Menopause and risk of diabetes in the Diabetes Prevention Program

Catherine Kim, Sharon L. Edelstein, Jill P. Crandall, Dana Dabelea, Abbas E. Kitabchi, Richard F. Hamman, Maria G. Montez, Leigh Perreault, Mary A. Foulkes, Elizabeth Barrett-Connor

Research output: Contribution to journalArticle

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Abstract

Objective: The study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions. Methods: The study population included women in premenopause (n = 708), women in natural postmenopause (n = 328), and women with bilateral oophorectomy (n = 201) in the Diabetes Prevention Program, a randomized placebo-controlled trial of lifestyle intervention and metformin among glucose-intolerant adults. Associations between menopause and diabetes risk were evaluated using Cox proportional hazard models that adjusted for demographic variables (age, race/ethnicity, family history of diabetes, history of gestational diabetes mellitus), waist circumference, insulin resistance, and corrected insulin response. Similar models were constructed after stratification by menopause type and hormone therapy use. Results: After adjustment for age, there was no association between natural menopause or bilateral oophorectomy and diabetes risk. Differences by study arm were observed in women who reported bilateral oophorectomy. In the lifestyle arm, women with bilateral oophorectomy had a lower adjusted hazard for diabetes (hazard ratio [HR], 0.19; 95% CI, 0.04-0.94), although observations were too few to determine if this was independent of hormone therapy use. No significant differences were seen in the metformin (HR, 1.29; 95% CI, 0.63-2.64) or placebo arms (HR, 1.37; 95% CI, 0.74-2.55). Conclusions: Among women at high risk for diabetes, natural menopause was not associated with diabetes risk and did not affect response to diabetes prevention interventions. In the lifestyle intervention, bilateral oophorectomy was associated with a decreased diabetes risk.

Original languageEnglish (US)
Pages (from-to)857-868
Number of pages12
JournalMenopause
Volume18
Issue number8
DOIs
StatePublished - Aug 2011

Fingerprint

Menopause
Ovariectomy
Life Style
Metformin
Premenopause
Placebos
Hormones
Postmenopause
Glucose Intolerance
Gestational Diabetes
Waist Circumference
Proportional Hazards Models
Insulin Resistance
Randomized Controlled Trials
Demography
Insulin
Glucose
Therapeutics
Population

Keywords

  • Impaired glucose tolerance
  • Menopause
  • Oophorectomy
  • Women
  • Words: Diabetes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Kim, C., Edelstein, S. L., Crandall, J. P., Dabelea, D., Kitabchi, A. E., Hamman, R. F., ... Barrett-Connor, E. (2011). Menopause and risk of diabetes in the Diabetes Prevention Program. Menopause, 18(8), 857-868. https://doi.org/10.1097/gme.0b013e31820f62d0

Menopause and risk of diabetes in the Diabetes Prevention Program. / Kim, Catherine; Edelstein, Sharon L.; Crandall, Jill P.; Dabelea, Dana; Kitabchi, Abbas E.; Hamman, Richard F.; Montez, Maria G.; Perreault, Leigh; Foulkes, Mary A.; Barrett-Connor, Elizabeth.

In: Menopause, Vol. 18, No. 8, 08.2011, p. 857-868.

Research output: Contribution to journalArticle

Kim, C, Edelstein, SL, Crandall, JP, Dabelea, D, Kitabchi, AE, Hamman, RF, Montez, MG, Perreault, L, Foulkes, MA & Barrett-Connor, E 2011, 'Menopause and risk of diabetes in the Diabetes Prevention Program', Menopause, vol. 18, no. 8, pp. 857-868. https://doi.org/10.1097/gme.0b013e31820f62d0
Kim C, Edelstein SL, Crandall JP, Dabelea D, Kitabchi AE, Hamman RF et al. Menopause and risk of diabetes in the Diabetes Prevention Program. Menopause. 2011 Aug;18(8):857-868. https://doi.org/10.1097/gme.0b013e31820f62d0
Kim, Catherine ; Edelstein, Sharon L. ; Crandall, Jill P. ; Dabelea, Dana ; Kitabchi, Abbas E. ; Hamman, Richard F. ; Montez, Maria G. ; Perreault, Leigh ; Foulkes, Mary A. ; Barrett-Connor, Elizabeth. / Menopause and risk of diabetes in the Diabetes Prevention Program. In: Menopause. 2011 ; Vol. 18, No. 8. pp. 857-868.
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abstract = "Objective: The study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions. Methods: The study population included women in premenopause (n = 708), women in natural postmenopause (n = 328), and women with bilateral oophorectomy (n = 201) in the Diabetes Prevention Program, a randomized placebo-controlled trial of lifestyle intervention and metformin among glucose-intolerant adults. Associations between menopause and diabetes risk were evaluated using Cox proportional hazard models that adjusted for demographic variables (age, race/ethnicity, family history of diabetes, history of gestational diabetes mellitus), waist circumference, insulin resistance, and corrected insulin response. Similar models were constructed after stratification by menopause type and hormone therapy use. Results: After adjustment for age, there was no association between natural menopause or bilateral oophorectomy and diabetes risk. Differences by study arm were observed in women who reported bilateral oophorectomy. In the lifestyle arm, women with bilateral oophorectomy had a lower adjusted hazard for diabetes (hazard ratio [HR], 0.19; 95{\%} CI, 0.04-0.94), although observations were too few to determine if this was independent of hormone therapy use. No significant differences were seen in the metformin (HR, 1.29; 95{\%} CI, 0.63-2.64) or placebo arms (HR, 1.37; 95{\%} CI, 0.74-2.55). Conclusions: Among women at high risk for diabetes, natural menopause was not associated with diabetes risk and did not affect response to diabetes prevention interventions. In the lifestyle intervention, bilateral oophorectomy was associated with a decreased diabetes risk.",
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