TY - CHAP
T1 - Mercury
AU - Ni, Mingwei
AU - Li, Xin
AU - dos Santos, Ana Paula Marreilha
AU - Farina, Marcelo
AU - da Rocha, João Batista Teixeira
AU - Avila, Daiana S.
AU - Soldin, Offie P.
AU - Rongzhu, Lu
AU - Milatovic, Dejan
AU - Aschner, Michael
N1 - Publisher Copyright:
© 2017 Elsevier Inc. All rights reserved.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Methylmercury (MeHg), an organomercurial, is one of the most prevalent and toxic environmental pollutants. The major route of human exposure occurs via consumption of MeHg-adulterated seafood. Historically, MeHg epidemics in Minamata Bay, Japan, and in Iraq provided evidence of its developmental toxicity and neurological damage. This chapter describes MeHg kinetics in the human body and focuses predominantly on mechanisms involved in neuropathological and reproductive effects. The chapter also discusses the differential susceptibility to MeHg in fetuses and adults, with a special emphasis on its aberrant effects in the developing central nervous system. Discussions on risk assessment, treatment, and future directions are also covered in this chapter.
AB - Methylmercury (MeHg), an organomercurial, is one of the most prevalent and toxic environmental pollutants. The major route of human exposure occurs via consumption of MeHg-adulterated seafood. Historically, MeHg epidemics in Minamata Bay, Japan, and in Iraq provided evidence of its developmental toxicity and neurological damage. This chapter describes MeHg kinetics in the human body and focuses predominantly on mechanisms involved in neuropathological and reproductive effects. The chapter also discusses the differential susceptibility to MeHg in fetuses and adults, with a special emphasis on its aberrant effects in the developing central nervous system. Discussions on risk assessment, treatment, and future directions are also covered in this chapter.
KW - Developmental toxicity
KW - Mercury
KW - Reproductive toxicity
UR - http://www.scopus.com/inward/record.url?scp=85046857639&partnerID=8YFLogxK
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U2 - 10.1016/B978-0-12-804239-7.00033-0
DO - 10.1016/B978-0-12-804239-7.00033-0
M3 - Chapter
AN - SCOPUS:85046857639
SP - 583
EP - 594
BT - Reproductive and Developmental Toxicology
PB - Elsevier
ER -