Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Julie M. Johnson-Nauroth, Jerome Graber, Karen Yao, Steve Jacobson, Peter A. Calabresi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA-/CCR7- TEM and CD45RA+/CCR7- TDiff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Rα, failed to respond to IL-7 and IL-15, and did not develop a TCM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of TEM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.

Original languageEnglish (US)
Pages (from-to)115-124
Number of pages10
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Human T-lymphotropic virus 1
T-Lymphocytes
Interleukin-15
Interleukin-7
Viral Antigens
Virus Diseases
Spinal Cord
Pathology
Phenotype
Population

Keywords

  • Cytotoxic T cells
  • Memory
  • Viral infection

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Johnson-Nauroth, J. M., Graber, J., Yao, K., Jacobson, S., & Calabresi, P. A. (2006). Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells. Journal of Neuroimmunology, 176(1-2), 115-124. https://doi.org/10.1016/j.jneuroim.2006.03.013

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells. / Johnson-Nauroth, Julie M.; Graber, Jerome; Yao, Karen; Jacobson, Steve; Calabresi, Peter A.

In: Journal of Neuroimmunology, Vol. 176, No. 1-2, 07.2006, p. 115-124.

Research output: Contribution to journalArticle

Johnson-Nauroth, JM, Graber, J, Yao, K, Jacobson, S & Calabresi, PA 2006, 'Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells', Journal of Neuroimmunology, vol. 176, no. 1-2, pp. 115-124. https://doi.org/10.1016/j.jneuroim.2006.03.013
Johnson-Nauroth, Julie M. ; Graber, Jerome ; Yao, Karen ; Jacobson, Steve ; Calabresi, Peter A. / Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells. In: Journal of Neuroimmunology. 2006 ; Vol. 176, No. 1-2. pp. 115-124.
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