Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Julie M. Johnson-Nauroth, Jerome Graber, Karen Yao, Steve Jacobson, Peter A. Calabresi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA-/CCR7- TEM and CD45RA+/CCR7- TDiff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Rα, failed to respond to IL-7 and IL-15, and did not develop a TCM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of TEM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.

Original languageEnglish (US)
Pages (from-to)115-124
Number of pages10
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
Publication statusPublished - Jul 1 2006

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Keywords

  • Cytotoxic T cells
  • Memory
  • Viral infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Johnson-Nauroth, J. M., Graber, J., Yao, K., Jacobson, S., & Calabresi, P. A. (2006). Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells. Journal of Neuroimmunology, 176(1-2), 115-124. https://doi.org/10.1016/j.jneuroim.2006.03.013