Memory-T-Cell-Derived Interferon-γ Instructs Potent Innate Cell Activation for Protective Immunity

Saïdi M.Homa Soudja, Ceena Chandrabos, Ernest Yakob, Mike Veenstra, Deborah Palliser, Grégoire Lauvau

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Cells of the innate immune system are essential for host defenses against primary microbial pathogen infections, yet their involvement in effective memory responses of vaccinated individuals has been poorly investigated. Here we show that memory Tcells instruct innate cells to become potent effector cells in a systemic and a mucosal model of infection. Memory Tcells controlled phagocyte, dendritic cell, and NK or NK Tcell mobilization and induction of a strong program of differentiation, which included their expression of effector cytokines and microbicidal pathways, all of which were delayed in nonvaccinated hosts. Disruption of IFN-γ signaling in Ly6C+ monocytes, dendritic cells, and macrophages impaired these processes and the control of pathogen growth. These results reveal how memory Tcells, through rapid secretion of IFN-γ, orchestrate extensive modifications of host innate immune responses that are essential for effective protection of vaccinated hosts.

Original languageEnglish (US)
Pages (from-to)974-988
Number of pages15
JournalImmunity
Volume40
Issue number6
DOIs
StatePublished - Jun 19 2014

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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