yin Wong, Xu Lin, Karen L. Mohlke, Guang Ning, Tatsuhiko Tsunoda, Bok Ghee Han, Xiao Ou Shu, E. Shyong Tai, Tangchun Wu, Lu Qi

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10-8, together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.

Original languageEnglish (US)
Pages (from-to)1791-1800
Number of pages10
JournalHuman molecular genetics
Volume24
Issue number6
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    He, M., Xu, M., Zhang, B., Liang, J., Chen, P., Lee, J. Y., Johnson, T. A., Li, H., Yang, X., Dai, J., Liang, L., Gui, L., Qi, Q., Huang, J., Li, Y., Adair, L. S., Aung, T., Cai, Q., Cheng, C. Y., ... Qi, L. (2015). Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Human molecular genetics, 24(6), 1791-1800. https://doi.org/10.1093/hmg/ddu583