Menarche, menopause, and breast cancer risk: Individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

N. Hamajima, K. Hirose, K. Tajima, Thomas E. Rohan, C. M. Friedenreich, E. E. Calle, S. M. Gapstur, A. V. Patel, R. J. Coates, J. M. Liff, R. Talamini, N. Chantarakul, S. Koetsawang, D. Rachawat, Y. Marcou, E. Kakouri, S. W. Duffy, A. Morabia, L. Schuman, W. StewartM. Szklo, P. F. Coogan, J. R. Palmer, L. Rosenberg, P. Band, A. J. Coldman, R. P. Gallagher, T. G. Hislop, P. Yang, S. R. Cummings, K. Canfell, F. Sitas, P. Chao, J. Lissowska, P. L. Horn-Ross, E. M. John, L. M. Kolonel, A. M Y Nomura, R. Ghiasvand, J. Hu, K. C. Johnson, Y. Mao, V. Beral, D. Bull, K. Callaghan, B. Crossley, A. Goodill, J. Green, C. Hermon, T. Key, I. Lindgard, B. Liu, K. Pirie, G. Reeves, R. Collins, R. Doll, R. Peto, T. Bishop, I. S. Fentiman, S. De Sanjosé, C. A. Gonzalez, N. Lee, P. Marchbanks, H. W. Ory, H. B. Peterson, P. Wingo, K. Ebeling, D. Kunde, P. Nishan, J. L. Hopper, H. Eliassen, S. Hankinson, V. Gajalakshmi, N. Martin, T. Pardthaisong, S. Silpisornkosol, C. Theetranont, B. Boosiri, S. Chutivongse, P. Jimakorn, P. Virutamasen, C. Wongsrichanalai, A. Neugut, R. Santella, C. J. Baines, N. Kreiger, A. B. Miller, C. Wall, A. Tjonneland, T. Jorgensen, C. Stahlberg, A. Tønnes Pedersen, D. Flesch-Janys, N. Hakansson, J. Cauley, I. Heuch, H. O. Adami, I. Persson, E. Weiderpass, C. Magnusson, J. Chang-Claude, R. Kaaks, M. McCredie, C. Paul, D. C G Skegg, G. F S Spears, M. Iwasaki, S. Tsugane, G. Anderson, J. R. Daling, J. Hampton, W. B. Hutchinson, C. I. Li, K. Malone, M. Mandelson, P. Newcomb, E. A. Noonan, R. M. Ray, J. L. Stanford, M. T C Tang, D. B. Thomas, N. S. Weiss, E. White, A. Izquierdo, P. Viladiu, E. O. Fourkala, I. Jacobs, U. Menon, A. Ryan, H. R. Cuevas, P. Ontiveros, A. Palet, S. B. Salazar, N. Aristizabal, A. Cuadros, L. Tryggvadottir, H. Tulinius, E. Riboli, N. Andrieu, A. Bachelot, M. G. Lê, A. Brêmond, B. Gairard, J. Lansac, L. Piana, R. Renaud, F. Clavel-Chapelon, A. Fournier, M. Touillaud, S. Mesrine, N. Chabbert-Buffet, M. C. Boutron-Ruault, A. Wolk, G. Torres-Mejia, S. Franceschi, I. Romieu, P. Boyle, F. Lubin, B. Modan, E. Ron, Y. Wax, G. D. Friedman, R. A. Hiatt, F. Levi, K. Kosmelj, M. Primic-Zakelj, B. Ravnihar, J. Stare, A. Ekbom, G. Erlandsson, I. Persson, W. L. Beeson, G. Fraser, J. Peto, R. L. Hanson, M. C. Leske, M. C. Mahoney, P. C. Nasca, A. O. Varma, A. L. Weinstein, M. L. Hartman, H. Olsson, R. A. Goldbohm, P. A. van den Brandt, D. Palli, S. Teitelbaum, R. A. Apelo, J. Baens, J. R. de la Cruz, B. Javier, L. B. Lacaya, C. A. Ngelangel, C. La Vecchia, E. Negri, E. Marubini, M. Ferraroni, M. C. Pike, M. Gerber, S. Richardson, C. Segala, D. Gatei, P. Kenya, A. Kungu, J. G. Mati, L. A. Brinton, M. Freedman, R. Hoover, C. Schairer, R. Ziegler, E. Banks, R. Spirtas, H. P. Lee, M. A. Rookus, F. E. van Leeuwen, J. A. Schoenberg, S. Graff-Iversen, R. Selmer, L. Jones, K. McPherson, A. Neil, M. Vessey, D. Yeates, K. Mabuchi, D. Preston, P. Hannaford, C. Kay, S. E. McCann, L. Rosero-Bixby, Y. T. Gao, F. Jin, J. M. Yuan, H. Y. Wei, T. Yun, C. Zhiheng, G. Berry, J. C. Booth, T. Jelihovsky, R. MacLennan, R. Shearman, A. Hadjisavvas, K. Kyriacou, M. Loisidou, X. Zhou, Q. S. Wang, M. Kawai, Y. Minami, I. Tsuji, E. Lund, M. Kumle, H. Stalsberg, X. O. Shu, W. Zheng, E. M. Monninkhof, N. C. Onland-Moret, P. H M Peeters, K. Katsouyanni, A. Trichopoulou, D. Trichopoulos, A. Tzonou, K. A. Baltzell, A. Dabancens, L. Martinez, R. Molina, O. Salas, F. E. Alexander, K. Anderson, A. R. Folsom, M. D. Gammon, B. S. Hulka, R. Millikan, C. E D Chilvers, F. Lumachi, C. Bain, F. Schofield, V. Siskind, T. R. Rebbeck, L. R. Bernstein, S. Enger, R. W. Haile, A. Paganini-Hill, R. K. Ross, G. Ursin, A. H. Wu, M. C. Yu, M. Ewertz, E. A. Clarke, L. Bergkvist, G. L. Anderson, M. Gass, M. J. O'Sullivan, A. Kalache, T. M M Farley, S. Holck, O. Meirik, A. Fukao

Research output: Contribution to journalArticle

326 Citations (Scopus)

Abstract

Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression. Findings Breast cancer risk increased by a factor of 1.050 (95% CI 1.044-1.057; p<0.0001) for every year younger at menarche, and independently by a smaller amount (1.029, 1.025-1.032; p<0.0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45-54 years 1.43, 1.33-1.52, p<0.001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p<0.006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p<0.01 for both comparisons). Interpretation The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptorpositive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours.

Original languageEnglish (US)
Pages (from-to)1141-1151
Number of pages11
JournalThe Lancet Oncology
Volume13
Issue number11
DOIs
StatePublished - Nov 2012

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Menarche
Menopause
Meta-Analysis
Epidemiologic Studies
Breast Neoplasms
Estrogen Receptors
Neoplasms
Hormones
Adiposity
Contraceptive Agents
Alcohol Drinking
Reproduction
Histology
Estrogens
Smoking
History
Parturition

ASJC Scopus subject areas

  • Oncology

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Menarche, menopause, and breast cancer risk : Individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. / Hamajima, N.; Hirose, K.; Tajima, K.; Rohan, Thomas E.; Friedenreich, C. M.; Calle, E. E.; Gapstur, S. M.; Patel, A. V.; Coates, R. J.; Liff, J. M.; Talamini, R.; Chantarakul, N.; Koetsawang, S.; Rachawat, D.; Marcou, Y.; Kakouri, E.; Duffy, S. W.; Morabia, A.; Schuman, L.; Stewart, W.; Szklo, M.; Coogan, P. F.; Palmer, J. R.; Rosenberg, L.; Band, P.; Coldman, A. J.; Gallagher, R. P.; Hislop, T. G.; Yang, P.; Cummings, S. R.; Canfell, K.; Sitas, F.; Chao, P.; Lissowska, J.; Horn-Ross, P. L.; John, E. M.; Kolonel, L. M.; Nomura, A. M Y; Ghiasvand, R.; Hu, J.; Johnson, K. C.; Mao, Y.; Beral, V.; Bull, D.; Callaghan, K.; Crossley, B.; Goodill, A.; Green, J.; Hermon, C.; Key, T.; Lindgard, I.; Liu, B.; Pirie, K.; Reeves, G.; Collins, R.; Doll, R.; Peto, R.; Bishop, T.; Fentiman, I. S.; De Sanjosé, S.; Gonzalez, C. A.; Lee, N.; Marchbanks, P.; Ory, H. W.; Peterson, H. B.; Wingo, P.; Ebeling, K.; Kunde, D.; Nishan, P.; Hopper, J. L.; Eliassen, H.; Hankinson, S.; Gajalakshmi, V.; Martin, N.; Pardthaisong, T.; Silpisornkosol, S.; Theetranont, C.; Boosiri, B.; Chutivongse, S.; Jimakorn, P.; Virutamasen, P.; Wongsrichanalai, C.; Neugut, A.; Santella, R.; Baines, C. J.; Kreiger, N.; Miller, A. B.; Wall, C.; Tjonneland, A.; Jorgensen, T.; Stahlberg, C.; Pedersen, A. Tønnes; Flesch-Janys, D.; Hakansson, N.; Cauley, J.; Heuch, I.; Adami, H. O.; Persson, I.; Weiderpass, E.; Magnusson, C.; Chang-Claude, J.; Kaaks, R.; McCredie, M.; Paul, C.; Skegg, D. C G; Spears, G. F S; Iwasaki, M.; Tsugane, S.; Anderson, G.; Daling, J. R.; Hampton, J.; Hutchinson, W. B.; Li, C. I.; Malone, K.; Mandelson, M.; Newcomb, P.; Noonan, E. A.; Ray, R. M.; Stanford, J. L.; Tang, M. T C; Thomas, D. B.; Weiss, N. S.; White, E.; Izquierdo, A.; Viladiu, P.; Fourkala, E. O.; Jacobs, I.; Menon, U.; Ryan, A.; Cuevas, H. R.; Ontiveros, P.; Palet, A.; Salazar, S. B.; Aristizabal, N.; Cuadros, A.; Tryggvadottir, L.; Tulinius, H.; Riboli, E.; Andrieu, N.; Bachelot, A.; Lê, M. G.; Brêmond, A.; Gairard, B.; Lansac, J.; Piana, L.; Renaud, R.; Clavel-Chapelon, F.; Fournier, A.; Touillaud, M.; Mesrine, S.; Chabbert-Buffet, N.; Boutron-Ruault, M. C.; Wolk, A.; Torres-Mejia, G.; Franceschi, S.; Romieu, I.; Boyle, P.; Lubin, F.; Modan, B.; Ron, E.; Wax, Y.; Friedman, G. D.; Hiatt, R. A.; Levi, F.; Kosmelj, K.; Primic-Zakelj, M.; Ravnihar, B.; Stare, J.; Ekbom, A.; Erlandsson, G.; Persson, I.; Beeson, W. L.; Fraser, G.; Peto, J.; Hanson, R. L.; Leske, M. C.; Mahoney, M. C.; Nasca, P. C.; Varma, A. O.; Weinstein, A. L.; Hartman, M. L.; Olsson, H.; Goldbohm, R. A.; van den Brandt, P. A.; Palli, D.; Teitelbaum, S.; Apelo, R. A.; Baens, J.; de la Cruz, J. R.; Javier, B.; Lacaya, L. B.; Ngelangel, C. A.; La Vecchia, C.; Negri, E.; Marubini, E.; Ferraroni, M.; Pike, M. C.; Gerber, M.; Richardson, S.; Segala, C.; Gatei, D.; Kenya, P.; Kungu, A.; Mati, J. G.; Brinton, L. A.; Freedman, M.; Hoover, R.; Schairer, C.; Ziegler, R.; Banks, E.; Spirtas, R.; Lee, H. P.; Rookus, M. A.; van Leeuwen, F. E.; Schoenberg, J. A.; Graff-Iversen, S.; Selmer, R.; Jones, L.; McPherson, K.; Neil, A.; Vessey, M.; Yeates, D.; Mabuchi, K.; Preston, D.; Hannaford, P.; Kay, C.; McCann, S. E.; Rosero-Bixby, L.; Gao, Y. T.; Jin, F.; Yuan, J. M.; Wei, H. Y.; Yun, T.; Zhiheng, C.; Berry, G.; Booth, J. C.; Jelihovsky, T.; MacLennan, R.; Shearman, R.; Hadjisavvas, A.; Kyriacou, K.; Loisidou, M.; Zhou, X.; Wang, Q. S.; Kawai, M.; Minami, Y.; Tsuji, I.; Lund, E.; Kumle, M.; Stalsberg, H.; Shu, X. O.; Zheng, W.; Monninkhof, E. M.; Onland-Moret, N. C.; Peeters, P. H M; Katsouyanni, K.; Trichopoulou, A.; Trichopoulos, D.; Tzonou, A.; Baltzell, K. A.; Dabancens, A.; Martinez, L.; Molina, R.; Salas, O.; Alexander, F. E.; Anderson, K.; Folsom, A. R.; Gammon, M. D.; Hulka, B. S.; Millikan, R.; Chilvers, C. E D; Lumachi, F.; Bain, C.; Schofield, F.; Siskind, V.; Rebbeck, T. R.; Bernstein, L. R.; Enger, S.; Haile, R. W.; Paganini-Hill, A.; Ross, R. K.; Ursin, G.; Wu, A. H.; Yu, M. C.; Ewertz, M.; Clarke, E. A.; Bergkvist, L.; Anderson, G. L.; Gass, M.; O'Sullivan, M. J.; Kalache, A.; Farley, T. M M; Holck, S.; Meirik, O.; Fukao, A.

In: The Lancet Oncology, Vol. 13, No. 11, 11.2012, p. 1141-1151.

Research output: Contribution to journalArticle

Hamajima, N, Hirose, K, Tajima, K, Rohan, TE, Friedenreich, CM, Calle, EE, Gapstur, SM, Patel, AV, Coates, RJ, Liff, JM, Talamini, R, Chantarakul, N, Koetsawang, S, Rachawat, D, Marcou, Y, Kakouri, E, Duffy, SW, Morabia, A, Schuman, L, Stewart, W, Szklo, M, Coogan, PF, Palmer, JR, Rosenberg, L, Band, P, Coldman, AJ, Gallagher, RP, Hislop, TG, Yang, P, Cummings, SR, Canfell, K, Sitas, F, Chao, P, Lissowska, J, Horn-Ross, PL, John, EM, Kolonel, LM, Nomura, AMY, Ghiasvand, R, Hu, J, Johnson, KC, Mao, Y, Beral, V, Bull, D, Callaghan, K, Crossley, B, Goodill, A, Green, J, Hermon, C, Key, T, Lindgard, I, Liu, B, Pirie, K, Reeves, G, Collins, R, Doll, R, Peto, R, Bishop, T, Fentiman, IS, De Sanjosé, S, Gonzalez, CA, Lee, N, Marchbanks, P, Ory, HW, Peterson, HB, Wingo, P, Ebeling, K, Kunde, D, Nishan, P, Hopper, JL, Eliassen, H, Hankinson, S, Gajalakshmi, V, Martin, N, Pardthaisong, T, Silpisornkosol, S, Theetranont, C, Boosiri, B, Chutivongse, S, Jimakorn, P, Virutamasen, P, Wongsrichanalai, C, Neugut, A, Santella, R, Baines, CJ, Kreiger, N, Miller, AB, Wall, C, Tjonneland, A, Jorgensen, T, Stahlberg, C, Pedersen, AT, Flesch-Janys, D, Hakansson, N, Cauley, J, Heuch, I, Adami, HO, Persson, I, Weiderpass, E, Magnusson, C, Chang-Claude, J, Kaaks, R, McCredie, M, Paul, C, Skegg, DCG, Spears, GFS, Iwasaki, M, Tsugane, S, Anderson, G, Daling, JR, Hampton, J, Hutchinson, WB, Li, CI, Malone, K, Mandelson, M, Newcomb, P, Noonan, EA, Ray, RM, Stanford, JL, Tang, MTC, Thomas, DB, Weiss, NS, White, E, Izquierdo, A, Viladiu, P, Fourkala, EO, Jacobs, I, Menon, U, Ryan, A, Cuevas, HR, Ontiveros, P, Palet, A, Salazar, SB, Aristizabal, N, Cuadros, A, Tryggvadottir, L, Tulinius, H, Riboli, E, Andrieu, N, Bachelot, A, Lê, MG, Brêmond, A, Gairard, B, Lansac, J, Piana, L, Renaud, R, Clavel-Chapelon, F, Fournier, A, Touillaud, M, Mesrine, S, Chabbert-Buffet, N, Boutron-Ruault, MC, Wolk, A, Torres-Mejia, G, Franceschi, S, Romieu, I, Boyle, P, Lubin, F, Modan, B, Ron, E, Wax, Y, Friedman, GD, Hiatt, RA, Levi, F, Kosmelj, K, Primic-Zakelj, M, Ravnihar, B, Stare, J, Ekbom, A, Erlandsson, G, Persson, I, Beeson, WL, Fraser, G, Peto, J, Hanson, RL, Leske, MC, Mahoney, MC, Nasca, PC, Varma, AO, Weinstein, AL, Hartman, ML, Olsson, H, Goldbohm, RA, van den Brandt, PA, Palli, D, Teitelbaum, S, Apelo, RA, Baens, J, de la Cruz, JR, Javier, B, Lacaya, LB, Ngelangel, CA, La Vecchia, C, Negri, E, Marubini, E, Ferraroni, M, Pike, MC, Gerber, M, Richardson, S, Segala, C, Gatei, D, Kenya, P, Kungu, A, Mati, JG, Brinton, LA, Freedman, M, Hoover, R, Schairer, C, Ziegler, R, Banks, E, Spirtas, R, Lee, HP, Rookus, MA, van Leeuwen, FE, Schoenberg, JA, Graff-Iversen, S, Selmer, R, Jones, L, McPherson, K, Neil, A, Vessey, M, Yeates, D, Mabuchi, K, Preston, D, Hannaford, P, Kay, C, McCann, SE, Rosero-Bixby, L, Gao, YT, Jin, F, Yuan, JM, Wei, HY, Yun, T, Zhiheng, C, Berry, G, Booth, JC, Jelihovsky, T, MacLennan, R, Shearman, R, Hadjisavvas, A, Kyriacou, K, Loisidou, M, Zhou, X, Wang, QS, Kawai, M, Minami, Y, Tsuji, I, Lund, E, Kumle, M, Stalsberg, H, Shu, XO, Zheng, W, Monninkhof, EM, Onland-Moret, NC, Peeters, PHM, Katsouyanni, K, Trichopoulou, A, Trichopoulos, D, Tzonou, A, Baltzell, KA, Dabancens, A, Martinez, L, Molina, R, Salas, O, Alexander, FE, Anderson, K, Folsom, AR, Gammon, MD, Hulka, BS, Millikan, R, Chilvers, CED, Lumachi, F, Bain, C, Schofield, F, Siskind, V, Rebbeck, TR, Bernstein, LR, Enger, S, Haile, RW, Paganini-Hill, A, Ross, RK, Ursin, G, Wu, AH, Yu, MC, Ewertz, M, Clarke, EA, Bergkvist, L, Anderson, GL, Gass, M, O'Sullivan, MJ, Kalache, A, Farley, TMM, Holck, S, Meirik, O & Fukao, A 2012, 'Menarche, menopause, and breast cancer risk: Individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies', The Lancet Oncology, vol. 13, no. 11, pp. 1141-1151. https://doi.org/10.1016/S1470-2045(12)70425-4
Hamajima, N. ; Hirose, K. ; Tajima, K. ; Rohan, Thomas E. ; Friedenreich, C. M. ; Calle, E. E. ; Gapstur, S. M. ; Patel, A. V. ; Coates, R. J. ; Liff, J. M. ; Talamini, R. ; Chantarakul, N. ; Koetsawang, S. ; Rachawat, D. ; Marcou, Y. ; Kakouri, E. ; Duffy, S. W. ; Morabia, A. ; Schuman, L. ; Stewart, W. ; Szklo, M. ; Coogan, P. F. ; Palmer, J. R. ; Rosenberg, L. ; Band, P. ; Coldman, A. J. ; Gallagher, R. P. ; Hislop, T. G. ; Yang, P. ; Cummings, S. R. ; Canfell, K. ; Sitas, F. ; Chao, P. ; Lissowska, J. ; Horn-Ross, P. L. ; John, E. M. ; Kolonel, L. M. ; Nomura, A. M Y ; Ghiasvand, R. ; Hu, J. ; Johnson, K. C. ; Mao, Y. ; Beral, V. ; Bull, D. ; Callaghan, K. ; Crossley, B. ; Goodill, A. ; Green, J. ; Hermon, C. ; Key, T. ; Lindgard, I. ; Liu, B. ; Pirie, K. ; Reeves, G. ; Collins, R. ; Doll, R. ; Peto, R. ; Bishop, T. ; Fentiman, I. S. ; De Sanjosé, S. ; Gonzalez, C. A. ; Lee, N. ; Marchbanks, P. ; Ory, H. W. ; Peterson, H. B. ; Wingo, P. ; Ebeling, K. ; Kunde, D. ; Nishan, P. ; Hopper, J. L. ; Eliassen, H. ; Hankinson, S. ; Gajalakshmi, V. ; Martin, N. ; Pardthaisong, T. ; Silpisornkosol, S. ; Theetranont, C. ; Boosiri, B. ; Chutivongse, S. ; Jimakorn, P. ; Virutamasen, P. ; Wongsrichanalai, C. ; Neugut, A. ; Santella, R. ; Baines, C. J. ; Kreiger, N. ; Miller, A. B. ; Wall, C. ; Tjonneland, A. ; Jorgensen, T. ; Stahlberg, C. ; Pedersen, A. Tønnes ; Flesch-Janys, D. ; Hakansson, N. ; Cauley, J. ; Heuch, I. ; Adami, H. O. ; Persson, I. ; Weiderpass, E. ; Magnusson, C. ; Chang-Claude, J. ; Kaaks, R. ; McCredie, M. ; Paul, C. ; Skegg, D. C G ; Spears, G. F S ; Iwasaki, M. ; Tsugane, S. ; Anderson, G. ; Daling, J. R. ; Hampton, J. ; Hutchinson, W. B. ; Li, C. I. ; Malone, K. ; Mandelson, M. ; Newcomb, P. ; Noonan, E. A. ; Ray, R. M. ; Stanford, J. L. ; Tang, M. T C ; Thomas, D. B. ; Weiss, N. S. ; White, E. ; Izquierdo, A. ; Viladiu, P. ; Fourkala, E. O. ; Jacobs, I. ; Menon, U. ; Ryan, A. ; Cuevas, H. R. ; Ontiveros, P. ; Palet, A. ; Salazar, S. B. ; Aristizabal, N. ; Cuadros, A. ; Tryggvadottir, L. ; Tulinius, H. ; Riboli, E. ; Andrieu, N. ; Bachelot, A. ; Lê, M. G. ; Brêmond, A. ; Gairard, B. ; Lansac, J. ; Piana, L. ; Renaud, R. ; Clavel-Chapelon, F. ; Fournier, A. ; Touillaud, M. ; Mesrine, S. ; Chabbert-Buffet, N. ; Boutron-Ruault, M. C. ; Wolk, A. ; Torres-Mejia, G. ; Franceschi, S. ; Romieu, I. ; Boyle, P. ; Lubin, F. ; Modan, B. ; Ron, E. ; Wax, Y. ; Friedman, G. D. ; Hiatt, R. A. ; Levi, F. ; Kosmelj, K. ; Primic-Zakelj, M. ; Ravnihar, B. ; Stare, J. ; Ekbom, A. ; Erlandsson, G. ; Persson, I. ; Beeson, W. L. ; Fraser, G. ; Peto, J. ; Hanson, R. L. ; Leske, M. C. ; Mahoney, M. C. ; Nasca, P. C. ; Varma, A. O. ; Weinstein, A. L. ; Hartman, M. L. ; Olsson, H. ; Goldbohm, R. A. ; van den Brandt, P. A. ; Palli, D. ; Teitelbaum, S. ; Apelo, R. A. ; Baens, J. ; de la Cruz, J. R. ; Javier, B. ; Lacaya, L. B. ; Ngelangel, C. A. ; La Vecchia, C. ; Negri, E. ; Marubini, E. ; Ferraroni, M. ; Pike, M. C. ; Gerber, M. ; Richardson, S. ; Segala, C. ; Gatei, D. ; Kenya, P. ; Kungu, A. ; Mati, J. G. ; Brinton, L. A. ; Freedman, M. ; Hoover, R. ; Schairer, C. ; Ziegler, R. ; Banks, E. ; Spirtas, R. ; Lee, H. P. ; Rookus, M. A. ; van Leeuwen, F. E. ; Schoenberg, J. A. ; Graff-Iversen, S. ; Selmer, R. ; Jones, L. ; McPherson, K. ; Neil, A. ; Vessey, M. ; Yeates, D. ; Mabuchi, K. ; Preston, D. ; Hannaford, P. ; Kay, C. ; McCann, S. E. ; Rosero-Bixby, L. ; Gao, Y. T. ; Jin, F. ; Yuan, J. M. ; Wei, H. Y. ; Yun, T. ; Zhiheng, C. ; Berry, G. ; Booth, J. C. ; Jelihovsky, T. ; MacLennan, R. ; Shearman, R. ; Hadjisavvas, A. ; Kyriacou, K. ; Loisidou, M. ; Zhou, X. ; Wang, Q. S. ; Kawai, M. ; Minami, Y. ; Tsuji, I. ; Lund, E. ; Kumle, M. ; Stalsberg, H. ; Shu, X. O. ; Zheng, W. ; Monninkhof, E. M. ; Onland-Moret, N. C. ; Peeters, P. H M ; Katsouyanni, K. ; Trichopoulou, A. ; Trichopoulos, D. ; Tzonou, A. ; Baltzell, K. A. ; Dabancens, A. ; Martinez, L. ; Molina, R. ; Salas, O. ; Alexander, F. E. ; Anderson, K. ; Folsom, A. R. ; Gammon, M. D. ; Hulka, B. S. ; Millikan, R. ; Chilvers, C. E D ; Lumachi, F. ; Bain, C. ; Schofield, F. ; Siskind, V. ; Rebbeck, T. R. ; Bernstein, L. R. ; Enger, S. ; Haile, R. W. ; Paganini-Hill, A. ; Ross, R. K. ; Ursin, G. ; Wu, A. H. ; Yu, M. C. ; Ewertz, M. ; Clarke, E. A. ; Bergkvist, L. ; Anderson, G. L. ; Gass, M. ; O'Sullivan, M. J. ; Kalache, A. ; Farley, T. M M ; Holck, S. ; Meirik, O. ; Fukao, A. / Menarche, menopause, and breast cancer risk : Individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. In: The Lancet Oncology. 2012 ; Vol. 13, No. 11. pp. 1141-1151.
@article{61fd628ae24040d2a45e848f26344c29,
title = "Menarche, menopause, and breast cancer risk: Individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies",
abstract = "Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression. Findings Breast cancer risk increased by a factor of 1.050 (95{\%} CI 1.044-1.057; p<0.0001) for every year younger at menarche, and independently by a smaller amount (1.029, 1.025-1.032; p<0.0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45-54 years 1.43, 1.33-1.52, p<0.001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p<0.006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p<0.01 for both comparisons). Interpretation The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptorpositive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours.",
author = "N. Hamajima and K. Hirose and K. Tajima and Rohan, {Thomas E.} and Friedenreich, {C. M.} and Calle, {E. E.} and Gapstur, {S. M.} and Patel, {A. V.} and Coates, {R. J.} and Liff, {J. M.} and R. Talamini and N. Chantarakul and S. Koetsawang and D. Rachawat and Y. Marcou and E. Kakouri and Duffy, {S. W.} and A. Morabia and L. Schuman and W. Stewart and M. Szklo and Coogan, {P. F.} and Palmer, {J. R.} and L. Rosenberg and P. Band and Coldman, {A. J.} and Gallagher, {R. P.} and Hislop, {T. G.} and P. Yang and Cummings, {S. R.} and K. Canfell and F. Sitas and P. Chao and J. Lissowska and Horn-Ross, {P. L.} and John, {E. M.} and Kolonel, {L. M.} and Nomura, {A. M Y} and R. Ghiasvand and J. Hu and Johnson, {K. C.} and Y. Mao and V. Beral and D. Bull and K. Callaghan and B. Crossley and A. Goodill and J. Green and C. Hermon and T. Key and I. Lindgard and B. Liu and K. Pirie and G. Reeves and R. Collins and R. Doll and R. Peto and T. Bishop and Fentiman, {I. S.} and {De Sanjos{\'e}}, S. and Gonzalez, {C. A.} and N. Lee and P. Marchbanks and Ory, {H. W.} and Peterson, {H. B.} and P. Wingo and K. Ebeling and D. Kunde and P. Nishan and Hopper, {J. L.} and H. Eliassen and S. Hankinson and V. Gajalakshmi and N. Martin and T. Pardthaisong and S. Silpisornkosol and C. Theetranont and B. Boosiri and S. Chutivongse and P. Jimakorn and P. Virutamasen and C. Wongsrichanalai and A. Neugut and R. Santella and Baines, {C. J.} and N. Kreiger and Miller, {A. B.} and C. Wall and A. Tjonneland and T. Jorgensen and C. Stahlberg and Pedersen, {A. T{\o}nnes} and D. Flesch-Janys and N. Hakansson and J. Cauley and I. Heuch and Adami, {H. O.} and I. Persson and E. Weiderpass and C. Magnusson and J. Chang-Claude and R. Kaaks and M. McCredie and C. Paul and Skegg, {D. C G} and Spears, {G. F S} and M. Iwasaki and S. Tsugane and G. Anderson and Daling, {J. R.} and J. Hampton and Hutchinson, {W. B.} and Li, {C. I.} and K. Malone and M. Mandelson and P. Newcomb and Noonan, {E. A.} and Ray, {R. M.} and Stanford, {J. L.} and Tang, {M. T C} and Thomas, {D. B.} and Weiss, {N. S.} and E. White and A. Izquierdo and P. Viladiu and Fourkala, {E. O.} and I. Jacobs and U. Menon and A. Ryan and Cuevas, {H. R.} and P. Ontiveros and A. Palet and Salazar, {S. B.} and N. Aristizabal and A. Cuadros and L. Tryggvadottir and H. Tulinius and E. Riboli and N. Andrieu and A. Bachelot and L{\^e}, {M. G.} and A. Br{\^e}mond and B. Gairard and J. Lansac and L. Piana and R. Renaud and F. Clavel-Chapelon and A. Fournier and M. Touillaud and S. Mesrine and N. Chabbert-Buffet and Boutron-Ruault, {M. C.} and A. Wolk and G. Torres-Mejia and S. Franceschi and I. Romieu and P. Boyle and F. Lubin and B. Modan and E. Ron and Y. Wax and Friedman, {G. D.} and Hiatt, {R. A.} and F. Levi and K. Kosmelj and M. Primic-Zakelj and B. Ravnihar and J. Stare and A. Ekbom and G. Erlandsson and I. Persson and Beeson, {W. L.} and G. Fraser and J. Peto and Hanson, {R. L.} and Leske, {M. C.} and Mahoney, {M. C.} and Nasca, {P. C.} and Varma, {A. O.} and Weinstein, {A. L.} and Hartman, {M. L.} and H. Olsson and Goldbohm, {R. A.} and {van den Brandt}, {P. A.} and D. Palli and S. Teitelbaum and Apelo, {R. A.} and J. Baens and {de la Cruz}, {J. R.} and B. Javier and Lacaya, {L. B.} and Ngelangel, {C. A.} and {La Vecchia}, C. and E. Negri and E. Marubini and M. Ferraroni and Pike, {M. C.} and M. Gerber and S. Richardson and C. Segala and D. Gatei and P. Kenya and A. Kungu and Mati, {J. G.} and Brinton, {L. A.} and M. Freedman and R. Hoover and C. Schairer and R. Ziegler and E. Banks and R. Spirtas and Lee, {H. P.} and Rookus, {M. A.} and {van Leeuwen}, {F. E.} and Schoenberg, {J. A.} and S. Graff-Iversen and R. Selmer and L. Jones and K. McPherson and A. Neil and M. Vessey and D. Yeates and K. Mabuchi and D. Preston and P. Hannaford and C. Kay and McCann, {S. E.} and L. Rosero-Bixby and Gao, {Y. T.} and F. Jin and Yuan, {J. M.} and Wei, {H. Y.} and T. Yun and C. Zhiheng and G. Berry and Booth, {J. C.} and T. Jelihovsky and R. MacLennan and R. Shearman and A. Hadjisavvas and K. Kyriacou and M. Loisidou and X. Zhou and Wang, {Q. S.} and M. Kawai and Y. Minami and I. Tsuji and E. Lund and M. Kumle and H. Stalsberg and Shu, {X. O.} and W. Zheng and Monninkhof, {E. M.} and Onland-Moret, {N. C.} and Peeters, {P. H M} and K. Katsouyanni and A. Trichopoulou and D. Trichopoulos and A. Tzonou and Baltzell, {K. A.} and A. Dabancens and L. Martinez and R. Molina and O. Salas and Alexander, {F. E.} and K. Anderson and Folsom, {A. R.} and Gammon, {M. D.} and Hulka, {B. S.} and R. Millikan and Chilvers, {C. E D} and F. Lumachi and C. Bain and F. Schofield and V. Siskind and Rebbeck, {T. R.} and Bernstein, {L. R.} and S. Enger and Haile, {R. W.} and A. Paganini-Hill and Ross, {R. K.} and G. Ursin and Wu, {A. H.} and Yu, {M. C.} and M. Ewertz and Clarke, {E. A.} and L. Bergkvist and Anderson, {G. L.} and M. Gass and O'Sullivan, {M. J.} and A. Kalache and Farley, {T. M M} and S. Holck and O. Meirik and A. Fukao",
year = "2012",
month = "11",
doi = "10.1016/S1470-2045(12)70425-4",
language = "English (US)",
volume = "13",
pages = "1141--1151",
journal = "The Lancet Oncology",
issn = "1470-2045",
publisher = "Lancet Publishing Group",
number = "11",

}

TY - JOUR

T1 - Menarche, menopause, and breast cancer risk

T2 - Individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

AU - Hamajima, N.

AU - Hirose, K.

AU - Tajima, K.

AU - Rohan, Thomas E.

AU - Friedenreich, C. M.

AU - Calle, E. E.

AU - Gapstur, S. M.

AU - Patel, A. V.

AU - Coates, R. J.

AU - Liff, J. M.

AU - Talamini, R.

AU - Chantarakul, N.

AU - Koetsawang, S.

AU - Rachawat, D.

AU - Marcou, Y.

AU - Kakouri, E.

AU - Duffy, S. W.

AU - Morabia, A.

AU - Schuman, L.

AU - Stewart, W.

AU - Szklo, M.

AU - Coogan, P. F.

AU - Palmer, J. R.

AU - Rosenberg, L.

AU - Band, P.

AU - Coldman, A. J.

AU - Gallagher, R. P.

AU - Hislop, T. G.

AU - Yang, P.

AU - Cummings, S. R.

AU - Canfell, K.

AU - Sitas, F.

AU - Chao, P.

AU - Lissowska, J.

AU - Horn-Ross, P. L.

AU - John, E. M.

AU - Kolonel, L. M.

AU - Nomura, A. M Y

AU - Ghiasvand, R.

AU - Hu, J.

AU - Johnson, K. C.

AU - Mao, Y.

AU - Beral, V.

AU - Bull, D.

AU - Callaghan, K.

AU - Crossley, B.

AU - Goodill, A.

AU - Green, J.

AU - Hermon, C.

AU - Key, T.

AU - Lindgard, I.

AU - Liu, B.

AU - Pirie, K.

AU - Reeves, G.

AU - Collins, R.

AU - Doll, R.

AU - Peto, R.

AU - Bishop, T.

AU - Fentiman, I. S.

AU - De Sanjosé, S.

AU - Gonzalez, C. A.

AU - Lee, N.

AU - Marchbanks, P.

AU - Ory, H. W.

AU - Peterson, H. B.

AU - Wingo, P.

AU - Ebeling, K.

AU - Kunde, D.

AU - Nishan, P.

AU - Hopper, J. L.

AU - Eliassen, H.

AU - Hankinson, S.

AU - Gajalakshmi, V.

AU - Martin, N.

AU - Pardthaisong, T.

AU - Silpisornkosol, S.

AU - Theetranont, C.

AU - Boosiri, B.

AU - Chutivongse, S.

AU - Jimakorn, P.

AU - Virutamasen, P.

AU - Wongsrichanalai, C.

AU - Neugut, A.

AU - Santella, R.

AU - Baines, C. J.

AU - Kreiger, N.

AU - Miller, A. B.

AU - Wall, C.

AU - Tjonneland, A.

AU - Jorgensen, T.

AU - Stahlberg, C.

AU - Pedersen, A. Tønnes

AU - Flesch-Janys, D.

AU - Hakansson, N.

AU - Cauley, J.

AU - Heuch, I.

AU - Adami, H. O.

AU - Persson, I.

AU - Weiderpass, E.

AU - Magnusson, C.

AU - Chang-Claude, J.

AU - Kaaks, R.

AU - McCredie, M.

AU - Paul, C.

AU - Skegg, D. C G

AU - Spears, G. F S

AU - Iwasaki, M.

AU - Tsugane, S.

AU - Anderson, G.

AU - Daling, J. R.

AU - Hampton, J.

AU - Hutchinson, W. B.

AU - Li, C. I.

AU - Malone, K.

AU - Mandelson, M.

AU - Newcomb, P.

AU - Noonan, E. A.

AU - Ray, R. M.

AU - Stanford, J. L.

AU - Tang, M. T C

AU - Thomas, D. B.

AU - Weiss, N. S.

AU - White, E.

AU - Izquierdo, A.

AU - Viladiu, P.

AU - Fourkala, E. O.

AU - Jacobs, I.

AU - Menon, U.

AU - Ryan, A.

AU - Cuevas, H. R.

AU - Ontiveros, P.

AU - Palet, A.

AU - Salazar, S. B.

AU - Aristizabal, N.

AU - Cuadros, A.

AU - Tryggvadottir, L.

AU - Tulinius, H.

AU - Riboli, E.

AU - Andrieu, N.

AU - Bachelot, A.

AU - Lê, M. G.

AU - Brêmond, A.

AU - Gairard, B.

AU - Lansac, J.

AU - Piana, L.

AU - Renaud, R.

AU - Clavel-Chapelon, F.

AU - Fournier, A.

AU - Touillaud, M.

AU - Mesrine, S.

AU - Chabbert-Buffet, N.

AU - Boutron-Ruault, M. C.

AU - Wolk, A.

AU - Torres-Mejia, G.

AU - Franceschi, S.

AU - Romieu, I.

AU - Boyle, P.

AU - Lubin, F.

AU - Modan, B.

AU - Ron, E.

AU - Wax, Y.

AU - Friedman, G. D.

AU - Hiatt, R. A.

AU - Levi, F.

AU - Kosmelj, K.

AU - Primic-Zakelj, M.

AU - Ravnihar, B.

AU - Stare, J.

AU - Ekbom, A.

AU - Erlandsson, G.

AU - Persson, I.

AU - Beeson, W. L.

AU - Fraser, G.

AU - Peto, J.

AU - Hanson, R. L.

AU - Leske, M. C.

AU - Mahoney, M. C.

AU - Nasca, P. C.

AU - Varma, A. O.

AU - Weinstein, A. L.

AU - Hartman, M. L.

AU - Olsson, H.

AU - Goldbohm, R. A.

AU - van den Brandt, P. A.

AU - Palli, D.

AU - Teitelbaum, S.

AU - Apelo, R. A.

AU - Baens, J.

AU - de la Cruz, J. R.

AU - Javier, B.

AU - Lacaya, L. B.

AU - Ngelangel, C. A.

AU - La Vecchia, C.

AU - Negri, E.

AU - Marubini, E.

AU - Ferraroni, M.

AU - Pike, M. C.

AU - Gerber, M.

AU - Richardson, S.

AU - Segala, C.

AU - Gatei, D.

AU - Kenya, P.

AU - Kungu, A.

AU - Mati, J. G.

AU - Brinton, L. A.

AU - Freedman, M.

AU - Hoover, R.

AU - Schairer, C.

AU - Ziegler, R.

AU - Banks, E.

AU - Spirtas, R.

AU - Lee, H. P.

AU - Rookus, M. A.

AU - van Leeuwen, F. E.

AU - Schoenberg, J. A.

AU - Graff-Iversen, S.

AU - Selmer, R.

AU - Jones, L.

AU - McPherson, K.

AU - Neil, A.

AU - Vessey, M.

AU - Yeates, D.

AU - Mabuchi, K.

AU - Preston, D.

AU - Hannaford, P.

AU - Kay, C.

AU - McCann, S. E.

AU - Rosero-Bixby, L.

AU - Gao, Y. T.

AU - Jin, F.

AU - Yuan, J. M.

AU - Wei, H. Y.

AU - Yun, T.

AU - Zhiheng, C.

AU - Berry, G.

AU - Booth, J. C.

AU - Jelihovsky, T.

AU - MacLennan, R.

AU - Shearman, R.

AU - Hadjisavvas, A.

AU - Kyriacou, K.

AU - Loisidou, M.

AU - Zhou, X.

AU - Wang, Q. S.

AU - Kawai, M.

AU - Minami, Y.

AU - Tsuji, I.

AU - Lund, E.

AU - Kumle, M.

AU - Stalsberg, H.

AU - Shu, X. O.

AU - Zheng, W.

AU - Monninkhof, E. M.

AU - Onland-Moret, N. C.

AU - Peeters, P. H M

AU - Katsouyanni, K.

AU - Trichopoulou, A.

AU - Trichopoulos, D.

AU - Tzonou, A.

AU - Baltzell, K. A.

AU - Dabancens, A.

AU - Martinez, L.

AU - Molina, R.

AU - Salas, O.

AU - Alexander, F. E.

AU - Anderson, K.

AU - Folsom, A. R.

AU - Gammon, M. D.

AU - Hulka, B. S.

AU - Millikan, R.

AU - Chilvers, C. E D

AU - Lumachi, F.

AU - Bain, C.

AU - Schofield, F.

AU - Siskind, V.

AU - Rebbeck, T. R.

AU - Bernstein, L. R.

AU - Enger, S.

AU - Haile, R. W.

AU - Paganini-Hill, A.

AU - Ross, R. K.

AU - Ursin, G.

AU - Wu, A. H.

AU - Yu, M. C.

AU - Ewertz, M.

AU - Clarke, E. A.

AU - Bergkvist, L.

AU - Anderson, G. L.

AU - Gass, M.

AU - O'Sullivan, M. J.

AU - Kalache, A.

AU - Farley, T. M M

AU - Holck, S.

AU - Meirik, O.

AU - Fukao, A.

PY - 2012/11

Y1 - 2012/11

N2 - Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression. Findings Breast cancer risk increased by a factor of 1.050 (95% CI 1.044-1.057; p<0.0001) for every year younger at menarche, and independently by a smaller amount (1.029, 1.025-1.032; p<0.0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45-54 years 1.43, 1.33-1.52, p<0.001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p<0.006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p<0.01 for both comparisons). Interpretation The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptorpositive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours.

AB - Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression. Findings Breast cancer risk increased by a factor of 1.050 (95% CI 1.044-1.057; p<0.0001) for every year younger at menarche, and independently by a smaller amount (1.029, 1.025-1.032; p<0.0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45-54 years 1.43, 1.33-1.52, p<0.001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p<0.006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p<0.01 for both comparisons). Interpretation The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptorpositive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours.

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U2 - 10.1016/S1470-2045(12)70425-4

DO - 10.1016/S1470-2045(12)70425-4

M3 - Article

AN - SCOPUS:84877875905

VL - 13

SP - 1141

EP - 1151

JO - The Lancet Oncology

JF - The Lancet Oncology

SN - 1470-2045

IS - 11

ER -