Mesenchymal Stromal Cells as Cell-Based Therapeutics for Wound Healing

Samir Malhotra, Michael S. Hu, Clement D. Marshall, Tripp Leavitt, Alexander T.M. Cheung, Jennifer G. Gonzalez, Harleen Kaur, H. Peter Lorenz, Michael T. Longaker

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Chronic wounds are a source of substantial morbidity for patients and are a major financial burden for the healthcare system. There are no current therapies that reliably improve nonhealing wounds or reverse pathological scarring. Mesenchymal stromal cells (MSCs) are a promising source of novel cell-based therapies due to the ease of their harvest and their integral role in the native wound repair process. Recent work has addressed the problems of loss of plasticity and off-target delivery through use of modern bioengineering techniques. Here we describe the applications of MSCs harvested from different sources to the wound healing process and recent advances in delivery of MSCs to targeted sites of injury.

Original languageEnglish (US)
Article number4157934
JournalStem Cells International
Volume2016
DOIs
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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