Menopausal hot flashes and the default mode network

Rebecca C. Thurston, Pauline M. Maki, Carol A. Derby, Ervin Sejdić, Howard J. Aizenstein

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective To test whether more physiologically assessed hot flashes were associated with more connectivity in the default mode network (DMN), the network of brain regions active during rest. We particularly focus on DMN networks supporting the hippocampus as this region is rich in estrogen (E) receptors (ER) and has previously been linked to hot flashes. Design Women underwent 24 hours of physiologic and diary hot flash monitoring, functional magnetic resonance imaging (MRI), 72 hours of sleep actigraphy monitoring, a blood draw, questionnaires, and physical measures. Setting University medical center. Patient(s) Twenty midlife women aged 40-60 years who had their uterus and both ovaries and were not taking hormone therapy (HT). Intervention(s) None. Main Outcome Measure(s) The DMN functional connectivity. Result(s) Controlling for age, race, and education, more physiologically-monitored hot flashes were associated with greater DMN connectivity (beta, B [SE] = 0.004 [0.002]), particularly hippocampal DMN connectivity (B [SE] = 0.005 [0.002]). Findings were most pronounced for sleep physiologic hot flashes (with hippocampal DMN, B [SE] = 0.02 [0.007]). Associations also persisted controlling for sleep, depressive symptoms, and serum E<inf>2</inf> concentrations. Conclusion(s) More physiologically-monitored hot flashes were associated with more DMN connectivity, particularly networks supporting the hippocampus. Findings were most pronounced for sleep hot flashes. Findings underscore the importance of continued investigation of the central nervous system in efforts to understand this classic menopausal phenomenon.

Original languageEnglish (US)
Pages (from-to)1572-1578.e1
JournalFertility and Sterility
Volume103
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Hot Flashes
Sleep
Hippocampus
Actigraphy
Polysomnography
Estrogen Receptors
Uterus
Ovary
Central Nervous System
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Hormones
Depression
Education
Brain
Serum

Keywords

  • brain
  • default mode network
  • hippocampus
  • Hot flashes
  • vasomotor symptoms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Thurston, R. C., Maki, P. M., Derby, C. A., Sejdić, E., & Aizenstein, H. J. (2015). Menopausal hot flashes and the default mode network. Fertility and Sterility, 103(6), 1572-1578.e1. https://doi.org/10.1016/j.fertnstert.2015.03.008

Menopausal hot flashes and the default mode network. / Thurston, Rebecca C.; Maki, Pauline M.; Derby, Carol A.; Sejdić, Ervin; Aizenstein, Howard J.

In: Fertility and Sterility, Vol. 103, No. 6, 01.06.2015, p. 1572-1578.e1.

Research output: Contribution to journalArticle

Thurston, RC, Maki, PM, Derby, CA, Sejdić, E & Aizenstein, HJ 2015, 'Menopausal hot flashes and the default mode network', Fertility and Sterility, vol. 103, no. 6, pp. 1572-1578.e1. https://doi.org/10.1016/j.fertnstert.2015.03.008
Thurston, Rebecca C. ; Maki, Pauline M. ; Derby, Carol A. ; Sejdić, Ervin ; Aizenstein, Howard J. / Menopausal hot flashes and the default mode network. In: Fertility and Sterility. 2015 ; Vol. 103, No. 6. pp. 1572-1578.e1.
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