Abstract
This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson’s disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk-positive patches in routinely prepared formalin-fixed paraffin-embedded striatal tissues. In comparison with normal controls, MEnk-positive patches and pallidal MEnk-positive axon terminals were strongly present in patients with PD, showing characteristic distribution patterns. By comparison, in SND patients, there was striking diminution of MEnk staining in the putamen and ventrolateral portion of the GPe, while MEnk patches were persistent in the caudate nucleus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1051-1056 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 40 |
| Issue number | 7 |
| State | Published - 1990 |
Fingerprint
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology
- Neuroscience(all)
Cite this
Met-enkephalin immunoreactivity in the basal ganglia in parkinson’s disease and striatonigral degeneration. / Goto, Satoshi; Hirano, Asao; Matsumoto, Sadayuki.
In: Neurology, Vol. 40, No. 7, 1990, p. 1051-1056.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Met-enkephalin immunoreactivity in the basal ganglia in parkinson’s disease and striatonigral degeneration
AU - Goto, Satoshi
AU - Hirano, Asao
AU - Matsumoto, Sadayuki
PY - 1990
Y1 - 1990
N2 - This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson’s disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk-positive patches in routinely prepared formalin-fixed paraffin-embedded striatal tissues. In comparison with normal controls, MEnk-positive patches and pallidal MEnk-positive axon terminals were strongly present in patients with PD, showing characteristic distribution patterns. By comparison, in SND patients, there was striking diminution of MEnk staining in the putamen and ventrolateral portion of the GPe, while MEnk patches were persistent in the caudate nucleus.
AB - This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson’s disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk-positive patches in routinely prepared formalin-fixed paraffin-embedded striatal tissues. In comparison with normal controls, MEnk-positive patches and pallidal MEnk-positive axon terminals were strongly present in patients with PD, showing characteristic distribution patterns. By comparison, in SND patients, there was striking diminution of MEnk staining in the putamen and ventrolateral portion of the GPe, while MEnk patches were persistent in the caudate nucleus.
UR - http://www.scopus.com/inward/record.url?scp=0025293675&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025293675&partnerID=8YFLogxK
M3 - Article
C2 - 2192300
AN - SCOPUS:0025293675
VL - 40
SP - 1051
EP - 1056
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 7
ER -