Mesenchymal stem cell: Keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine

Paul S. Frenette, Sandra I. Pinho, Daniel Lucas, Christoph Scheiermann

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their specific contributions to these various beneficial effects have remained enigmatic. In this article, we examine the definition of MSCs and discuss the importance of rigorously characterizing their stem cell activity. We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications.

Original languageEnglish (US)
Pages (from-to)285-316
Number of pages32
JournalAnnual Review of Immunology
Volume31
DOIs
StatePublished - Mar 2013

Fingerprint

Stem Cell Niche
Regenerative Medicine
Hematopoietic Stem Cells
Mesenchymal Stromal Cells
Bone Marrow
Stromal Cells
Stem Cells
Tissue Preservation
Adipocytes
Cartilage
Anti-Inflammatory Agents
Bone and Bones

Keywords

  • Cell therapy
  • Progenitor cells
  • Self-renewal

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Mesenchymal stem cell : Keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine. / Frenette, Paul S.; Pinho, Sandra I.; Lucas, Daniel; Scheiermann, Christoph.

In: Annual Review of Immunology, Vol. 31, 03.2013, p. 285-316.

Research output: Contribution to journalArticle

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