Mercury and selenium - a review on aspects related to the health of human populations in the Amazon

Maria da Conceição Nascimento, José Luiz Martins Do Nascimento, Luiz Carlos de Lima Silveira, Joao Batista Teixeira Da Rocha, Michael Aschner

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Mercury (Hg) toxicity is governed by cellular thiol compounds and its capacity to generate reactive oxygen radicals and oxidative stress. Selenium (Se) plays a key role in the prevention of the toxic effects of Hg by modulating the activity of several Se-dependent enzymes, including glutathione peroxidase (GSH-Px). In addition, dietary Se can reduce Hg toxicity by directly interacting with either Hg(II) or methylmercury (MeHg) to form inert products, such as HgSe complexes. Although experimental and environmental data have indicated a protective role for selenium against Hg toxicity, human data are more limited and somewhat controversial. In the Amazon Region of Brazil, Hg pollution is rampant as a result of gold (Au) mining and other anthropogenic factors, leading to the pervasive release of large quantities of metallic Hg0 into the environment. Exposure to Hg in this region is associated with direct occupational exposure in the gold mining industry, as well as consumption by inhabitants of riverside communities of a diet rich in MeHg-contaminated fish. Human exposure to MeHg in the Amazon through the diet has been monitored by measuring Hg and MeHg in hair samples. In this paper, we review the environmental contamination of Hg in the Amazon and detail human exposures in populations of this region. We conclude with a brief synopsis on Se levels in the Amazon population and provide a brief review of data available on the interaction between Hg and Se in this region. Overall, the literature supports the notion that low environmental Se is linked to susceptibility to Hg toxicity and that Se levels could be used as a bioindicator to monitor the health of Hg-exposed subjects. However, in light of the limited human data on this subject, further epidemiological studies are needed to clarify how changes in Se levels modify the toxicity of environmental Hg.

Original languageEnglish (US)
Pages (from-to)222-245
Number of pages24
JournalEnvironmental Bioindicators
Volume4
Issue number3
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Amazon
  • Exposure
  • Mercury
  • Methylmercury
  • Selenium
  • Tapajós river basin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

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    da Conceição Nascimento, M., Nascimento, J. L. M. D., de Lima Silveira, L. C., Da Rocha, J. B. T., & Aschner, M. (2009). Mercury and selenium - a review on aspects related to the health of human populations in the Amazon. Environmental Bioindicators, 4(3), 222-245. https://doi.org/10.1080/15555270903143440