Memory impairment in Parkinson's disease: The retrieval versus associative deficit hypothesis revisited and reconciled

Ondrej Bezdicek, Tommaso Ballarini, Herman Buschke, Filip Růžicka, Jan Roth, Franziska Albrecht, Evžen Růžicka, Karsten Mueller, Matthias L. Schroeter, Robert Jech

Research output: Contribution to journalArticle

Abstract

Objective: Our study explored the retrieval deficit and the associative deficit hypotheses of memory impairments in Parkinson's disease (PD). The former supports a memory deficit mediated by attention/executive dysfunctions, whereas the latter hypothesizes a hippocampal memory impairment in PD. Method: We studied 31 controls and 34 PD patients classified as PD with normal cognition (PD-NC; n = 18) and PD with mild cognitive impairment (PD-MCI; n= 16). To test the retrieval deficit hypothesis, we measured the performance in encoding, retention, and recognition in verbal and visual domains; to test the associative deficit hypothesis, we used a specific associative binding measure. Using resting-state functional-MRI, we compared the functional connectivity of different hippocampal subfields between PD patients and controls, and we related it to memory performance. Results: Consistently with the retrieval deficit hypothesis, PD-MCI, and PD-NC, were impaired in free recall encoding and retention in comparison to controls, especially in the visual domain. However, as predicted by the associative deficit hypothesis, PD-MCI and, to a lesser extent, PD-NC, showed also significant associative and binding deficits in cued recall. Notably, PD patients compared to controls did not show structural differences, although they had lower connectivity between the anterior hippocampi and the precuneus/superior parietal cortex. Worse performance in memory was associated with a more severe disruption of the hippocampal connectivity. Conclusions: The pervasive pattern of memory impairment in PD supports both hypotheses. The interplay between the hippocampus, related to associative memory deficits, and the precuneus, related to attentional control, provides a neural signature that reconciles them.

Original languageEnglish (US)
Pages (from-to)391-405
Number of pages15
JournalNeuropsychology
Volume33
Issue number3
DOIs
StatePublished - Mar 1 2019

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Parkinson Disease
Parietal Lobe
Memory Disorders
Hippocampus
Cognition
Magnetic Resonance Imaging

Keywords

  • Memory impairment
  • Mild cognitive impairment
  • Parkinson's disease
  • Resting-state functional MRI

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Memory impairment in Parkinson's disease : The retrieval versus associative deficit hypothesis revisited and reconciled. / Bezdicek, Ondrej; Ballarini, Tommaso; Buschke, Herman; Růžicka, Filip; Roth, Jan; Albrecht, Franziska; Růžicka, Evžen; Mueller, Karsten; Schroeter, Matthias L.; Jech, Robert.

In: Neuropsychology, Vol. 33, No. 3, 01.03.2019, p. 391-405.

Research output: Contribution to journalArticle

Bezdicek, O, Ballarini, T, Buschke, H, Růžicka, F, Roth, J, Albrecht, F, Růžicka, E, Mueller, K, Schroeter, ML & Jech, R 2019, 'Memory impairment in Parkinson's disease: The retrieval versus associative deficit hypothesis revisited and reconciled', Neuropsychology, vol. 33, no. 3, pp. 391-405. https://doi.org/10.1037/neu0000503
Bezdicek, Ondrej ; Ballarini, Tommaso ; Buschke, Herman ; Růžicka, Filip ; Roth, Jan ; Albrecht, Franziska ; Růžicka, Evžen ; Mueller, Karsten ; Schroeter, Matthias L. ; Jech, Robert. / Memory impairment in Parkinson's disease : The retrieval versus associative deficit hypothesis revisited and reconciled. In: Neuropsychology. 2019 ; Vol. 33, No. 3. pp. 391-405.
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